Category: 2444-46-4

Stoeger, Verena;Lieder, Barbara;Riedel, Johanna;Schweiger, Kerstin;Hoi, Julia;Ruzsanyi, Veronika;Klieber, Martin;Rust, Petra;Hans, Joachim;Ley, Jakob P.;Krammer, Gerhard E.;Somoza, Veronika published 《Wheat Protein Hydrolysate Fortified With L-Arginine Enhances Satiation Induced by the Capsaicinoid Nonivamide in Moderately Overweight Male Subjects》 in 2019. The article was appeared in 《Molecular Nutrition & Food Research》. They have made some progress in their research.Application of 2444-46-4 The article mentions the following:

Increasing the intake of satiety-enhancing food compounds represents a promising strategy for maintaining a healthy body weight Recently, satiating effects for the capsaicinoid nonivamide have been demonstrated. As various proteins and amino acids have also been demonstrated to decrease energy intake, oral glucose tolerance test (oGTT)-based bolus interventions of 75 g glucose + 0.15 mg nonivamide (NV control) are tested with/without combination of a wheat protein hydrolyzate (WPH: 2 g) and/or L-arginine (ARG: 3.2 g) for their satiating effects in 27 moderately overweight male subjects. Compared to NV control intervention, ARG and WPH + ARG treatment both reduce (p < 0.01) total calorie intake from a standardized breakfast by -5.9 ± 4.15% and -6.07 ± 4.38%, resp. For the WPH + ARG intervention, increased mean plasma serotonin concentrations (AUC: 350 ± 218), quantitated by ELISA, and delayed gastric emptying, assessed by ¹³C-Na-acetate breath test (-2.10 ± 0.51%, p < 0.05), are demonstrated compared to NV control. Correlation anal. between plasma serotonin and gastric emptying reveals a significant association after WPH ± ARG intervention (r = -0.396, p = 0.045). Combination of WPH and ARG enhances the satiating effect of nonivamide, providing opportunities to optimize satiating food formulations by low amounts of the individual food constituents. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Application of 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 2444-46-4《Voltammetric determination of capsaicin using CeO₂-surfactant/SWNT-modified electrode》 was published in 2020. The authors were Ziyatdinova, Guzel;Ziganshina, Endzhe;Shamsevalieva, Aliya;Budnikov, Herman, and the article was included in《Arabian Journal of Chemistry》. The author mentioned the following in the article:

Glassy carbon electrodes (GCE) modified with carboxylated single-walled carbon nanotubes (SWNT-COOH) and CeO₂-surfactants dispersions are developed for the capsaicin quantification. The effect of cationic cetylpyridinium bromide (CPB), anionic sodium dodecylsulfate (SDS) and nonionic Triton X100 as co-modifiers are tested. CeO₂-CPB/SWNT-COOH/GCE provides 2.8- and 1.9-fold increase of capsaicin oxidation currents in comparison to bare GCE and SWNT-COOH/GCE, resp., confirming the synergetic effect of the modifiers. SEM (SEM) data confirm successful immobilization of the nanomaterials on the electrode surface leading to the significant changes in its morphol. The parameters of capsaicin electrooxidation are found. Differential pulse mode is applied for the capsaicin determination The pulse parameters are optimized. The linear dynamic ranges of 0.10-7.5 and 7.5-500μM of capsaicin with the limits of detection and quantification of 28 and 92 nM resp. confirm the high sensitivity of the method developed. The selectivity of the electrode toward capsaicinoids is proved. The method was applied for the total capsaicinoids quantification in real samples (red hot pepper spices and tinctures of Capsicum annuum L.). A good agreement with the UV-spectroscopic data is obtained.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.SDS of cas: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C17H27NO3《Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking》 was published in 2022. The authors were He, Yue;Zhang, Xiaoyin;Li, Ming;Zheng, Nan;Zhao, Shengguo;Wang, Jiaqi, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

Inhibition of ruminal bacterial urease activity could slow down the decomposition of urea to ammonia, which would lead to a decrease in urea synthesis in the liver and urea-N emission in the urine. In order to find a rumen bacterial urease specific inhibitor that is environmentally friendly, we used the homol. model of rumen bacterial urease as the target to screen natural compounds from plants by mol. docking. The screening results showed that coptisine had the most potential to inhibit the activity of rumen bacterial urease with an IC50 of 2.45μM, which was superior to the traditional inhibitor acetohydroxamic acid. The enzyme kinetics results indicated coptisine was mixed type inhibitor of rumen bacterial urease with a Ki value of 0.68μM. Coptisine significantly decreased the release of NH3 and decomposition of urea and improved microbial fermentation in a rumen fermentation system in vitro. Thiol-containing compounds or boric acid significantly decreased the inhibitory capacity of coptisine toward rumen bacterial urease, which indicated that coptisine could interact with both the urease active center Ni and amino acid residues possessing sulfhydryl groups in the flap area. The mol. docking results showed that coptisine acted as the metal acceptor for one nickel ion in the active site, and formed hydrogen bonds with the amino acid residues His320 and His362, which were located in the active site and flap region, resp. These findings emphasized the potential role of coptisine in reducing nitrogen emissions that originate from ruminants by regulating rumen bacterial urease activity. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.COA of Formula: C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guo, Zhen;Li, Xiu-qin;Gao, Fang-yuan;Zhang, Qing-he;Li, Hong-mei published 《Determination of capsaicinoids in edible oil by liquid chromatography-isotope dilution mass spectrometry》. The research results were published in《Huaxue Shiji》 in 2016.Name: N-Vanillylnonanamide The article conveys some information:

A method was developed on determination of capsaicinoids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin and n-vanillvlnonanamide) in edible oil by liquid chromatog.-isotope dilution mass spectrometry (LC-IDMS). The sample was firstly extracted with sodium hydroxide solution, and then the extract was cleaned-up by auto solid phase extraction (SPE) before the LC-IDMS anal. The limit of detection (LOD, S/N>3) for capsaicinoids was 0.015 μg/kg, and the recoveries of the 4 kinds of capsaicinoids in edible oil samples were 96.2%-105% with the RSDs ranging 0.5%-3.8% (n = 6). Edible oils and illegal edible oils were both analyzed using this method, and significant differences were observed The results showed that there were no capsaicinoids in most kinds of edible oils. Peanut oil contained little capsaicinoids ranging 0-1.8 μg/kg which might come from peanut. The content of capsaicinoids was above 600 μg/kg in most illegal cooking oils. This method can be used as one of identification methods on illegal cooking oil. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Name: N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Qian;Yao, Li;Qin, Panzhu;Xu, Jianguo;Sun, Xun;Yao, Bangben;Ren, Fei;Chen, Wei published 《Time-resolved fluorescent lateral flow strip for easy and rapid quality control of edible oil》 in 2021. The article was appeared in 《Food Chemistry》. They have made some progress in their research.Name: N-Vanillylnonanamide The article mentions the following:

Gutter oil is strictly prohibited from being reprocessed back to the catering and food industry. Extensive attention has been paid to rapid screening of gutter oil to guarantee the safety of edible oil. Capsaicin, a special component of condiments, has been adopted as the marker of gutter oil. The time-resolved fluorescent microspheres are utilized for labeling of antibody to capsaicin, which are further applied for the construction of fluorescent lateral-flow-strip (LFS). By simple extraction of capsaicin with ethanol (or liquor) from the edible oil, the capsaicin can be rapid determined with the fluorescent LFS in less than 10 min. As low as 20 ng/mL capsaicin can be visually judged and 2.3 ng/mL is achieved as the detection limit by ImageJ anal. The illegal gutter oil is also well screened with this time-resolved LFS. This method can be a useful candidate for routine quality monitoring of edible oil and a powerful tool for self-inspection at home.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Name: N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Borusiewicz, Rafal;Martyna, Agnieszka;Zadora, Grzegorz;Zahrebelna, Anastasiia published 《Differentiation of oleoresin capsicum sprays based on their capsaicinoid profiles》 in 2021. The article was appeared in 《Forensic Science International》. They have made some progress in their research.Electric Literature of C17H27NO3 The article mentions the following:

Oleoresin capsicum (OC) sprays, often referred to as pepper sprays, contain a solution of active compounds, exerting an irritating effect on the human body. The active component of OC sprays are capsaicinoids, obtained by extraction from peppers. The profiles (quant. relations) of natural capsaicinoids depend on the plant material, they were extracted from. Pepper spray is a non-lethal weapon that should only be used for self-defense but is often used by criminals to attack and incapacitate victims. Evidence related to these types of incidents, such as containers, clothes of victims or suspects, as well as traces of substances found at the scene, are submitted to the forensic laboratory The purpose of the anal. is to identify the ingredients of the preparation (especially active components) and compare the traces found on objects from the victim or the scene of the incident with the preparation from the can or traces found on objects related to the suspect. The study aimed to investigate the possibility of differentiating OC gases based on capsaicinoid profiles recorded in GC-MS analyses. Sixty-four gases from 12 different manufacturers were purchased and tested. The likelihood ratio (LR) approach was applied to the data expressing the relative capsaicinoids contents computed by integrating GC-MS signals. Two hypotheses were assumed that stated either common or different origins of the samples. Several LR models have been developed, and their performance has been controlled by the number of false positives and false negatives as well as empirical cross entropy. The research results showed that differentiation was very successful, with more than 90% of correct responses. The results obtained show that OC sprays may be distinguished, even if they were produced by the same producer presumably if produced using different batches of pepper extract To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Electric Literature of C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Satpute, Ravindra M.;Kushwaha, Pramod K.;Nagar, D. P.;Rao, P. V. L. published 《Comparative safety evaluation of riot control agents of synthetic and natural origin》 in 2018. The article was appeared in 《Inhalation Toxicology》. They have made some progress in their research.Application In Synthesis of N-Vanillylnonanamide The article mentions the following:

Riot control agents (RCA) are lachrymatory, irritating compounds which temporarily incapacitate the uncontainable crowd. Ortho-Chlorobenzylidene-malononitrile (CS), 2-chloroacetophenone (CN), dibenz[b,f]1:4-oxazepine (CR), and nonivamide (PAVA) are synthetic RCAs, while oleoresin extract of chili known as oleoresin capsicum (OC) a natural irritant has been in use by various law enforcement agencies. Though efficacy of these agents is beyond doubt, they suffer from certain drawbacks including toxicity, production cost, and ecol. compatibility. Presently, we have evaluated the safety of CR, OC, and PAVA on inhalation variables along with oral lethality. Addnl., the liver function test (LFT) in serum and lungs function was evaluated in broncho-alveolar-lavage fluid (BALF), both collected on the 14th day after RCA exposure. Animals then sacrificed and histopathol. of liver and lungs was carried out. Results showed OC and PAVA to be more toxic than CR with an oral LD₅₀ of 150 and 200 mg/kg body weight, resp., while CR was safe at >3 g/kg body weight All three agents caused severe impairment of respiratory variables bringing down normal respiration by >80% with rise in sensory irritation. Recovery from the irritating effect of CR was more rapid than OC and PAVA. LFT and BALF variables were not significantly different from that of control. There were no remarkable histopathol. changes in liver and lungs. Hence, as per results, CR is safest among all synthetic and natural origin RCAs and can be safely used for effective dispersion of disobedient mob. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Application In Synthesis of N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palo-Nieto, Carlos;Afewerki, Samson;Anderson, Mattias;Tai, Cheuk-Wai;Berglund, Per;Cordova, Armando published 《Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis》. The research results were published in《ACS Catalysis》 in 2016.Recommanded Product: 2444-46-4 The article conveys some information:

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymic multiple relay catalysis for eco-friendly and asym. synthesis of valuable mols. (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biol. and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcs., resp.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Recommanded Product: 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kaiser, Mathias;Chalapala, Sudharani;Gorzelanny, Christian;Perali, Ramu Sridhar;Goycoolea, Francisco Martin published 《The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells》 in 2016. The article was appeared in 《Journal of Pharmaceutical Sciences》. They have made some progress in their research.Formula: C17H27NO3 The article mentions the following:

Capsaicin is known to interfere with tight junctions (TJs) of epithelial cells and therefore to enhance paracellular permeability of poorly absorbable drugs. However, due to its low water solubility, pungency, and cytotoxicity, its pharmacol. use is limited. In this study, the authors investigated the effect of capsaicin derivatives of synthetic (e.g., 10-hydroxy-N-(4-hydroxy-3-methoxybenzyl)decanamide, etc.) and natural (olvanil and dihydrocapsaicin) origin on Madin-Darby Canine Kidney-C7 cells. Impedance spectroscopy was used to determine the transepithelial elec. resistance and the capacitance. Permeability assays with fluorescein isothiocyanate-dextran were carried out to evaluate the impact on cell permeability. The results show that lipophilicity could play an important role for the interference with TJ and that the mechanism is independent from the ion channel TRPV-1 and hence on the flux of calcium into the cells. In summary, the authors synthesized 4 derivatives of capsaicin of lower lipophilicity and compared their properties with other well-known vanilloids. The authors show that these compounds are able to enhance the permeability of a hydrophilic macromol., by opening the TJ for a shorter time than capsaicin. This behavior is dependent on the lipophilicity of the mol. Understanding of these phenomena may lead to better control of administration of therapeutic mols. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Formula: C17H27NO3 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Chuan;Ma, Dianping;Cao, Wenming;Shi, Haiming;Jiang, Yuanrong published 《Fast simultaneous determination of capsaicin, dihydrocapsaicin and nonivamide for detecting adulteration in edible and crude vegetable oils by UPLC-MS/MS》 in 2018. The article was appeared in 《Food Additives & Contaminants, Part A》. They have made some progress in their research.Safety of N-Vanillylnonanamide The article mentions the following:

Capsaicinoids are pungent components in hot peppers, which have been detected in waste cooking oil. However, trace anal. of capsaicinoids in edible and crude vegetable oils is a challenging task due to the complex matrix. In this study, a simple liquid-liquid extraction and solid phase extraction (SPE) coupled with RP-UPLC-ESI-MS/MS method was developed for the quantification of capsaicinoids in edible and crude vegetable oils to screen the adulteration with waste cooking oil. This method was used to simultaneously determine 3 capsaicinoids (capsaicin, dihydrocapsaicin, and nordihydrocapsaicin) with capsaicin-d₃, and dihydrocapsaicin-d₃ as internal standards This method allows the complete anal. of a sample in only an hour, even including sample preparation and chromatog. separation The linear range of 3 capsaicinoids ranged between 0.5 and 40 μg/kg. The limit of detection (LOD) and limit of quantification (LOQ) for capsaicinoids were calculated as 0.15 and 0.5 μg/kg, resp. Quant. recoveries ranging from 92.9% to 105% were obtained by the anal. of spiked oil. The relative standard deviations were less than 5% (n = 6). The established method can potentially overcome the interference of triacylglycerols and fatty acids in edible and crude vegetable oils, and have been successfully applied to analyze real oil samples. This method provided a rapid and reliable method for the detection of adulteration of vegetable oils with waste cooking oils.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Safety of N-Vanillylnonanamide It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics