Category: 2603-10-3

Related Products of 2603-10-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2603-10-3 as follows.

7.5 g methyl phenyl carbamate (MPC) was added to 50 mL single-necked flask, 20 mL of dimethyl carbonate was added, heated at 60 and dissolved. 10 mL of concentrated hydrochloric acid (37% w / w) was added, 10mL formaldehyde solution (mass concentration of 36%), was added and reacted for two hours. After the reaction was completed, the solid was filtered, the filtrate was analyzed by high performance liquid chromatography, the contents of phenyl carbamate and diphenylmethane dicarbamate (MDC) were determined. The solid was washed three times with 50 ml of water, vacuum dried at 80 for 48h. A small amount of solid samples were taken and content and purity of diphenylmethane dicarbamate were determined. Analysis results showed that MPC conversion was 99%, MDC yield was 97% and selectivity was 98%.

According to the analysis of related databases, 2603-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sinopec Corporation; Nan Hua Group Institute; Ding Hongxia; Jin Yucun; Jin Hanqiang; Wu Qijian; Chen Yongping; Liu Zhuo; He Yumiao; (7 pag.)CN107434774; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2603-10-3, name is Methyl N-Phenylcarbamate, A new synthetic method of this compound is introduced below., Quality Control of Methyl N-Phenylcarbamate

Aniline 4650 g, dimethyl carbonate 226.7 g,Zinc acetate 3.65 g in turn into the reactor,After replacing with nitrogen and pressurized to 0.2 Mpa, heated to 180 C,Reaction at this temperature for 5 h.After completion of the reaction, the temperature of the reactor was reduced to 80 C and constant temperature,To the autoclave, add 40 mL of concentrated hydrochloric acid,A constant-flow pump was added dropwise with an aqueous formaldehyde solution (40% by mass) at a dropping rate of 0.15 mL / min,The dropping time is 100 min. After completion of the dropwise addition, the reaction was continued at 80 C for 2 h.After completion of the reaction, the reaction solution was analyzed by high performance liquid chromatography,The yield of methyl 4,4′-diphenylmethane dicarbamate was 67%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Research Institute of Nanjing Chemical Industry Group; ina Petroleum & Chemical Corporation; JIN, YUCUN; JIN H, ANQIANG; WU, QIJIAN; CHEN, YONGPING; LIU, ZHUO; HE, YUMIAO; (4 pag.)CN106543038; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2603-10-3, name is Methyl N-Phenylcarbamate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 2603-10-3

General procedure: The urethane 1 (0.66 mmol) was dissolved in dry toluene (2 mL). The alcohol (3 equiv, 1.98 mmol) and the base (1.2 equiv,0.79 mmol) were added and the reaction mixture was heated at 60C with continuous agitation during 20h. To isolate thepure product, water (10 mL) and ethyl acetate (10 mL) were added to the reaction mixture. The organic layer was separated,dried on magnesium sulfate and the solvent was evaporated. The residue was purified by silica column chromatographyeluting with a 10-50% ethyl acetate/cyclohexane gradient. The fractions were concentrated under reduced pressure to givethe desired product 2.

According to the analysis of related databases, 2603-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rhone, Benoit; Semetey, Vincent; Synlett; vol. 28; 15; (2017); p. 2004 – 2007;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 2603-10-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2603-10-3 as follows.

In a fixed bed reactor, 20 g of a supported heteropoly solid acid catalyst having a phosphomolybdic acid content of 1% added, the dimethyl carbonate was continuously added to a fixed bed reactor with a pump, and the temperature was raised to 80 C. Respectively, the preheating mass concentration of 5% phenylcarbamic acid methyl ester-dimethyl carbonate solution and concentration 10% formaldehyde solution to 80 C and simultaneously with a pump in a fixed bed reactor, Adjust the flow rate of phenylcarbamic acid methyl ester-dimethyl carbonate solution 0.4 ml/min, formaldehyde solution flow rate of 0.1 ml/min, Under normal pressure conditions for continuous condensation reaction, reaction material timing sampling analysis,MDC conversion rate of 99. 1%,The selectivity was 81.6%.Distillation crystallization gave dimethyl 4,4′-diphenylmethane dicarbamate.

According to the analysis of related databases, 2603-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Petroleum & Chemical Corporation; Research Institute of Nanjing Chemical Industry Group; He, yu miao; Jin, Hanjiang; Wu, Qijian; Jin, Yu Cun; Liu, Zhuo; Chen, Yongping; (5 pag.)CN106565545; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics