Category: 247170-19-0

The author of 《Chlorination of aniline by Pd(OAc)2/N-chloro-N-fluorobenzene-sulfonylamide》 were Zhu, Ye; Huang, Jinwen; Yang, Xianjin. And the article was published in Youji Huaxue in 2019. HPLC of Formula: 247170-19-0 The author mentioned the following in the article:

A mild method for palladium-catalyzed halogenation of acetanilide with N-chloro-N-fluorobenzenesulfonylamide (CFBSA) as a chlorinating reagent, oxidant, and novel promoting reagent was achieved. The decomposition of byproduct N-fluorobenzenesulfonylamine in the presence of Pd(OAc)2 could accelerate the process of chlorination. Preliminary mechanism investigation showed that Pd catalyzed aniline directed C-H activation lead to the ortho chlorination selectivity. A series of ortho-chlorinated anilides were obtained in 28%~82% yields.N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0HPLC of Formula: 247170-19-0) was used in this study.

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.HPLC of Formula: 247170-19-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Room temperature C(sp2)-H oxidative chlorination via photoredox catalysis》 was published in Chemical Science in 2017. These research results belong to Zhang, Lei; Hu, Xile. HPLC of Formula: 247170-19-0 The article mentions the following:

Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp2)-H bonds over C(sp3)-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug. After reading the article, we found that the author used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0HPLC of Formula: 247170-19-0)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.HPLC of Formula: 247170-19-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of C9H7ClF3NOOn March 10, 2015, Gantenbein, Markus; Hellstern, Manuel; Le Pleux, Loic; Neuburger, Markus; Mayor, Marcel published an article in Chemistry of Materials. The article was 《New 4,4′-Bis(9-carbazolyl)-Biphenyl Derivatives with Locked Carbazole-Biphenyl Junctions: High-Triplet State Energy Materials》. The article mentions the following:

We synthesized a series of 4,4′-bis(9-carbazolyl)-biphenyl (CBP) derivatives, using Me groups as spatially demanding groups, locking the angle between the carbazole subunit and the biphenyl backbone as potential matrix material for blue organic light-emitting diodes (OLEDs). The locked rotation was achieved by four Me groups either in positions 1 and 8 of the carbazole subunit (1) or in positions 3, 5, 3′, and 5′ of the biphenyl subunit (2), and the fixed spatial arrangement was confirmed by X-ray anal. The phys. properties of CBP derivatives based on parent structure 2 were further tailored by electron-withdrawing CF3 groups in positions 3 and 6 (3) or positions 2 and 7 of the carbazole subunits (4) or alternatively by electron-donating CH3O groups in positions 2 and 7 (5) of the same building blocks. Increased triplet energies (ET) compared to that of the parent compound CBP were found for all synthesized CBP derivatives 1-5. Enhanced glass transition temperatures ranging between 129 and 202 °C further corroborate the application potential of these derivatives for matrix material in blue OLEDs. In the experiment, the researchers used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Electric Literature of C9H7ClF3NO)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C9H7ClF3NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2020,Advanced Functional Materials included an article by Feng, Jiale; Yang, Lupeng; Romanov, Alexander S.; Ratanapreechachai, Jirawit; Reponen, Antti-Pekka M.; Jones, Saul T. E.; Linnolahti, Mikko; Hele, Timothy J. H.; Koehler, Anna; Baessler, Heinz; Bochmann, Manfred; Credgington, Dan. Quality Control of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide. The article was titled 《Environmental Control of Triplet Emission in Donor-Bridge-Acceptor Organometallics》. The information in the text is summarized as follows:

Carbene-metal-amides (CMAs) are a promising family of donor-bridge-acceptor mol. charge-transfer (CT) emitters for organic light-emitting diodes. A universal approach is demonstrated to tune the energy of their CT emission. A blueshift of ≤210 meV is achievable in solid state via dilution in a polar host matrix. The origin of this shift has 2 components: constraint of thermally-activated triplet diffusion, and electrostatic interactions between guest and polar host. This allows the emission of mid-green CMA archetypes to be tuned to sky blue without chem. modifications. Monte-Carlo simulations based on a Marcus-type transfer integral reproduce the concentration- and temperature-dependent triplet diffusion process, revealing a substantial shift in the ensemble d. of states in polar hosts. In Au-bridged CMAs, this shift does not lead to a significant change in luminescence lifetime, thermal activation energy, reorganization energy, or intersystem crossing rate. These discoveries offer new insight into coupling between the singlet and triplet manifolds in CMA materials, revealing a dominant interaction between states of CT character. The same approach is employed using materials which were chem. modified to alter the energy of their CT state directly, shifting the emission of sky-blue chromophores into the practical blue range. In the experiment, the researchers used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Quality Control of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids》 were Mamontov, Alexander; Martin-Mingot, Agnes; Metayer, Benoit; Karam, Omar; Zunino, Fabien; Bouazza, Fodil; Thibaudeau, Sebastien. And the article was published in Chemistry – A European Journal in 2020. Reference of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide The author mentioned the following in the article:

Site-selective functionalization of arenes that was complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2-H bonds of aromatic amines occurred. Furthermore, the superacid-promoted (poly)protonation of the mols. acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients. In the part of experimental materials, we found many familiar compounds, such as N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Reference of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jin, Lianwen; Zeng, Xiaoli; Li, Siyang; Qiu, Guofu; Liu, Peng published an article in European Journal of Organic Chemistry. The title of the article was 《Copper-Catalyzed Regioselective Halogenation of Anilides with N-Fluorobenzenesulfonimide》.Category: amides-buliding-blocks The author mentioned the following in the article:

Here described a copper-catalyzed direct chlorination and bromination of anilides in the presence of N-fluorobenzenesulfonimide as oxidant. This protocol shows excellent regioselectivity and mono-substitution with inexpensive KCl or NaBr as the halogen source and industrially friendly solvent. In addition to this study using N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide, there are many other studies that have used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Category: amides-buliding-blocks) was used in this study.

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Efficient Electrocatalysis for the Preparation of (Hetero)aryl Chlorides and Vinyl Chloride with 1,2-Dichloroethane》 were Liang, Yujie; Lin, Fengguirong; Adeli, Yeerlan; Jin, Rui; Jiao, Ning. And the article was published in Angewandte Chemie, International Edition in 2019. Related Products of 247170-19-0 The author mentioned the following in the article:

Although the application of 1,2-dichloroethane (DCE) as a chlorinating reagent in organic synthesis with the concomitant release of vinyl chloride as a useful byproduct is a fantastic idea, it still presents a tremendous challenge and has not yet been achieved because of the harsh dehydrochlorination conditions and the sluggish C-H chlorination process. Here we report a bifunctional electrocatalysis strategy for the catalytic dehydrochlorination of DCE at the cathode simultaneously with anodic oxidative aromatic chlorination using the released HCl as the chloride source for the efficient synthesis of value-added (hetero)aryl chlorides. The mildness and practicality of the protocol was further demonstrated by the efficient late-stage chlorination of bioactive mols. After reading the article, we found that the author used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Related Products of 247170-19-0)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Related Products of 247170-19-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《A Green and Sustainable Approach for Selective Halogenation of Anilides, Benzanilides, Sulphonamides and Heterocycles》 were Lakshmireddy, V. M.; Naga Veera, Y.; Reddy, T. J.; Rao, V. J.; China Raju, B.. And the article was published in Asian Journal of Organic Chemistry in 2019. COA of Formula: C9H7ClF3NO The author mentioned the following in the article:

An efficient green and sustainable protocol was devised for the selective oxidative halogenation of acetanilides, benzanilides, sulfonamides and heterocyclic compounds to afford haloanilides and halosulfonamides I [R = COMe, COPh, SO2Ph; R1 = Cl, Br; R2 = H, F; R3 = H, i-Pr, CF3, etc.; R4 = H, F, Br, etc.], haloimidazoles, haloindoles, halothiazoles and 1,2,4-triazole e.g. II and halopyridines III [R5 = NH2, NHCOMe, Br, etc.; R6 = NH2, Cl, Br, etc.; R7 = H, NH2, NH(Me)2, NHCOMe; R8 = H, Cl, Br] using easily available NaX as a halogen source and oxone as a powerful oxidant. The present protocol was simple and environmentally benign to conduct the laboratory scale halogenations and could be extended to prepare industrially important compounds In the experiment, the researchers used many compounds, for example, N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0COA of Formula: C9H7ClF3NO)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C9H7ClF3NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,European Journal of Organic Chemistry included an article by Singh, Harshvardhan; Sen, Chiranjit; Sahoo, Tapan; Ghosh, Subhash Chandra. Recommanded Product: N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide. The article was titled 《A Visible Light-Mediated Regioselective Halogenation of Anilides and Quinolines by Using a Heterogeneous Cu-MnO Catalyst》. The information in the text is summarized as follows:

A simple and practical heterogeneous Cu-MnO catalyzed regioselective halogenation of anilides and quinolines under irradiation with household 40 W incandescent lamp was developed. This method uses a recyclable Cu-MnO catalyst, acetonitrile as an industrially friendly solvent, and economic N-halo succinimides as a halogenating source. The reaction is scalable and well tolerated with a broad range of functional groups. The experimental process involved the reaction of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Recommanded Product: N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics