Category: 2447-79-2

Peng, Yanqing published the artcileAmides by microwave-assisted dehydration of ammonium salts of carboxylic acids, Synthetic Route of 2447-79-2, the publication is Organic Preparations and Procedures International (2002), 34(1), 95-97, database is CAplus.

A direct and rapid procedure for the preparation of primary amides from ammonium salts of carboxylic acids in formamide under microwave irradiation is presented. Different types of carboxylic acids were converted to their corresponding amides by this procedure with satisfactory yields. The ammonium salts of carboxylic acids were formed in situ from ammonium bicarbonate and corresponding carboxylic acids. Formamide was suitable for this procedure both as a solvent and a dehydrating agent. This procedure compares favorably to other classical methods and it has the advantages of simple work-up, short reaction time, and the use of inexpensive and readily available reagents.

Organic Preparations and Procedures International published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Allam, Bharat Kumar published the artcileHighly efficient one-pot synthesis of primary amides catalyzed by scandium(III) triflate under controlled MW, Product Details of C7H5Cl2NO, the publication is Tetrahedron Letters (2011), 52(44), 5851-5854, database is CAplus.

Primary aryl amides were prepared by amidation of aromatic aldehydes with NH₂OH.HCl by using scandium(III) triflate as a catalyst in water under controlled microwave. This methodol. offers excellent yields in shorter reaction times with enhanced selectivity.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rossi, Steven A. published the artcileSelective Formation of Secondary Amides via the Copper-Catalyzed Cross-Coupling of Alkylboronic Acids with Primary Amides, Category: amides-buliding-blocks, the publication is Organic Letters (2013), 15(9), 2314-2317, database is CAplus and MEDLINE.

For the first time, a general catalytic procedure for the cross-coupling of primary amides and alkylboronic acids is demonstrated. The key to the success of this reaction was the identification of a mild base (NaOSiMe₃) and oxidant (di-tert-Bu peroxide) to promote the copper-catalyzed reaction in high yield. This transformation provides a facile, high-yielding method for the monoalkylation of amides.

Organic Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Sen-Lin published the artcileSynthesis and bioactivity of novel pyrazole oxime derivatives containing oxazole ring, Formula: C7H5Cl2NO, the publication is Chinese Chemical Letters (2015), 26(6), 672-674, database is CAplus.

A series of novel pyrazole oxime derivatives containing oxazole ring were designed and synthesized. The title compounds were structurally confirmed by ¹H NMR, ¹³C NMR spectra and elemental analyses. Preliminary bioassay results showed that some of the title compounds displayed promising fungicidal activity besides insecticidal and acaricidal activity. Particularly, compound 8c exhibited potent fungicidal activity against cucumber Pseudoperonospora cubensis beyond good insecticidal activity against Aphis craccivora and Nilaparvata lugens.

Chinese Chemical Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C25H47NO8, Formula: C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Xie, Jianwei published the artcileTransition-metal-free decarboxylative amidation of aryl α-keto acids with diphenylphosphoryl azide: new avenue for the preparation of primary aryl amides, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Youji Huaxue (2020), 40(12), 4284-4289, database is CAplus.

In this paper, a novel transition-metal-free decarboxylative amidation of (heteroaryl)aryl α-keto acids ArC(O)C(O)OH (Ar = 2,4-dichlorophenyl, naphthalen-2-yl, thiophen-2-yl, etc.) with diphenylphosphoryl azide (DPPA) under mild conditions has been developed. The reaction proceeded smoothly to afford the corresponding primary (heteroaryl)aryl amide products ArC(O)NH₂ in good to excellent yields under air and showed excellent functional group tolerance. Gram-scale reaction was also performed to produce the desired product in high yield. In addition, the mechanism of the present reaction was investigated.

Youji Huaxue published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C12H10O4S, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sinks, Glendon D. published the artcileCorrelation of Tetrahymena and Pimephales toxicity: evaluation of 100 additional compounds, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Environmental Toxicology and Chemistry (2001), 20(4), 917-921, database is CAplus and MEDLINE.

In the summary/recommendations for the Ecotoxicol. Session of TestSmart-a Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data Workshop, it was recommended that more population growth impairment data using Tetrahymena be generated and compared with available lethality data for the fathead minnow. To comply with this recommendation, 100 addnl. chems. were tested in the ciliate assay. Toxicity values for the 96-h Pimephales promelas mortality assay (log[LC50^-1]) and the 2-d Tetrahymena pyriformis growth assay (log[IGC50^-1]) were compared. Each chem. was a priori assigned a mode of action. The majority of compounds were classified as either narcotics (n = 46) or direct-acting electro(nucleo)philes (n = 43), while 11 chems. were listed as carboxylic acids, diesters, proelectrophiles, or weak acid respiratory uncouplers. Toxicities for narcotics showed an excellent relationship between endpoints with the coefficient of determination (r²) being 0.93. A weaker relationship, r² = 0.78, was observed for the electro(nucleo)philes. The poorer fit for the covalent-reacting electro(nucleo)philes is attributed to differences in protocol, in particular, to test-medium composition and exposure scheme. Those chems. whose potency is mediated by metabolism in fish (diesters and proelectrophiles) as well as the acids exhibited a poor correlation between endpoints, with toxicity in the fish assay being greater than that predicted from the ciliate data. The regression anal. between endpoints, regardless of mode or mechanism of toxic action, yielded the model log(LC50^-1) = 1.12(log[IGC50^-1]) + 0.46, with n = 92, r² = 0.82, s (root of the mean square error) = 0.87, F = 399, and p > F = 0.0001. A result for the present investigation supports earlier findings that, with noted exceptions, there is a strong relationship between toxicity potency as quantified by P. promelas mortality and T. pyriformis growth impairment.

Environmental Toxicology and Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C10H18O, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rusu, Georgeta published the artcileAntibacterial activity of urotropin salts of the oxazolidine series, Product Details of C7H5Cl2NO, the publication is Revista Medico-Chirurgicala (1988), 92(1), 133-6, database is CAplus.

Six urotropin salts of the oxazolidine series (I; R = Ph, substituted Ph) were prepared and their antimicrobial properties were determined Good activity was evident against Staphylococcus aureus, Bacillus subtilis, and Candida albicans.

Revista Medico-Chirurgicala published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Al-Huniti, Mohammed H. published the artcileDevelopment and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles, Quality Control of 2447-79-2, the publication is Organic Letters (2018), 20(19), 6046-6050, database is CAplus and MEDLINE.

A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.

Organic Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Quality Control of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Dan published the artcileSynthesis and herbicidal activity of N-isoindoline-1,3-dione-substituted phenyl-N’-benzoyl ureas, Related Products of amides-buliding-blocks, the publication is Yingyong Huagong (2007), 36(6), 530-533, database is CAplus.

A method for the synthesis of the title compounds [i.e., N-[[[(halo)-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]amino]carbonyl]benzamide derivatives] is reported here. In search of safer and more efficiency herbicidal compounds, flumioxazin [i.e., 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione] was chosen as lead compound and eleven N-isoindoline-1,3-dione-substituted phenyl-N’-benzoyl ureas were designed and synthesized. Their structures were confirmed by IR, NMR, LC/MC and elemental anal. A preliminary bioassay showed that most of these title compounds had better herbicidal activity than the lead compound Several compounds displayed more than 80% inhibition to broad-leaf weeds, such as Abutilon theophrasti, Chenopodium album L., Amaranthus ascendens L. at 75 g/hm².

Yingyong Huagong published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Herrero, A. published the artcileDetermination of dichlobenil and its major metabolite (BAM) in onions by PTV-GC-MS using PARAFAC2 and experimental design methodology, Related Products of amides-buliding-blocks, the publication is Chemometrics and Intelligent Laboratory Systems (2014), 92-108, database is CAplus.

The optimization of a GC-MS anal. procedure which includes derivatization, Quick Easy Cheap Effective Rugged and Safe (QuEChERS) and programmed temperature vaporization (PTV) using design of experiments is performed to determine 2,6-dichlorobenzonitrile (dichlobenil) and 2,6-dichlorobenzamide (BAM) in onions, using 3,5-dichlorobenzonitrile and 2,4-dichlorobenzamide as internal standards The use of a central composite design and two D-optimal designs, together with the desirability function, makes it possible to significantly reduce the economic, time and environmental cost of the study. The usefulness of PARAFAC2 for solving problems as the interference of unexpected derivatization artifacts unavoidably linked to some derivatization agents, or the presence of coeluents from the complex matrix, which share m/z ratios with the target compounds, is shown. The limits of decision (CCα) of the optimized procedure, 5.00 μg kg^– 1 for dichlobenil and 1.55 μg kg^– 1 for BAM (α = 0.05), are below the maximum residue limit (MRL) established by the EU for dichlobenil (20 μg kg^– 1) in this commodity.

Chemometrics and Intelligent Laboratory Systems published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics