Category: 2670-38-4

Potential radioprotective agents-V. Melatonin analogs. Oral activity of p-aminopropiophenone and its ethylene ketal was written by Blickenstaff, Robert T.;Reddy, Shailaja;Witt, Robert. And the article was included in Bioorganic & Medicinal Chemistry in 1994.Category: amides-buliding-blocks This article mentions the following:

Seven new amides of 5-methoxytryptamine were synthesized and tested for radioprotective activity in mice. One of them, the heptafluorobutyramide 4, is moderately active (57% survivors); the rest demonstrate little or no activity. Of twelve compounds that had been found to exhibit high radioprotective activity by i.p. injection, only two [p-aminopropiophenone (9) and its ethylene ketal 8] retain that high activity (92-95% survivors) when administered orally. Three are moderately active: p-aminobenzonitrile (10, 55%), 5-methoxytryptamine octanoic amide (11, 50%), and p-aminobenzophenone (12, 48%). In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Category: amides-buliding-blocks).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Phytotoxicity and selectivity of action of a homologous series of N-alkyl- and N,N-dialkyl-3,4-dichlorobenzamides was written by Baruffini, A.;Pagani, G.;Caccialanza, G.;Gialdi, F.. And the article was included in Farmaco, Edizione Scientifica in 1971.Recommanded Product: 3,4-Dichlorobenzamide This article mentions the following:

Of the 45 N-alkyl- and N,N-dialkyl-3,4-dichlorobenzamides (I) prepared by usual methods and tested for pre- and post-emergence phytotoxicity against common weeds, N,N-di-sec-butyl-3,4-dichlorobenzamide (6 kg/ha) selectively inhibited the growth of Echinochloa crus-galli and Setaria glauca. Most compounds were inactive in pre-emergence tests, while in the post-emergence tests some activity was shown by N-sec-amyl-3,4-dichlorobenzamide, N-sec-butyl-3,4-dichlorobenzamide, and 3,4-dichloro-N-ethylbenzamide. The N-monoalkyl-3,4-dichlorobenzamides generally showed limited action only through foliar absorption, while the more active N-dialkyl-3,4-dichlorobenzamides were absorbed through both leaves and roots. In both cases, the degree of absorption and activity is related to the structure of the alkyl residue on the N, particularly in the case of the dialkyl compounds In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 3,4-Dichlorobenzamide).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 3,4-Dichlorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mild, rapid and efficient metal-free synthesis of 2-aryl-4-aryloxyquinolines via direct C²_sp-O bond formation by using diaryliodonium salts was written by Nahide, Pradip D.;Solorio-Alvarado, Cesar R.. And the article was included in Tetrahedron Letters in 2017.Product Details of 2670-38-4 This article mentions the following:

An efficient ligand- and transition metal-free procedure for the direct C²_sp-O bond formation for the arylation of 2-aryl-4-quinolones I (R = 3,5-difluorophenyl, benzo[d][1,3]dioxol-5-yl, 4-chlorophenyl, etc.) was developed. The synthesis of the starting quinolones I was carried out under our optimized Cu-catalyzed C-N bond formation conditions between 2′-bromoacetophenone and benzamide derivatives RC(O)NH₂ followed by cyclization. Easily prepared diaryliodonium salts C₆H₅I(X)(C₆H₄R¹) (R¹ = 4-NO₂, 4-CF₃, 2-Br; X = OTf, NO₃) were used as aryl source. Highly functionalized 4-aryloxyquinolines II were obtained in a mild and operationally simple protocol, which involves conventional heating and short periods of time. The method shows good to excellent yields and broad toleration of functional groups like fluorine or trifluoromethyl, which are important in medicinal chem. The C²_sp-O bond formation process herein described for the quinolone functionalization offers an excellent non-toxic alternative to the transition metal-catalyzed reactions that not only can potentially contaminate the final compounds but also can be environmental pollutants. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Product Details of 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Supported palladium catalyzed aminocarbonylation of aryl iodides employing bench-stable CO and NH₃ surrogates was written by Shaifali;Sheetal;Bains, Rohit;Kumar, Ajay;Ram, Shankar;Das, Pralay. And the article was included in Organic & Biomolecular Chemistry in 2020.SDS of cas: 2670-38-4 This article mentions the following:

A simple, efficient and phosphine free protocol for carbonylative synthesis of primary aromatic amides under polystyrene supported palladium (Pd@PS) nanoparticle (NP) catalyzed conditions has been demonstrated. Herein, instead of using two toxic and difficult to handle gases simultaneously, we have employed the solid, economical, bench stable oxalic acid as the CO source and ammonium carbamate as the NH₃ source in a single pot reaction. For the first time, we have applied two non-gaseous surrogates simultaneously under heterogeneous catalyst (Pd@PS) conditions for the synthesis of primary amides using an easy to handle double-vial (DV) system. The developed strategy showed a good functional group tolerance towards a wide range of aryl iodides and afforded primary aromatic amides in good yields. The Pd@PS catalyst was easy to sep. and can be recycled up to four consecutive runs with small loss in catalytic activity. We have successfully extended the scope of the methodol. to the synthesis of isoindole-1,3-diones from 1,2-dihalobenzene, 2-halobenzoates and 2-halobenzoic acid following double and single carbonylative cyclization approaches. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4SDS of cas: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia was written by Jagtap, Ajit Dhananjay;Chang, Pei-Teh;Liu, Jia-Rong;Wang, Hsiao-Chun;Kondekar, Nagendra B.;Shen, Li-Jiuan;Tseng, Hsiang-Wen;Chen, Grace Shiahuy;Chern, Ji-Wang. And the article was included in European Journal of Medicinal Chemistry in 2014.Safety of 3,4-Dichlorobenzamide This article mentions the following:

A series of 6-acylureido derivatives containing a 3-(pyrrol-2-ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2-one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2-fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide I was identified as a dual Aurora B/FLT3 inhibitor (IC₅₀ = 0.4 nM and 0.5 nM, resp.). Compound I also exhibited potent cytotoxicity with single-digit nanomolar IC₅₀ values against the FLT3 mutant-associated human acute myeloid leukemia (AML) cell lines MV4-11 (FLT3-ITD) and MOLM-13 (FLT3-ITD). Compound I also specifically induced extrinsic apoptosis by inhibiting the phosphorylation of the Aurora B and FLT3 pathways in MOLM-13 cells. Compound I had a moderate pharmacokinetic profile. The mesylate salt of I efficiently inhibited tumor growth and reduced the mortality of BALB/c nude mice (s.c. xenograft model) that had been implanted with AML MOLM-13 cells. Compound 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunitinib-resistant FLT3-ITD AML cells. This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Safety of 3,4-Dichlorobenzamide).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Safety of 3,4-Dichlorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of 3,4-difluorobenzonitrile was written by Chen, Qiang;Zhang, Shaohui;Cheng, Zhiming. And the article was included in Jingxi Huagong Zhongjianti in 2006.Recommanded Product: 2670-38-4 This article mentions the following:

3,4-Difluorobenzonitrile is an important intermediate of selective herbicide, cyhalofop Bu. 3,4-Difluorobenzonitrile was synthesized by 3,4-dichlorobenzoyl chloride through amidation, dehydration and fluorination. The yield was 39.8%, and the content was 99.0%. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sequential One-pot Method for the Synthesis of 4-(Hydroxymethyl)oxazoles and their Application in Phosphonates Synthesis was written by Kajol, Km;Ramesh, Chintakunta. And the article was included in Asian Journal of Organic Chemistry in 2021.SDS of cas: 2670-38-4 This article mentions the following:

A sequential one-pot method for the synthesis of 4-(hydroxymethyl)oxazoles from readily available benzamides was developed. Various substituted benzamides well-tolerated and furnished 4-(hydroxymethyl)oxazoles in moderate to good yields under the present reaction conditions. In order to demonstrate the usefulness of the present methodol., the resulting 4-(hydroxymethyl)oxazoles were successfully transformed into its corresponding phosphonates under Michaelis-Arbuzov reaction conditions. This methodol. featured a broad substrate scope, step economy, ease of execution, and scalability. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4SDS of cas: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mechanically Flexible Organic Crystals Achieved by Introducing Weak Interactions in Structure: Supramolecular Shape Synthons was written by Krishna, Gamidi Rama;Devarapalli, Ramesh;Lal, Garima;Reddy, C. Malla. And the article was included in Journal of the American Chemical Society in 2016.Formula: C7H5Cl2NO This article mentions the following:

Controlling mech. properties of ordered organic materials remains a formidable challenge, despite their great potential for high performance mech. actuators, transistors, solar cells, photonics, and bioelectronics. A crystal engineering approach to design mech. reconfigurable, plastically flexible single crystals (of ∼10) of 3 unrelated types of compounds was demonstrated by introducing active slip planes in structures via different noninterfering supramol. weak interactions, van der Waals (vdW), π-stacking, and H bonding groups. Spherical hydrophobic groups, which assemble via shape complementarity (shape synthons), reliably form low energy slip planes, thus facilitating an impressive mech. flexibility, which allowed molding the crystals into alphabetical characters to spell out o r g a n i c c r y s t a l. The study, which reports the preparation of exotic plastic crystals by design, demonstrates the potential of soft interactions for tuning the mech. behavior of ordered mol. materials, including those from π-conjugated systems. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Formula: C7H5Cl2NO).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Formula: C7H5Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH₂-Oxygenation of Free Amines was written by Ghosh, Santanu;Jana, Chandan K.. And the article was included in Journal of Organic Chemistry in 2018.Category: amides-buliding-blocks This article mentions the following:

Direct oxidation of α-CH₂ group of free amines is hard to achieve due to the higher reactivity of amine moiety. Therefore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence or absence of hazardous oxidants under sensitive reaction conditions. A novel method for direct C-H oxygenation of aliphatic amines through a metal-free activation of mol. oxygen has been developed. Both activated and unactivated free amines were oxygenated efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationally simple conditions without the aid of metallic reagents and toxic oxidants. The method has been applied to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Category: amides-buliding-blocks).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles was written by Liu, Jianzhong;Zhang, Cheng;Zhang, Ziyao;Wen, Xiaojin;Dou, Xiaodong;Wei, Jialiang;Qiu, Xu;Song, Song;Jiao, Ning. And the article was included in Science (Washington, DC, United States) in 2020.Reference of 2670-38-4 This article mentions the following:

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chem. nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Reference of 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics