Category: 24243-71-8

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24243-71-8 as follows. COA of Formula: C3H9NO2S

In DMSO were dissolved 2,3-dichloroquinoxaline (5.00 g, 25.1 mmol) and propane-1-sulfonamide (3.09 g, 25.1mmol). Potassium carbonate (3.47 g, 25.1 mmol) was added and the mixture was stirred at 150C for 1 hour. A 1%aqueous acetic acid solution was added to the mixture and the mixture was stirred at room temperature for 3 hours. Theprecipitated solid was separated by filtration and the obtained solid was washed with water. The separated solid wasthen purified by slurrying in diisopropyl ether to give compound AA (6.01 g, 84% yield).

According to the analysis of related databases, 24243-71-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; KANAI, Toshimi; UCHIDA, Kenji; HONMA, Masakazu; FUKUDA, Yuichi; (51 pag.)EP2781517; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 24243-71-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24243-71-8, name is Propane-1-sulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

To a 100-mL rm.md-hottom flask ‘.Vas added 2-[(1S,4S,5R)-5-[[5-cydopropyl-3-(2,6-dichorophenyl)-1 ,2-oxazol-4-yl]carbonyloxy ]-2-azahicyclol2.2.l]heptan-2-yl]-4-fluoro-l,3-benzothiazole-6-carboxylic acid I-1 (150 mg, 0.25 mmol, 1.0 equiv), dichloromethane (15mL), propane-1-sulfonamide (47 mg, 0.38 mmol, 1.5 equiv.), 4-dimethylaminopyridine (4715 mg, 0.38 mmoL 1.5 equiv), and EDC1 (73 mg, 0.38 mmol, 1.5 equiv) and the resultingmixture was stirred at room temperature for 16 h. 1 00 mL of brine was added and theaqueous mixture was extracted w·ith dichloromethane (l 00 mL x .5). The combined organicextracts ‘.vere dried over anhydrous sodium sulfate, filtered, and concentrated under reducedpressure. The residue was dissolved in 2 mL ofDMF and purified by Prep-HPLC using the20 follo·wing conditions: Column, XBridge C18 OBD Prep Column, 19 mm x 250 rnm; mobilephase, water (0 05% TFA) and ACN (68% to 84% over 8 min): Detector, UV 254 nm, toprovide 48.9 mg (28%) of(lS,4S,5R)-2-[4-fluoro-6-l(propane-l-sulfonyl)carbamoyl]-1,3-benzothiazol-2-y l]-2-azabicydo[2.2.1]heptan-5-y 5-cy dopropy l-3-(2,6-dichlorophenyl)-1 ,2-oxazole-4-carboxylate l-32 as a white solid. 1H NMR (300 MHz, CD30D) 8: 8.08 (d, J = 1.72.5 Hz, 1H), 7.70 — 7.49 (m, 4H), 5.00 (d, J ··· 6.6 Hz, lH), 4.41 (s, lH), 3.62—3.47 (m, 3H),3.23 (s, 1H), 3.00 (p, J 6.7 Hz, 1H), 2.60 (s, 1H), 2.25 (ddd, J 14. L 7.1, 2.5 Hz, lH),199- 1.78 (m, 2H), 1.71 (d, J = 10.6 Hz, HI), l.41- l.28 (m, 6H), 1.10 (t J = 7.5 Hz, 3H). MS (ES, m/z): [M+1l ” 693.25.

The chemical industry reduces the impact on the environment during synthesis Propane-1-sulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 24243-71-8, name is Propane-1-sulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C3H9NO2S

A mixture of 5-(6-chloro-2-phenylpyrimidin-4-yl)-1,3-dimethylpyridin-2(1H)-one (51 mg, 0.2 mmol), propane-1-sulfonamide (37 mg, 0.3mmo1), Pd(dba)3 (18 mg, 0.02 mmol), Xphos (9 mg, 0.2 mmol), CsCO3 (130 mg, 0.4 mmol) in dioxane (3 mL) was stirred and heated at 90 C. for 16 hr. The reaction mixture was diluted with water and extracted with EtOAc (3*). The extracts were combined, washed with brine, dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (EA:Hex, 0-100%) to provide the 16 mg (23%) of the desired product as an off-white solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 0.99 (t, J=7.45 Hz, 3H) 1.78 (sxt, J=7.38 Hz, 2H) 2.14 (s, 3H) 3.32 (s, 3H) 3.62 (s, 3H) 3.63-3.69 (m, 2H) 7.06 (s, 1H) 7.51-7.59 (m, 3H) 7.99 (s, 1H) 8.41-8.52 (m, 2H) 8.64 (d, J=2.27 Hz, 1H) 11.26 (br. s., 1H).

The synthetic route of Propane-1-sulfonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CELGENE QUANTICEL RESEARCH, INC.; Bennett, Michael John; Betancort, Juan Manuel; Boloor, Amogh; Kanouni, Toufike; Stafford, Jeffrey Alan; Veal, James Marvin; Wallace, Michael Brennan; (250 pag.)US2017/298040; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 24243-71-8, A common heterocyclic compound, 24243-71-8, name is Propane-1-sulfonamide, molecular formula is C3H9NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0171] NaH (60% in mineral oil, 80 mg, 1.99 mmol) was slowly added to a solution of propane-i-sulfonamide (226 mg, 1.84 mmol) in DMF (20.0 mL) at 0 C. The reaction mixture was degassed with N2 and stirred at room temperature for 60 mm. Then 9-(3-fluoro- 2-nitrophenoxy)-2,3-dihydroimidazo[i,2-cjquinazoline (500 mg, 1.53 mmol) was added and the mixture was stirred at 80 C overnight under N2. The resulting mixture was evaporated and the residue was purified by flash column (ACN/H20) to afford N-(3-((2,3- dihydroimidazo [1 ,2-cjquinazolin-9-yl)oxy)-2-nitrophenyl)propane- i-sulfonamide (240 mg, 37% yield) as a yellow solid. ?H NMR (400 MHz, DMSO-d6): 8.24 (s, 1H), 7.67 (d, J = 8.8 Hz, 1H), 7.57-7.51 (m, 2H), 7.39-7.32 (m, 2H), 6.68 (d, J= 7.2 Hz, 1H), 4.34 (t, J= 10.0 Hz, 2H), 4.00 (t, J= 10.0 Hz, 2H), 2.96 (t, J= 7.6 Hz, 2H), 1.72-1.66 (m, 2H), 0.96 (t, J= 7.6 Hz, 3H). LCMS (M+H) mlz: 430.1.

The synthetic route of 24243-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABM THERAPEUTICS, INC.; CHEN, Chen; (154 pag.)WO2019/60611; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 24243-71-8, name is Propane-1-sulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Propane-1-sulfonamide

General procedure: Standard Procedure C for the Preparation of Thiazolidinyl Sulfonamides (0053) To a solution of 4-[2-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-3-yl]-3-methylbenzoic acid in CH2Cl2 was added 4-(dimethylamino)pyridine (DMAP), sulfonamide, and N-ethyl-N?-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI ? HCl) at room temperature. After the reaction mixture was stirred for 16 h-20 h, it was diluted with CH2Cl2 and washed with 2 N HCl(aq) and brine. The organic layer was dried over MgSO4(s), filtered, and concentrated. The residue was purified to give the desired products. Step 2. 4-[2-(4-Fluorophenyl)-4-oxo-1, 3-thiazolidin-3-yl]-3-methyl-N-(propylsulfonyl)benzamide Following standard procedure C, 4-[2-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-3-yl]-3-methylbenzoic acid (71.2 mg, 0.215 mmol), DMAP (65.7 mg, 0.538 mmol), EDCI ¡¤ HCl (82.4 mg, 0.430 mmol), 1-propanesulfonamide (35.4 mg, 0.258 mmol), and CH2Cl2 (4.0 mL) were used to carry out the reaction. After the reaction was stirred for 18 h and work-up, the residue was purified by column chromatography (5% MeOH in CH2Cl2) to give 4-[2-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-3-yl]-3-methyl-N-(propylsulfonyl)-benzamide (54.8 mg, 58%) as a beige solid. 1H NMR (CDCl3, 300 MHz) delta 9.01 (br s, 1H), 7.61-7.45 (br, 2H), 7.33-7.28 (m, 2H), 6.95 (br t, 2H), 5.97 (br s, 1H), 4.00 (s, 2H), 3.49-3.44 (m, 2H), 2.17 (br s, 3H), 1.86 (sextet, 2H), 1.09 (t, 3H); LC-MS (ESI) m/z 437.2 [M+H]+.

The synthetic route of Propane-1-sulfonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; National Health Research Institutes; Ueng, Shau-Hua; Yeh, Shiu-Hwa; Lin, Shu-Yu; Shih, Chuan; (329 pag.)US2017/253569; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24243-71-8 as follows. Computed Properties of C3H9NO2S

EXAMPLE 14 (+-)-trans-N-(6-Butoxy-3-hydroxy-2,2-dimethylchroman-4-yl)-N-ethyl-methanesulfonamide STR29 The compound was obtained from 6-butoxy-2,2-dimethyl-3,4-epoxychroman (Example 5d) and ethyl-methanesulfonamide similarly to Example 5e. After silica gel chromatography using methylene chloride/methanol 97:3, the title compound of a melting point of 139-140 C. was isolated.

According to the analysis of related databases, 24243-71-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoechst Marion Roussel Deutschland GmbH; US6008245; (1999); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 24243-71-8, name is Propane-1-sulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24243-71-8, Quality Control of Propane-1-sulfonamide

Example 119 1-(2-Chlorobenzyl)-2-Methyl-6-(2-Propanesulfonylcarbamoyl) Benzimidazole By using the method of example 111, 1-(2-chlorobenzyl)-2-methyl-6-(2-propanesulfonylcarbamoyl)benzimidazole (0.417 g) is obtained from 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (0.400 g) (example 75), N,N’-carbonyldiimidazole (0.431 g), 1-propanesulfonamide (0.328 g) and diazabicycloundecene (0.404 g). 1H-NMR (DMSO-d6, delta): 1.30 (6H, d, J=6.9 Hz), 2.50 (3H, s), 3.81-3.87 (1H, m), 5.62 (2H, s), 6.46 (1H, d, J=7.7 Hz), 7.25 (1H, t, J=7.5Hz), 7.35 (1H, t, J=7.5 Hz), 7.62 (1H, d, J=7.9 Hz), 7.69 (1H, d, J=8.5 Hz), 7.81 (1H, d, J=8.6 Hz), 8.12 (1H, s), 11.8 (1H, s). IR(KBr): 1670 cm-1. mp: 215.0-217.5 C. (R1=2-chlorobenzyl, R7=methyl, R3=-C(O)NR4R5, R4=SO2R6, R5=H, R6=propyl, n=1, y=0)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Cell Pathways, Inc.; US6348032; (2002); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

24243-71-8, Adding some certain compound to certain chemical reactions, such as: 24243-71-8, name is Propane-1-sulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24243-71-8.

A mixture of 2′-chloro-6′-(2,6-dimethylphenoxy)-1,5-dimethyl43,4′-bipyridin]-6(1H)-one (52 mg, 0.15 mmol), propane-1-sulfonamide (46 mg, 0.37 mmol), Pd2(dba)3 (7 mg, 5%), X-Phos (11 mg, 15%) and Cs2CO3 (68 mg, 0.21 mmol) was diluted with 1,4 dioxane (1 mL). After the mixture was purged with nitrogen for 5 min, it was sealed and heated to 90 C. for 3 hr. The cooled mixture was poured into H2O and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by prep-HPLC (10 min_10-95% ACN_0.1% formic acid, 20 ml/min) to afford the title compound (36 mg, 55%) as a tan solid. 1H NMR (400 MHz, DMSO-d6) delta 0.69-0.76 (m, 3H) 1.32-1.43 (m, 2H) 2.03-2.12 (m, 9H) 2.62-2.71 (m, 2H) 3.54 (s, 3H) 6.62 (s, 1H) 6.98 (s, 1H) 7.03-7.15 (m, 3H) 7.72 (s, 1H) 8.22 (s, 1H) 10.36 (br s, 1H). LCMS (M+H)+442.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24243-71-8.

Reference:
Patent; CELGENE QUANTICEL RESEARCH, INC.; Bennett, Michael John; Betancort, Juan Manuel; Boloor, Amogh; Kanouni, Toufike; Stafford, Jeffrey Alan; Veal, James Marvin; Wallace, Michael Brennan; (250 pag.)US2017/298040; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics