Category: 24167-56-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24167-56-4, name is 4-Fluoro-N,N-dimethylbenzamide, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 24167-56-4

General procedure: Oxalyl chloride (1.0 equiv) was added dropwise at r.t. (except in synthesis of 4e, where addition was at 0 C) to the corresponding N,N-dialkylbenzamide 1 (1.0 equiv) in anhydrous CH2Cl2 (1.0 mL/mmol 1) under N2 atmosphere. The reaction mixture was heated at 35 C for 5 h. Generally, a white solid was observed after few minutes. When the reaction was finished, anhydrous CH2Cl2 was added (4.0 mL/mmol 1) at 0 C; usually at this temperature the solid dissolved. A solution of trichloroacetamidine 2 (1.0 equiv) in anhydrous CH2Cl2 (1.0 mL/mmol 2) was added dropwise at 0 C. Immediately a white suspension formed, and the reaction mixture was stirred overnight at r.t. Finally, DIPEA (2.2 equiv) was added at 0 C; a pale yellow solution resulted. CH2Cl2 (20 mL) was added and the organic phase was washed with saturated NaCl solution, dried over Na2SO4, and concentrated in vacuo. The resulting crude 1,3-diazabutadiene 4 was obtained in quantitative yield, usually contaminated with small quantities of starting material as an oil that slowly crystallized. The 1,3-diazadienes 4 were purified by flash column chromatography (silica gel, hexanes-EtOAc). After purification, 1,3-diazadienes 4 were obtained as crystals or as oils.

According to the analysis of related databases, 24167-56-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Seballos-Resendiz, Arturo; Lechuga-Eduardo, Harim; Barroso-Flores, Joaquin; Martinez-Otero, Diego; Romero-Ortega, Moises; Synthesis; vol. 48; 14; (2016); p. 2205 – 2212;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24167-56-4, name is 4-Fluoro-N,N-dimethylbenzamide, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Fluoro-N,N-dimethylbenzamide

General procedure: Oxalyl chloride (1.0 equiv) was added dropwise at r.t. (except in synthesis of 4e, where addition was at 0 C) to the corresponding N,N-dialkylbenzamide 1 (1.0 equiv) in anhydrous CH2Cl2 (1.0 mL/mmol 1) under N2 atmosphere. The reaction mixture was heated at 35 C for 5 h. Generally, a white solid was observed after few minutes. When the reaction was finished, anhydrous CH2Cl2 was added (4.0 mL/mmol 1) at 0 C; usually at this temperature the solid dissolved. A solution of trichloroacetamidine 2 (1.0 equiv) in anhydrous CH2Cl2 (1.0 mL/mmol 2) was added dropwise at 0 C. Immediately a white suspension formed, and the reaction mixture was stirred overnight at r.t. Finally, DIPEA (2.2 equiv) was added at 0 C; a pale yellow solution resulted. CH2Cl2 (20 mL) was added and the organic phase was washed with saturated NaCl solution, dried over Na2SO4, and concentrated in vacuo. The resulting crude 1,3-diazabutadiene 4 was obtained in quantitative yield, usually contaminated with small quantities of starting material as an oil that slowly crystallized. The 1,3-diazadienes 4 were purified by flash column chromatography (silica gel, hexanes-EtOAc). After purification, 1,3-diazadienes 4 were obtained as crystals or as oils.

According to the analysis of related databases, 24167-56-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Seballos-Resendiz, Arturo; Lechuga-Eduardo, Harim; Barroso-Flores, Joaquin; Martinez-Otero, Diego; Romero-Ortega, Moises; Synthesis; vol. 48; 14; (2016); p. 2205 – 2212;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24167-56-4, name is 4-Fluoro-N,N-dimethylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 4-Fluoro-N,N-dimethylbenzamide

EXAMPLE 7 A solution of 758 mg. of N,N-dimethyl-4-fluorobenzamide and 0.44 ml. of phosphorous oxychloride in 50 ml. of 1,2-dichloroethane is refluxed for one hour. To this solution is added a solution of 500 mg. of isopropyl 5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate in 10 ml. 1,2-dichloroethane. The reaction mixture is refluxed for 3 hours. A solution of 3.3 g. sodium acetate trihydrate in 9 ml water is added and refluxed for a further 10 hours. The organic phase is separated, washed with saturated sodium chloride solution, dried over sodium sulfate and evaporated to dryness. The residue is purified by preparative t.l.c. using hexane:ethyl acetate (90:10). Crystallization from dichloromethane-hexane yields isopropyl 3-p-fluorobenzoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate (XI, R=H, L=p-F, R2 =iC3 H7, n=1), m.p. 92 C.

The synthetic route of 24167-56-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Syntex (U.S.A.) Inc.; US4410534; (1983); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics