Category: 2447-79-2

Zhang, Lijun published the artcileCannizzaro-Type Disproportionation of Aromatic Aldehydes to Amides and Alcohols by Using Either a Stoichiometric Amount or a Catalytic Amount of Lanthanide Compounds, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Journal of Organic Chemistry (2006), 71(8), 3149-3153, database is CAplus and MEDLINE.

Aromatic aldehydes can be directly converted to the corresponding amides and alcs. in good to excellent yields by treatment with LiN(SiMe₃)₂ in the presence of catalytic lanthanide chlorides LnCl₃ or with a stoichiometric amount of lanthanide amides [(Me₃Si)₂N]₃Ln(μ-Cl)Li(THF)₃ at ambient temperature. The effects of solvents, substituents on the Ph ring, and lanthanide metals on the reaction have been examined The mechanism of the disproportionation reaction was proposed based on the exptl. results.

Journal of Organic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C5H10O2S, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kang, Jianlei published the artcileSynthesis of 5-[[[4-methyl-2-(phenyl)-5-thiazolyl]methyl]thio]-1,3-benzodioxole-2,2-dicarboxylic acid derivatives and determination of their activity as PPARδ agonists, Safety of 2,4-Dichlorobenzamide, the publication is Zhongguo Yaowu Huaxue Zazhi (2006), 16(4), 193-197, 207, database is CAplus.

A series of novel 1,3-benzodioxole-2,2-dicarboxylic acid derivatives were synthesized from arylamides and pyrocatechol through a ten-step process and the target compounds were screened in a cell-based transient transactivation assay against human peroxisome proliferator-activated receptor-δ (PPARδ). A series of target compounds were confirmed by fast atom bombardment mass spectrometry (FAB-MS) and ¹H-NMR. The preliminary pharmacol. screening showed that these compounds exhibited definite human PPARδ agonist activity,.

Zhongguo Yaowu Huaxue Zazhi published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Safety of 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Premkumar, Muniyappan published the artcileHalf-sandwich Ruthenium(II) Schiff base complexes: Synthesis, characterization and effective catalysts for one-pot conversion of aldehydes to amides, SDS of cas: 2447-79-2, the publication is Journal of Organometallic Chemistry (2019), 120964, database is CAplus.

Five new Schiff base ligands and conformationally rigid half-sandwich organo ruthenium(II) Schiff base complexes (1–5) with the general formula [Ru(η⁶-p-cymene)(Cl)(L_1-5)] (where, L = mono anionic Schiff base ligands) have been synthesized from the reaction of [{(η⁶-p-cymene)RuCl}₂(μ-Cl)₂] with a bidentate Schiff bases ligands. These ruthenium(II) Schiff base complexes were fully characterized by elemental anal., FT-IR, UV-Vis, ¹H & ¹³C NMR and mass spectroscopy studies. In chloroform solution, all the metal complexes exhibit characteristic metal to ligand charge transfer bands (MLCT) and emission bands in the visible region. The crystal structure of the complexes [Ru(η⁶-p-cymene)(Cl)(L₁)] (1) and [Ru(η⁶-p-cymene)(Cl)(L₃)] (3) were determined by single crystal x-ray crystallog. The complexes exhibited good catalytic activity for aldehydes to amides by one-pot conversion process in the presence of NaHCO₃/NH₂OH·HCl.

Journal of Organometallic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Papa, Ester published the artcileStatistically Validated QSARs, Based on Theoretical Descriptors, for Modeling Aquatic Toxicity of Organic Chemicals in Pimephales promelas (Fathead Minnow), Related Products of amides-buliding-blocks, the publication is Journal of Chemical Information and Modeling (2005), 45(5), 1256-1266, database is CAplus and MEDLINE.

The use of Quant. Structure-Activity Relationships in assessing the potential neg. effects of chems. plays an important role in ecotoxicol. (LC₅₀)_96h in Pimephales promelas (Duluth database) is widely modeled as an aquatic toxicity end-point. The object of this study was to compare different mol. descriptors in the development of new statistically validated QSAR models to predict the aquatic toxicity of chems. classified according to their MOA and in a unique general model. The applied multiple linear regression approach (ordinary least squares) is based on theor. mol. descriptor variety (1D, 2D, and 3D, from DRAGON package, and some calculated logP). The best combination of modeling descriptors was selected by the Genetic Algorithm-Variable Subset Selection procedure. The robustness and the predictive performance of the proposed models was verified using both internal (cross-validation by LOO, bootstrap, Y-scrambling) and external statistical validations (by splitting the original data set into training and validation sets by Kohonen-artificial neural networks (K-ANN)). The model applicability domain (AD) was checked by the leverage approach to verify prediction reliability.

Journal of Chemical Information and Modeling published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nemazanyi, A. G. published the artcileNew approach to the synthesis of polyfunctional isoquinolones, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Doklady Akademii Nauk Ukrainskoi SSR, Seriya B: Geologicheskie, Khimicheskie i Biologicheskie Nauki (1989), 36-9, database is CAplus.

The title isoquinolones I (R¹ = H, R² = NO₂, R³ = H, Me, Ph, PhCH₂, 4-MeOC₆H₄; R¹ = Cl, R² = H, R³ = H, Me; R¹-R³ = H) were prepared in 54-93% yields by treating the corresponding benzamides II (R⁴ = H, Me, X = Cl, F) with CH₂(CN)₂ in DMF containing K₂CO₃.

Doklady Akademii Nauk Ukrainskoi SSR, Seriya B: Geologicheskie, Khimicheskie i Biologicheskie Nauki published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bossi, R. published the artcileAnalysis of polar pesticides in rainwater in Denmark by liquid chromatography-tandem mass spectrometry, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Journal of Chromatography A (2002), 957(1), 27-36, database is CAplus and MEDLINE.

A new LC-MS-MS method for anal. of rainwater was developed and validated for 53 pesticides, degradation products of pesticides and selected nitrophenols. The method was used to monitor the concentration of pesticides in rainwater at one location near Roskilde, Denmark from Feb. 2000 to August 2000. Sampling was done in periods of up to 4 wk using a cooled wet-only sampler. H₂O samples were extracted by solid-phase extraction on Oasis HLB columns. The anal. of the extracts was performed by LC-MS-MS with electrospray ionization. All samples were analyzed in neg. and in pos. ionization mode, resp. for acidic and neutral compounds All analyses were done in the selected reaction monitoring mode to obtain a better signal-to-noise ratio. The method was validated for the following parameters: recovery, detection limit, uncertainty and linearity. Atrazine, terbuthylazine, isoproturon, mechlorprop and (2-methyl-4-chlorophenoxy)acetic acid were measured at concentrations >0.100 μg/l, mainly during the period of agricultural use. Nitrophenols were measured at high concentrations all year with peaks in the cold season (Feb.-Mar.).

Journal of Chromatography A published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sathyanarayana, Pochampalli published the artcileIodine-catalyzed oxidative C-C bond cleavage for benzoic acids and benzamides from alkyl aryl ketones, Recommanded Product: 2,4-Dichlorobenzamide, the publication is RSC Advances (2016), 6(27), 22749-22753, database is CAplus.

Iodine-catalyzed oxidative C-C bond cleavage has been performed for the facile synthesis of both benzoic acids and benzamides from readily available alkyl aryl ketones. Addnl. benzylidene acetones and phenylacetylenes were also converted to the corresponding aromatic acids under the same conditions. This approach features the use of inexpensive iodine as a catalyst, broad substrate scope and open air conditions.

RSC Advances published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Horley, D. published the artcileThe infrared spectra of some titanium(IV) complexes with primary diamines, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Canadian Journal of Chemistry (1965), 43(12), 3201-5, database is CAplus.

A series of Ti(IV) halide-diamine complexes was prepared and their ir spectra measured in the solid state, 300-4000 cm.^-1 The configuration of the ligand and extent of aminolysis of the Ti-halide bond are discussed in relation to the spectra. Some assignments are proposed in the 300-600-cm.^-1 region for the ethylenediamine complexes.

Canadian Journal of Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Admans, Gary published the artcileArtificial neural network for predicting the toxicity of organic molecules, COA of Formula: C7H5Cl2NO, the publication is Bulletin of the Chemical Society of Japan (2001), 74(12), 2451-2461, database is CAplus.

Structure-activity relationships for aquatic toxicity were studied using neural networks and linear regression anal. The structural features contributing to toxicity were identified in mols. exhibiting a level of toxicity greater than that of non-reactive organic mols. A neural network was trained for the toxicity of non-polar narcotics, polar narcotics, or reactive toxicants. Quant. structure-activity relationships (QSARs) were developed, relating a mol. aquatic toxicity to its log P and to a set of 16 structural descriptors based upon the presence of selected structural features. The inclusion of these structural descriptors into a QSAR was found to enhance the correlation of the equation, and thus to improve its ability for predicting aquatic toxicity.

Bulletin of the Chemical Society of Japan published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, COA of Formula: C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bose, D. Subhas published the artcileA simple method for the synthesis of nitriles from primary amides under neutral conditions, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Synthetic Communications (1999), 29(23), 4235-4239, database is CAplus.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) is a very useful reagent for the preparation of nitriles in good yields under neutral conditions. For example, dehydration of 2,4-dimethoxybenzamide gave 2,4-dimethoxybenzonitrile. Elimination reaction of 4-chlorobenzenecarbothioamide gave 4-chlorobenzonitrile.

Synthetic Communications published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics