Category: 27115-50-0

Nazli, Ibrahim Hanif; Celepci, Duygu Barut; Yakali, Guel; Topkaya, Derya; Ayguen, Muhittin; Alp, Serap published an article in 2018, the title of the article was Spectroscopic, structural and density functional theory (DFT) studies of two oxazol-5-one derivatives.Category: amides-buliding-blocks And the article contains the following content:

In this study, two oxazol-5-one derivatives, C20H20N2O2 (1) and C21H22N2O2 (2), were synthesized by getting condensed p-N,N-diethylaminobenzaldehyde with two presented hippuric acid derivatives and in further studies they were analyzed spectrochem. Mol. and crystal structures of the compounds were determined by single-crystal X-ray diffraction and the results revealed that the mol. packing of the crystal structures were stabilized by weak intraand intermol. interactions also with C-O···π, C-H···π and π···π stacking interactions. Computational studies were also performed using DFT method at B3LYP/6-311G(d,p) level of theory. Vibrational modes and chem. shifts were calculated and compared with the exptl. data. In addition, frontier MOs and mol. electrostatic potential surfaces were simulated. The calculated results show that the optimized geometries can well reproduce the crystal structure. Purpose of this study was to survey the effects of the reactants, which were condensed with each other to produce oxazol-5-one, upon the characteristic properties and crystal forms of the final oxazol-5-one. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to oxazolone condensation reaction hydrogen bond crystal structure, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Category: amides-buliding-blocks

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Krais, Annette M.; Essig, Julie Y.; Gren, Louise; Vogs, Carolina; Assarsson, Eva; Dierschke, Katrin; Nielsen, Joern; Strandberg, Bo; Pagels, Joakim; Broberg, Karin; Lindh, Christian H.; Gudmundsson, Anders; Wierzbicka, Aneta published an article in 2021, the title of the article was Biomarkers after controlled inhalation exposure to exhaust from Hydrogenated vegetable oil (HVO).Recommanded Product: 27115-50-0 And the article contains the following content:

Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicol. properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatog. tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM1 ~1μg/m3 and ~90μg/m3 for vehicles with and without exhaust aftertreatment systems, resp.) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM1 ~300μg/m3) increased urinary 4-MHA, a biomarker for p-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, p < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 27115-50-0

The Article related to hydrogenated vegetable oil inhalation exposure biomarker, hvo, aerosol, biomarkers, exposure studies, lipid peroxidation, renewable diesel, Fossil Fuels, Derivatives, and Related Products: Crude-Oil Refining and other aspects.Recommanded Product: 27115-50-0

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On October 31, 2010, Mannocci, Luca; Melkko, Samu; Buller, Fabian; Molnar, Ilona; Gapian Bianke, Jean-Paul; Dumelin, Christoph E.; Scheuermann, Jorg; Neri, Dario published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library. And the article contained the following:

Collections of chem. compounds, individually attached to unique DNA fragments serving as amplifiable identification bar codes, are generally referred to as “DNA-encoded chem. libraries”. Such libraries can be used for the de novo isolation of binding mols. against target proteins of interest. Here, we describe the synthesis and use of a DNA-encoded library based on benzamidine analogs, which allowed the isolation of a trypsin inhibitor with an IC50 value of 3.0 nM, thus representing a >10 000-fold potency improvement compared to the parental compound The novel trypsin inhibitor displayed an excellent selectivity toward other serine proteases. This study indicates that DNA-encoded libraries can be used for the facile “affinity maturation” of suboptimal binding compounds, thus facilitating drug development. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to trypsin inhibitor benzamidine derivative dna encoded library, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

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Kwon, Jae-Woo; Park, Hee-Won; Kim, Woo Jin; Kim, Man-Goo; Lee, Seung-Joon published an article in 2018, the title of the article was Exposure to volatile organic compounds and airway inflammation.Safety of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

Exposure to low levels of volatile organic compounds (VOCs) in ordinary life is suspected to be related to oxidative stress and decreased lung function. This study evaluated whether exposure to ambient VOCs in indoor air affects airway inflammation. Thirty-four subjects from the hospital that had moved to a new building were enrolled. Symptoms of sick building syndrome, pulmonary function tests, and fractional exhaled nitric oxide (FeNO) were evaluated, and random urine samples were collected 1 wk before and after the move. Urine samples were analyzed for VOC metabolites, oxidative stress biomarkers, and urinary leukotriene E4 (uLTE4) levels. The level of indoor VOCs in the new building was higher than that in the old building. Symptoms of eye dryness and eye irritation, as well as the level of a xylene metabolite (o-methylhippuric acid) increased after moving into the new building (p = 0.012, p = 0.008, and p < 0.0001, resp.). For the inflammatory markers, FeNO decreased (p = 0.012 and p = 0.04, resp.) and the uLTE4 level increased (p = 0.005) after the move. Exposure to a higher level of VOCs in everyday life could affect airway inflammation. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to volatile organic compound airway inflammation, inflammation, oxidative stress, sick building syndrome, spirometry, volatile organic compounds, Air Pollution and Industrial Hygiene: Air Pollutants and Air Pollution and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

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On June 30, 2015, Suhasini, K. P.; Christopher, V.; Rao, S. Rama Mohana; Kumar, Ch. Praveen; Murthy, Y. L. N. published an article.COA of Formula: C10H11NO3 The title of the article was Synthesis, characterisation and antitubercular screening of 5(4H)-oxazolone derivatives. And the article contained the following:

In search of new antitubercular agents, a new series of 4-(substituted benzylidene)-2-p-tolyloxazol-5(4H)-ones I [R = C6H5, 4-H3CC6H4, 4-CH3OC6H4, 2,5-(CH3O)2C6H3, 2,4,6-(CH3O)3C6H2, 4-ClC6H4, 4-BrC6H4, O2NC6H4] has been designed, synthesized and subjected to evaluate their antitubercular activity for the first time against Mycobacterium tuberculosis H37Rv, in comparison with standard drugs Rifampicin and Isoniazid. The out-put of these studies disclosed that all the synthesized target mols. I of the series displayed good to moderate activity with MIC values ranging 8-64 U+03BCg/mL. Compound I [R = 2,4,6-(CH3O)3C6H2] having three methoxy groups, is the most distinctive compound identified, amongst the series because of its remarkable in vitro antitubercular activity and thus may act as a promising lead mol. for further explorations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to oxazolone preparation antitubercular, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.COA of Formula: C10H11NO3

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Huang, Wenhua; Dong, Guangping; Mijiti, Zumureti published an article in 2012, the title of the article was One-pot synthesis of 2,4,5-trisubstituted oxazoles from N-acyl amino acids by a combination of cyclodehydration with N,N’-diisopropylcarbodiimide and Wittig olefination.Quality Control of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

By a combination of cyclodehydration of N-acyl amino acids with N,N’-diisopropylcarbodiimide (DIC) and non-classical Wittig olefination of the resultant 5(4H)-oxazolones with Ph3P=CHCN and Ph3P=CHCOOEt, 5-oxazoleacetonitriles and 5-oxazoleacetates were synthesized in one-pot in 41-85% and 57-70% yields, resp. E.g., reaction of 4-MeC6H4CONHCH2CO2H with Ph3P:CHCN in presence of DIC gave 85% 5-oxazoleacetonitrile (I). The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Quality Control of 2-(4-Methylbenzamido)acetic acid

The Article related to acyl amino acid cyclodehydration wittig olefination, oxazoleacetonitrile preparation, oxazoleacetate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Quality Control of 2-(4-Methylbenzamido)acetic acid

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Amide – an overview | ScienceDirect Topics

On June 30, 2015, Suhasini, K. P.; Christopher, V.; Kumar, Ch. Praveen; Rao, S. Rama Mohana; Murthy, Y. L. N. published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis, characterisation and antimycobacterial screening of 5(4H)-oxazolone derivatives against M. tuberculosis H37Rv. And the article contained the following:

A series of 4-(substituted benzylidene)-2-p-tolyloxazol-5(4H)-ones I [R = H, 4-Cl, 2,5-(OCH3)2, etc.] has been designed, synthesized and subjected to evaluate their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in comparison with standard drugs Rifampicin and Isoniazid. The out-put of these studies disclosed that all the synthesized target mols. of the series displayed good to moderate activity with MIC values ranging 8-64 U+03BCg/mL. The compound I [R = 2,4,6-(OCH3)3] is the most distinctive compound identified, amongst the series because of its remarkable in vitro antimycobacterial activity and thus may act as a promising lead mol. for further explorations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to oxazolone preparation antimycobacterial, methylbenzamido acetic acid preparation aldehyde aryl erlenmeyer plochl azlactone, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

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Amide – an overview | ScienceDirect Topics

On January 31, 2018, Fadavi, Abdulhamid; Zarei, Maaroof published an article.Related Products of 27115-50-0 The title of the article was One-pot Vilsmeier reagent-mediated multicomponent reaction: A direct synthesis of oxazolones and Erlenmeyer azlactones from carboxylic acids. And the article contained the following:

N-Acylation of glycine with carboxylic acids RC(O)OH [R = C6H5, 4-pyridyl, 2-naphthyl, CH3CH=CH, etc.] was carried out by using the Vilsmeier reagent. The resulting N-acyl-α-amino acids RC(O)NHCH2C(O)OH were subsequently cyclodehydrated into oxazol-5-ones I via the Vilsmeier reagent. Finally, treatment of oxazol-5-ones I with aldehydes R1CHO [R1 = CH3, C6H5, 2-furyl, etc.] in the presence of the Vilsmeier reagent delivered Erlenmeyer azlactones II. By combining these steps, using the Vilsmeier reagent allowed direct one-pot conversion of carboxylic acids RC(O)OH into oxazol-5-ones I and direct one-pot conversion of carboxylic acids RC(O)OH into Erlenmeyer azlactones in the presence of aldehydes R1CHO. These Vilsmeier reagent-mediated multicomponent reactions proceeded smoothly in reasonable chem. yields at room temperature The chem. structure of the title compounds I and II was confirmed by spectral data. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to azlactone preparation, carboxylic acid glycine aldehyde vilsmeier multicomponent, oxazolone preparation, glycine carboxylic acid vilsmeier multicomponent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Related Products of 27115-50-0

Referemce:
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Amide – an overview | ScienceDirect Topics

On July 31, 2017, Topkaya, Derya; Alp, Serap published an article.HPLC of Formula: 27115-50-0 The title of the article was New Chromophore Systems from Coumarin-Oxazol-5-one Combination. And the article contained the following:

Coumarin-oxazol-5-one (COX), I [Ar = C6H5, naphthalen-1-yl, 4-O2NC6H4, 4-H3CC6H4], were synthesized with 7-methoxy-2-oxo-2H-chromene-4-carbaldehyde and benzoylglycine derivatives ArC(O)NHCH2C(O)OH. The characterizations of the COX derivatives I by 1H NMR, FT-IR and elemental anal. were achieved. The photophys. data of the synthesized COX derivatives I were obtained using spectrophotometric and spectrofluorimetric methods. Evaluation of the absorption and emission properties of the structures was carried out in different solvents. Maximum absorption and emission wavelengths (λ; nm), molar extinction coefficients (ε; cm-1 M-1), Stoke’s shifts (ΔλST; nm) and quantum yields (ΦF) of the COX derivatives I were declared. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to coumarin oxazolone preparation diastereoselective, aroyl glycine methoxy oxo chromene carbaldehyde heterocyclization, chromophore, coumarin, oxazol-5-one, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.HPLC of Formula: 27115-50-0

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Amide – an overview | ScienceDirect Topics

Liu, Jian; Wen, Yu; He, Fengjun; Gao, Liang; Gao, Lina; Wang, Junwei; Wang, Xiachang; Zhang, Yinan; Hu, Lihong published an article in 2019, the title of the article was Ruthenium(II)-catalyzed C-O/C-S cyclization for the synthesis of 5-membered O-containing and S-containing heterocycles.COA of Formula: C10H11NO3 And the article contains the following content:

An efficient and convenient method for the synthesis of oxazole derivatives from enamides has been established via a ruthenium-catalyzed C-O cyclization. This protocol allows for a wide functional group compatibility, broad substrate scope and ease of operation. This catalytic method is also applicable to other 5-membered O-containing and S-containing heterocyclic systems involving thiazole and furan scaffolds, thus this strategy can be broadly applied to organic synthesis and medicinal chem. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to oxazole furan thiazole preparation, enamide oxidative cyclization ruthenium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C10H11NO3

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Amide – an overview | ScienceDirect Topics