Category: 2444-46-4

Electric Literature of C17H27NO3In 2019, Sarpras, M.;Ahmad, Ilyas;Rawoof, Abdul;Ramchiary, Nirala published 《Comparative analysis of developmental changes of fruit metabolites, antioxidant activities and mineral elements content in Bhut jolokia and other Capsicum species》. 《LWT–Food Science and Technology》published the findings. The article contains the following contents:

Humans are directly or indirectly dependent on plant foods for their nutritional health. Hence it is important to characterize the macro and micro nutrients and mineral-elements of commonly consumed dietary vegetables like Capsicum (Chilli). In the present study global metabolites, total ascorbic acid, phenols, flavonoids, capsaicinoids, mineral-elements and antioxidant activities were determined on different developmental stages of Capsicum fruits (immature, breaker and mature) belonging to three Capsicum species namely Capsicum chinense, C. frutescens, and C. annuum. The results obtained from the present study showed the maturity dependent increase in the sugar and fatty acid metabolites, capsaicinoids, ascorbic acid and phenol content, and antioxidant activities. Similarly, essential mineral-elements also increased during the fruit maturation in C. chinense, however, contrasting results was observed in C. annuum. In addition to that some health beneficial compounds such as antibacterial and antifungal metabolites exclusively observed in matured C. chinense. These interesting observations have opened the possibility to understand and manipulate biosynthesis of macro/micronutrients and mineral elements in order to improve nutritional quality of Capsicum (Chilli) species.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Electric Literature of C17H27NO3 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Sujing;Zhou, Jun;Ma, Xuanxuan;Liu, Ying;Ma, Xing;Xia, Chuanhai published 《Ecotoxicity and preliminary risk assessment of nonivamide as a promising marine antifoulant》. The research results were published in《Journal of Chemistry》 in 2016.Category: amides-buliding-blocks The article conveys some information:

The unclear environmental performance of nonivamide limits its application as a marine antifoulant. In this study, the natural degradation of nonivamide was studied in seawater and tap water. The half-life was 5.8 d, 8.8 d, 12.2 d, and 14.7 d in seawater and tap water in photolysis and biolysis, resp. Furthermore, the ecotoxicity of nonivamide was assessed using marine microalgae, Chlorella vulgaris and Platymonas sp.; EC50,6 d values on the growth of Chlorella vulgaris and Platymonas sp. were 16.9 mg L^-1 and 19.21 mg L^-1, resp. The toxicity and environmental risk of nonivamide on microalgae were significantly decreased due to the natural degradation in seawater. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Category: amides-buliding-blocks Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 2444-46-4In 2021, Fadladdin, Yousef Abdal Jalil published 《Antischistosomal activity of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa plant extracts on hamster infected with Schistosoma haematobium》. 《BioMed Research International》published the findings. The article contains the following contents:

World Health Organization (WHO) has approved only one treatment for schistosomiasis, praziquantel (PZQ), but some poor efficacy was noticed in patients during the early stage of infection. Therefore, researchers have intensified their efforts to research new alternative medicines to treat schistosomiasis. In the present study, in vitro as well as in vivo studies have been accomplished to evaluate the effect of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa extracts in a different concentration 500, 250, 125, 62.5, and 31.25 μg/mL on golden hamster infected by Egyptian strains of schistosome (Schistosoma haematobium). In vitro, the adult worms and schistosomula of S. haematobium were investigated in RPMI-1640 medium for 48 h. The results showed that the concentration 500, 250, and 125 μg/mL of Origanum majorana, and Ziziphus spina-christi caused dead of 100% of Egyptian Schistosoma strains of adult worm and schistosomula of S. haematobium within 6 to 12 h of incubation. On the other hand, the extract of Salvia fruticosa at concentrations 500, 250, and 125 μg/mL showed death 100% parasites after 12 to 24 h of incubation. Inclusion, Origanum majorana, and Ziziphus spina-christi showed effectiveness against Egyptian Schistosoma strains (S. haematobium), a slight decrease in Salvia fruticosa was observed Therefore, these medical plant extracts may be used as a safe and effective treatment for schistosomiasis. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xie, Dandan;Yang, Zaiping;Hu, Xin;Wen, Yin published 《Synthesis, antibacterial and insecticidal activities of novel capsaicin derivatives containing a sulfonic acid esters moiety》 in 2022. The article was appeared in 《Frontiers in Chemistry (Lausanne, Switzerland)》. They have made some progress in their research.Product Details of 2444-46-4 The article mentions the following:

In order to develop an efficient and broad-spectrum bactericide, a series of novel capsaicin derivatives containing a sulfonic acid esters moiety was synthesized. The structure of these compounds were confirmed by NMR spectroscopy (NMR) and high-resolution mass spectrum (HRMS). The results of the bioactivities revealed that some target compounds exhibited remarkable antibacterial activity. Compound 3b exhibited the highest activities against Pseudomonas syringae pv. actinidiae (Psa), Xanthomonas oryzae pv. oryzae (Xoo), and Xanthomonas axonopodis pv. citri (Xac), and the values were 86, 54, and 92% at 50 μg/mL, resp., which were higher than were for thiodiazole copper (87, 34, and 77%) and bismerthiazol (87, 37 and 75%). Although some compounds also showed certain activity against Spodoptera frugiperda, it was weaker than the pos. controls monosultap and mulfoxaflor. Thus, the bioassay results recommend that these newly designed and synthesized scaffolds should be used as a bactericide lead compound rather than an insecticide lead compound And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chiang, Chengyao;Zhang, Min;Wang, Dian;Xiao, Tian;Zhu, Lizhi;Chen, Kai;Huang, Junrong;Huang, Jingying;Zhu, Jiang;Li, Li;Chen, Cheng;Chen, Yangchao;Hu, Hongyi;Jiang, Wenqi;Zou, Yongdong;Wang, Ting;Zheng, Duo published 《Therapeutic potential of targeting MKK3-p38 axis with capsaicin for nasopharyngeal carcinoma》. The research results were published in《Theranostics》 in 2020.Recommanded Product: 2444-46-4 The article conveys some information:

Background: Capsaicin is an active compound found in plants of the Capsicum genus; it has a range of therapeutic benefits, including anti-tumor effects. Here we aimed to delineate the inhibitory effects of capsaicin on nasopharyngeal carcinoma (NPC). Methods: The anti-cancer effects of capsaicin were confirmed in NPC cell lines and xenograft mouse models, using CCK-8, clonogenic, wound-healing, transwell migration and invasion assays. Co-immunoprecipitation, western blotting and pull-down assays were used to determine the effects of capsaicin on the MKK3-p38 axis. Cell proliferation and EMT marker expression were monitored in MKK3 knockdown (KD) or over-expression NPC cell lines treated with or without capsaicin. Finally, immunohistochem. was performed on NPC specimens from NPC patients (n = 132) and the clin. relevance was analyzed. Results: Capsaicin inhibited cell proliferation, mobility and promoted apoptosis in NPC cells. Then we found that capsaicin directly targets p38 for dephosphorylation. As such, MKK3-induced p38 activation was inhibited by capsaicin. Furthermore, we found that capsaicin-induced inhibition of cell motility was mediated by fucokinase. Xenograft models demonstrated the inhibitory effects of capsaicin treatment on NPC tumor growth in vivo, and anal. of clin. NPC samples confirmed that MKK3 phosphorylation was associated with NPC tumor growth and lymphoid node metastasis. Conclusions: The MKK3-p38 axis represents a potential therapeutic target for capsaicin. MKK3 phosphorylation might serve as a biomarker to identify NPC patients most likely to benefit from adjunctive capsaicin treatment. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Recommanded Product: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Qin, Yeyu;Xie, Jing;Zheng, Ruihe;Li, Yuhang;Wang, Haixia published 《Oleoylethanolamide as a new therapeutic strategy to alleviate doxorubicin-induced cardiotoxicity》 in 2022. The article was appeared in 《Frontiers in Pharmacology》. They have made some progress in their research.COA of Formula: C17H27NO3 The article mentions the following:

Doxorubicin (DOX) is one of the most common chemotherapeutic anti-cancer drugs. However, its clin. use is restricted by serious cardiotoxicity. Oleoylethanolamide (OEA), a structural congener of endocannabinoid anandamide, is the endogenous agonist of peroxisome proliferator activated-receptor α (PPARα) and transient receptor potential cation channel vanilloid-1 (TRPV1), and involved in many physiol. processes. The present study aimed to determine whether OEA treatment protects against DOX-induced cytotoxicity (DIC) and gain insights into the underlying mechanism that mediate these effects. Our data revealed that Oleoylethanolamide treatment improved the myocardial structure in DOX-challenged mice by attenuating cardiac oxidative stress and cell apoptosis. OEA also alleviated DOX-induced oxidative stress and apoptosis dysregulation in HL-1 cardiomyocyte. These effects were mediated by activation of TRPV1 and upregulation of PI3K/ Akt signaling pathway. Inhibition of TRPV1 and PI3K reversed the protective effects of OEA. Taken together, our data suggested that OEA protects against DIC through a TRPV1- mediated PI3K/ Akt pathway. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.COA of Formula: C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hochkogler, Christina M.;Lieder, Barbara;Schachner, Daniel;Heiss, Elke;Schroeter, Annett;Hans, Joachim;Ley, Jakob P.;Krammer, Gerhard E.;Somoza, Veronika published 《Capsaicin and nonivamide similarly modulate outcome measures of mitochondrial energy metabolism in HepG2 and 3T3-L1 cells》 in 2018. The article was appeared in 《Food & Function》. They have made some progress in their research.Safety of N-Vanillylnonanamide The article mentions the following:

Capsaicin, the highly pungent principle of red pepper, has been demonstrated to have anti-obesity properties by affecting energy and lipid metabolism Recent evidence from human intervention trials shows that also less pungent capsaicin analogs, like nonivamide, may help to reduce total body fat, although mechanistic data comparing the effects of capsaicin and nonivamide on outcome measures of energy metabolism are lacking. Here, the tissue-specific effects of capsaicin and nonivamide on parameters of mitochondrial energy metabolism in 3T3-L1 and HepG2 cells are investigated. Lipid accumulation was reduced to a similar extent after treatment with both test substances during the maturation of 3T3-L1 cells by up to 6.91% for capsaicin and up to 4.89% for nonivamide (p < 0.01) at a concentration of 0.1μM or 1μM, resp. Energy-producing pathways, as indicated by the reduced mitochondrial oxygen consumption and reduced glucose and fatty acid uptake, were diminished after incubation with both capsaicinoids at a concentration of 100μM. The results from HPLC analyses revealed a reduced cellular energy charge potential after a 4 h treatment with nonivamide. In HepG2 cells, similar effects were demonstrated: the glucose uptake was reduced by 18.7% and 25.8% (p < 0.05), after a 24 h incubation with 100μM capsaicin and nonivamide, resp. In addition, the fatty acid uptake and oxygen consumption were decreased and the energy charge potential was diminished. These findings provide evidence that concentrations of capsaicin and nonivamide between 0.1 and 100μM modulate the mechanisms of cellular energy metabolism to a similar extent, independent of the investigated tissue. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Safety of N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 2444-46-4《Exhaled breath condensate methods adapted from human studies using longitudinal metabolomics for predicting early health alterations in dolphins》 was published in 2017. The authors were Borras, Eva;Aksenov, Alexander A.;Baird, Mark;Novick, Brittany;Schivo, Michael;Zamuruyev, Konstantin O.;Pasamontes, Alberto;Parry, Celeste;Foutouhi, Soraya;Venn-Watson, Stephanie;Weimer, Bart C.;Davis, Cristina E., and the article was included in《Analytical and Bioanalytical Chemistry》. The author mentioned the following in the article:

Monitoring health conditions is essential to detect early asymptomatic stages of a disease. To achieve this, blood, urine and breath samples are commonly used as a routine clin. diagnostic. These samples offer the opportunity to detect specific metabolites related to diseases and provide a better understanding of their development. Although blood samples are commonly used routinely to monitor health, the implementation of a relatively noninvasive technique, such as exhaled breath condensate (EBC) anal., may further benefit the well-being of both humans and other animals. EBC anal. can be used to track possible phys. or biochem. alterations caused by common diseases of the bottlenose dolphin (Tursiops truncatus), such as infections or inflammatory-mediated processes. The authors used an untargeted metabolomic method with liquid chromatog.-mass spectrometry anal. of EBC samples to determine biomarkers related to disease development. Five dolphins under human care were followed up for 1 yr. The authors collected paired blood, phys. examination information, and EBC samples. The authors then statistically correlated this information to predict specific health alterations. Three dolphins provided promising case study information about biomarkers related to cutaneous infections, respiratory infections, dental disease, or hormonal changes (pregnancy). The use of complementary liquid chromatog. platforms, with hydrophilic interaction chromatog. and reverse-phased columns, allowed the authors to detect a wide spectrum of EBC biomarker compounds that could be related to these health alterations. Moreover, these two anal. techniques not only provided complementary metabolite information but in both cases they also provided promising diagnostic information for these health conditions. [Figure not available: see fulltext.].N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Recommanded Product: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gutierrez-Villagomez, Juan Manuel;Ramirez-Chavez, Enrique;Molina-Torres, Jorge;Vazquez-Martinez, Juan published 《From Natural to Synthetic Quorum Sensing Active Compounds: Insights to Develop Specific Quorum Sensing Modulators for Microbe-Plant Interaction》 in 2020. The article was appeared in 《ACS Symposium Series》. They have made some progress in their research.Computed Properties of C17H27NO3 The article mentions the following:

It is clear the importance of plant-microbe interactions to accomplish food safety and sustainable agriculture. Many plant-microbe interactions depend on bacterial quorum sensing (QS) systems, so the manipulation of these communication systems could be a powerful instrument to modulate plant development. The search of compounds with the capacity to modulate the microbial communication systems using docking mol. anal. methods along with chromatog. and miniaturized microbiol. techniques offers a robust tool-kit for designing and testing quorum quenching (QQ) active compounds Further, the synthesis of QQ compounds can be achieved by applying enzymic processes with the advantages of lowering costs and generating fewer byproducts. To exemplify these processes, herein, a group of natural compounds known as alkamides and piperamides were tested using mol. docking simulations to detect QQ active compounds against the CviR and LasR QS receptors of Gram-neg. bacteria. The docking results show that some alkamides and piperamides bind specifically to each of the studied QS receptors. The structural anal. of the resp. crystalized-receptor native ligand and the best-docked alkamide/piperamide was used to design acyl amide-like compounds These new acyl amide-like compounds bind more efficiently to the studied QS receptors than the native ligands, according to the docking results. The designed compounds could also potentially modulate plant-microbe interactions related to cellular processes dependent on bacterial QS. The data we describe contributes to the understanding of plant-microbe interactions and investigates methods to modulate plant-microbe interactions that can impact sustainable food production The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Computed Properties of C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rosas, Julieta;Martinez, Joel O.;Alonso, Pedro;Miranda, Rene;Velasco, Luis;Rubio-Perez, Laura;Perez, Francisco J. published 《Alternative mass spectrometry techniques for the validation of the fragmentation pattern of capsaicin and dihydrocapsaicin》. The research results were published in《Rapid Communications in Mass Spectrometry》 in 2019.Recommanded Product: N-Vanillylnonanamide The article conveys some information:

Rationale : Capsaicinoids are prevalent secondary metabolites in many natural and synthetic pharmacol. compounds To date, several soft ionization studies related to capsaicinoids have been reported; they all proposed a common fragmentation pattern based on a rearrangement of the aromatic double bonds and the fragmentation of the various positional acyl chains. However, the mechanism has never been validated by high-resolution analyses. Consequently, in this work, a validated fragmentation mechanism of the main capsaicinoids, capsaicin (1) and dihydrocapsaicin (2), is offered. Methods : In order to propose and validate a common electron ionization (EI) fragmentation mechanism for the target analytes, the following mass spectrometric methods were employed: collision-induced dissociation (CID) by means of linked scans (LS), reinforcing the methodol. by high-resolution mass spectrometry (HRMS), in addition to appropriate deuterium-labeled experiments performed using gas chromatog./mass spectrometry (GC/MS) and direct anal. in real time (DART). Results : In a first stage, a common EI fragmentation pattern comprising two pathways was proposed for compounds 1 and 2; then, the suggested mechanism was validated by CID-LS together with HRMS complemented by DART-deuterium-labeling studies. The obtained results are indicative that the corresponding mol. ions were conveniently observed, m/z 305 and m/z 307; it is worth noting that the common base peak is in correspondence with a tropylium ion derivative (m/z 137), as a consequence of a McLafferty rearrangement. In addition to these highlighted fragments, other common ions, m/z 122 and m/z 94, and their corresponding trajectory, were confirmed using the same approach. Finally, the proposed mechanism was complementarily validated by deuterium-labeling studies, taking into account the two exchangeable hydrogens present in the phenolic and the amidic moieties. Conclusions : A common validated EI fragmentation pattern for both capsaicin and dihydrocapsaicin was established using appropriated mass spectrometric methods together with convenient hydrogen/deuterium labeling. This study provides a new alternative to validate mechanisms of fragmentation of important natural products. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Recommanded Product: N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics