Category: 25900-61-2

Adding a certain compound to certain chemical reactions, such as: 25900-61-2, name is 3-Amino-N-methylbenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25900-61-2, Recommanded Product: 3-Amino-N-methylbenzamide

Step 4 Synthesis of 3-{2-[4-(5-Fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-oxo-acetylamino}-N-methyl-benzamide [4-(5-Fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-oxo-acetyl chloride (105 mg, 0.286 mmol) (prepared by the similar method described in example 57, Step-2 using 5-Fluoro-2-trifluoromethyl-phenyl)-piperazin-1-yl-methanone hydrochloride salt as starting material which is being prepared by the general method mentioned in the earlier examples using 5-fluoro-2-trifluoromethyl benzoic acid as starting material, Aldrich, St. Louis, Mo.) in DCM (2.5 mL) was added to cold(0 C.) solution of 3-Amino-N-methyl-benzamide (43 mg, 0.28 mmol), Et3N (86 mg, 0.12 mL, 0.86 mmol) in DCM (2.5 mL) and stirring was continued at ambient temperature for 2 hr. The reaction mixture was diluted with DCM, washed with cold water, followed by 2N HCl and brine solution. The organic layer thus collected was dried over sodium sulphate, concentrated under reduced pressure to afford the residue. The residue obtained was purified by recrystallisation from a mixture of ethyl acetate and hexane to afford 70 mg (51.09%) of 3-{2-[4-(5-Fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-oxo-acetylamino}-N-methyl-benzamide. LCMS Purity: 99.7%. 1H NMR (DMSO-d6): delta 10.95 (d, 1H), 8.4 (m, 1H), 8.2-8.0 (d, 1H), 8.6-7.9 (m, 1H), 7.8-7.6 (m, 1H), 7.6-7.4 (m, 4H), 3.9-3.4 (m, 6H), 3.3-3.1 (m, 2H), 2.8 (m, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Bischoff, Alexander; Subramanya, Hosahalli; Sundaresan, Kumar; Sammeta, Srinivasa Raju; Vaka, Anil Kumar; US2010/160323; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 25900-61-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25900-61-2 name is 3-Amino-N-methylbenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1To 4,6-dichloropyrimidine (500.0 mg, 3.36 mmol) and 3-amino-N-methylbenzamide (504 mg, 3.36 mmol) in 2-propanol (5.00 mL) at RT was added N,N-diisopropylethylamine (0.877 mL, 5.03 mmol). The resulting reaction mixture was heated at 80 C for 3 days, cooled to RT, concentrated, purified using MPLC (25 g cartridge, 40 g column, 0 to 100% EtOAc- hexanes then 30-100% 90: 10 CH2Cl2-MeOH in CH2C12). Fractions with product were combined and concentrated giving 3-(6-chloropyrimidin-4-ylamino)-N-methylbenzamide (815.2 mg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-N-methylbenzamide, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 25900-61-2, name is 3-Amino-N-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Amino-N-methylbenzamide

General procedure: To a solution of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-indazole-4-carboxylic acid (8, 30 mg,0.082 mmol) in pyridine (3 mL) at 0 C. POCl3 (12 L, 0.090 mmol) was added, and the mixture wasstirred at 0 C for 1 h. Aniline was added into the reaction mixture and stirred at 0 C for 10 min, then,the mixture was stirred at 25 C for 1.5 h. The reaction was quenched with distilled water, and theorganic phase was washed with water, 1N HCl and brine, dried over Na2SO4, filtered and concentratedin vacuo. The resultant residue was purified by column chromatography to get the final product as awhite solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25900-61-2, its application will become more common.

Reference:
Article; Zhang, Zhen; Zhao, Dongmei; Dai, Yang; Cheng, Maosheng; Geng, Meiyu; Shen, Jingkang; Ma, Yuchi; Ai, Jing; Xiong, Bing; Molecules; vol. 21; 10; (2016);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 25900-61-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25900-61-2 as follows.

Step 2To 2-chloro-5-fluoro-4-(3-(4-fluorophenoxy)azetidin-l-yl)pyrimidine (90.0 mg, 0.302 mmol) and 3-amino-N-methylbenzamide (49.9 mg, 0.333 mmol) in a disposable sealed tube in 2-propanol (2.50 mL) was added trifluoroacetic acid (0.070 mL, 0.907 mmol). The resulting reaction mixture was heated at 84 C for 3 d, cooled to RT and concentrated. The residue was stirred in EtOAc and saturated aqueous NaHC03 for 10 min and transferred to a separatory funnel. The organic layer was washed with brine, dried and concentrated giving 3-(5-fluoro-4- (3 -(4-fluorophenoxy)azetidin- 1 -yl)pyrimidin-2-ylamino)-N-methylbenzamide ( 124.8 mg).

According to the analysis of related databases, 25900-61-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25900-61-2, name is 3-Amino-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 25900-61-2

Step 2 To 2-chloro-4-(3-(4-fluorophenoxy)azetidin-l-yl)pyridine (90 mg, 0.323 mmol) and 3- amino-N-methylbenzamide (72.7 mg, 0.484 mmol) in 2-propanol (3.00 mL) in a disposable sealed tube at RT was added trifluoroacetic acid, (0.075 mL, 0.969 mmol). The resulting reaction mixture was heated at 84 C for 5 days and 92 C for 20 days, cooled to RT, concentrated, purified using MPLC (5 g cartridge, 12 g column, 0 to 100% 90/10 CH2CI2- MeOH in CH2CI2) giving 3-(4-(3-(4-fluorophenoxy)azetidin-l-yl)pyridin-2-ylamino)-N- methylbenzamide (73.6 mg).

The synthetic route of 25900-61-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 25900-61-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25900-61-2 name is 3-Amino-N-methylbenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1To 4,6-dichloropyrimidine (500.0 mg, 3.36 mmol) and 3-amino-N-methylbenzamide (504 mg, 3.36 mmol) in 2-propanol (5.00 mL) at RT was added N,N-diisopropylethylamine (0.877 mL, 5.03 mmol). The resulting reaction mixture was heated at 80 C for 3 days, cooled to RT, concentrated, purified using MPLC (25 g cartridge, 40 g column, 0 to 100% EtOAc- hexanes then 30-100% 90: 10 CH2Cl2-MeOH in CH2C12). Fractions with product were combined and concentrated giving 3-(6-chloropyrimidin-4-ylamino)-N-methylbenzamide (815.2 mg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-N-methylbenzamide, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 25900-61-2, name is 3-Amino-N-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-Amino-N-methylbenzamide

A solution of 7-methanesulfinyl-3-(2,6-dichloro-phenyl)-1-methyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine (0.10 g, 0.28 mmol), N-methyl-3-amino-benzamide (84 mg, 0.56 mmol) and p-toluenesulfonic acid monohydrate (53.3 mg, 0.28 mmol) (Aldrich) in isopropanol (4 ML) was placed in a microwave reactor (SmithSynthesizer).The reaction mixture was heated at 170 C. for 1 h.The reaction mixture was concentrated and purified by RP-HPLC (C-18, eluding with MeCN/H2O) to obtain a solid which was recrystallized from methanol to afford the product. (Yield 34 mg, 28%). HRMS m/z Calculated for C20H16Cl2N6O2 [(M+H)+]: 443.0785. Found: 443.0791.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25900-61-2, its application will become more common.

Reference:
Patent; Chen, Jian Jeffrey; Luk, Kin-Chun Thomas; US2004/97493; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 25900-61-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25900-61-2, name is 3-Amino-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 9; N-(2-Diethylamino-ethyl)-4-(3-indan-5-yl-3H-[1 ,2,3]triazolo[4,5-d]- pyrimidin-5-ylamino)-benzamide (7); To a solution of 2,4-dichloro-5-nitropyrimidine (25.0 mg, 0.13 mmol) in THF (0.2 mL) was added a solution of 3-amino-N-methyl-benzamide (19.5 mg, 0.13 mmol) in isopropyl alcohol (0.5 mL)/dimethylformarnide (0.3 mL), and CsHCO3 (25.2 mg, 0.13 mmol) in water (0.016 mL total volume). The mixture was stirred at rt for 1.5 hr at which time 4-amino-N-(2-diethylamino-ethyl)-benzamideEtaCl (procainamide hydrochloride) (38.9 mg, 0.14 mmol) in isopropyl alcohol (0.5 mL)/dimethylformamide (0.3 mL) was added. The mixture was stirred at 50C for 20 hr, cooled to rt, and acetic acid (0.1 mL) was added. To the resulting slurry was added Zn dust (45 mg, 0.69 mmol); after stirring for 15 min at rt, the reaction solution was loaded onto a 1 g silica gel SPE cartridge and eluted with 6 mL of MeOH. The eluent was concentrated at reduced pressure, dried at approximately 1 mm Hg for 18 hr, and re-suspended in MeOH (1.0 mL). To this slurry was added HOAc (0.05 mL) and sodium nitrite (0.09 g, 1.3 mmol) in water (total volume 0.2 mL). The mixture was stirred at rt for 11 hr, loaded onto a 1 g C-18 SPE cartridge, and eluted with 6 mL of MeOH. The eluent was concentrated and the resulting residue was purified by reverse-phase liquid chromatography using a gradient of 90:10 (water:acetonitrile, with 0.1% TFA) to 10:90 (wateracetonitrile, with 0.1% TFA) to furnish (7) (0.0128 g, 0.018 mmol) as the bis TFA salt. HRMS (ES-TOF) calcd. for C25H30N9O2 m/z 488.2522 (M+H),+ found: 488.2514

The synthetic route of 3-Amino-N-methylbenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/76442; (2006); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 25900-61-2, name is 3-Amino-N-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 25900-61-2

Example 69 Preparation of 1-(3-Methylcarbamoylphenyl)-3-phenylurea(Compound No. 182 in Table 2) Phenylisocyanate (209 mg) and 3-aminobenzoylmethylamide (239 mg) were dissolved in dimethylformamide (2 ml). After starring for 6 hours at room temperature, dilute hydrochloric acid (15 ml) was added. The obtained crystals were filtered and washed with water to obtain crude crystals. The crude crystals were dried under reduced pressure and added to ethyl acetate (8 ml), and the mixture was heated under reflux for 10 minutes. The mixture was cooled to room temperature, and the crystals were collected by filtration and washed with ethyl acetate to obtain the desired compound (386 mg, yield 90%). Melting Point: 209-210 C.; IR(KBr, cm-1): 3328, 3279, 1699, 1626, 1557; NMR(DMSO-d6, delta): 2.75(d, J=4.1 Hz, 3H), 6.95(dd, J-7.3 Hz, 7.3 Hz, 1H), 7.20-7.45(m, 6H), 7.57(d, J=7.7 Hz, 1H), 7.86(s, 1H), 8.37(d, J=4.1 Hz, 1H), 8.67(s, 1H), 8.79(s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25900-61-2, its application will become more common.

Reference:
Patent; Mitsubishi Chemical Corporation; US6444849; (2002); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics