Category: 2387-23-7

Synthesis and Investigation of the Antidepressant Properties of Arginine-Vasopressin was written by Borodina, K. V.;Savanets, O. N.;Pustyulga, E. S.;Martinovich, V. P.;Kravchenko, E. V.;Olgomets, L. M.;Golubovich, V. P.. And the article was included in Russian Journal of Bioorganic Chemistry in 2022.Formula: C13H24N2O This article mentions the following:

A search for novel antidepressant analogs of arginine-vasopressin (AVP) by a computer modeling revealed the following peptide analogs of the C-terminal part of AVP: N-Ac-D-Ser-Pro-D-Arg-Gly-NH2, N-Ac-Phe-Pro-Arg-Gly-NH2, and N-Ac-Trp-Pro-Arg-Gly-NH2. Syntheses of the modeled compounds were described in this article. The compounds that could potentially exhibit the antidepressant activity were examined in the forced swimming test. N-Ac-Trp-Pro-Arg-Gly-NH2 (0.1, 1.0, and 10.0 μg/kg) and N-Ac-D-Ser-Pro-D-Arg-Gly-NH2 (1.0 μg/kg) were shown to have the highest similarity to the fluoxetine reference antidepressant according to a number of parameters after the intranasal administration to the Wistar male rats. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N,N’-Dicyclohexyl-N-(phthaloylglycyl)urea was written by Bernes, Sylvain;Hernandez-Linares, Maria Guadalupe. And the article was included in IUCrData in 2021.Computed Properties of C13H24N2O This article mentions the following:

The mol. structure of the title compound {systematic name: 1,3-dicyclohexyl-1-[2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetyl]urea}, C23H29N3O4, derived from N,N’-dicyclohexylurea, shows that the tertiary N atom substituted by a cyclohexyl and phthaloylglycyl groups adopts a perfectly planar geometry (bond-angle sum = 360.0°). In the same way as for N,N’-dicyclohexylurea, the extended structure of the title compound features N-H···O hydrogen bonds, which generate chains of mols. running in the [001] direction. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nonstrained γ-Butyrolactone to High-Molecular-Weight Poly(γ-butyrolactone): Facile Bulk Polymerization Using Economical Ureas/Alkoxides was written by Lin, Limiao;Han, Dongmei;Qin, Jiaxiang;Wang, Shuanjin;Xiao, Min;Sun, Luyi;Meng, Yuezhong. And the article was included in Macromolecules (Washington, DC, United States) in 2018.Recommanded Product: 1,3-Dicyclohexylurea This article mentions the following:

We disclose an efficient catalyst system of com. ureas/alkoxides for the challenging ring-opening polymerization (ROP) of bioderived “nonpolymerizable” γ-butyrolactone (γ-BL). This effective polymerization can not only be performed under mild conditions like bulk polymerization, higher monomer ratio, and elevated temperature (-20 °C comparing to -40 °C), but also obtains high-mol.-weight poly(γ-butyrolactone) (PγBL) (M_n up to 68.2 kg/mol). To our knowledge, this is a big progress in the research area of ROP of γ-BL, which provides a promising prospect for the industrial-scale methodol. of PγBL production Structural anal. including NMR and MALDI-TOF, along with mechanistic computational studies based on DFT calculations, show that urea anion acts as a bifunctional catalyst, which activates the alc. initiator and γ-BL before obeying an anionic polymerization Furthermore, the catalytic activities of ureas/alkoxides systems have been optimized using the ureas with electron-donating groups which are proved to have lower activation barrier by computational calculation In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Photo-on-Demand Phosgenation Reactions with Chloroform for Selective Syntheses of N-Substituted Ureas and Isocyanates was written by Muranaka, Ryo;Liu, Yue;Okada, Itsuumi;Okazoe, Takashi;Tsuda, Akihiko. And the article was included in ACS Omega in 2022.Quality Control of 1,3-Dicyclohexylurea This article mentions the following:

Two new reaction processes involving the in situ oxidative photochem. conversion of CHCl₃ to COCl₂ allowed selective syntheses of N-substituted ureas and isocyanates from amines. (I) A CHCl₃ solution containing an amine and an organic base under O₂ bubbling provided the urea derivative under exposure to UV light generated from a low-pressure mercury lamp at 20-40°C. (II) A two-step reaction involving the oxidative photodecomposition of CHCl₃ at lower temperatures and subsequent sequential injections of an amine and organic base into the sample solution provided the isocyanate in high yield. The reaction processes of (I) and (II) capitalize on the solution conditions of [COCl₂] < [amine] and [COCl₂] > [amine], resp., to result in 1:2 and 1:1 reactions. In general, isocyanates, especially aromatic and haloalkyl ones, readily undergo hydrolysis in the presence of an organic base. However, with the advantage of synthesizing the isocyanates in CHCl₃ solvent, direct addition of monoalcs. and diols to the as-prepared sample solution containing the diisocyanate allowed the one-pot syntheses of biscarbamates and polyurethanes, resp. The reactions developed in this study are simple, safe, and inexpensive methods of synthesizing N-substituted ureas and isocyanates, and derivatives of isocyanates such as carbamates and polyurethanes. The present new methods can replace current synthetic methods using COCl₂ in both academia and industry. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Quality Control of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Quality Control of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reaction of electrogenerated cyanomethyl anion with cyclohexylisocyanate: synthesis of N-(cyclohexylcarbamoyl)acetamide. An unexpected product was written by Scarano, Vincenzo;Bortolami, Martina;Pandolfi, Fabiana;Petrucci, Rita;Rocco, Daniele;Zollo, Giuseppe;Feroci, Marta. And the article was included in Journal of the Electrochemical Society in 2020.Reference of 2387-23-7 This article mentions the following:

The contamination with H₂O of the cathodic ACN-Et₄NBF₄ solution gave the authors the opportunity to study alkyl isocyanate reactivity toward electrogenerated anions. The cathodic reduction of a ACN-Et₄NBF₄ solution gave both hydroxide and cyanomethyl anions. The reaction of the catholyte with cyclohexylisocyanate led to the exclusive formation of acetamidated product, with no traces of cyanomethylated one. On the contrary, when reacting with benzaldehyde only the cyanomethylated was isolated. Considering that the acetamidated product of benzaldehyde is reported to be unstable (thus its formation cannot be excluded), various experiments were carried out to understand the anomalous reactivity of cyclohexylisocyanate. Also, computational anal. allowed to state the higher stability of acetamidated product with respect to the cyanomethylated one. The possibility of a concerted reaction, instead of acetamide anion formation prior to the reaction, is still an open question. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Reference of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Reference of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chiral, Magnetic, and Photosensitive Liquid Crystalline Nanocomposites Based on Multifunctional Nanoparticles and Achiral Liquid Crystals was written by Poryvai, Anna;Smahel, Michal;Svecova, Marie;Nemati, Ahlam;Shadpour, Sasan;Ulbrich, Pavel;Ogolla, Timothy;Liu, Jiao;Novotna, Vladimira;Veverka, Miroslav;Vejpravova, Jana;Hegmann, Torsten;Kohout, Michal. And the article was included in ACS Nano in 2022.Application of 2387-23-7 This article mentions the following:

Nanoparticles serving as a multifunctional and multiaddressable dopant to modify the properties of liquid crystalline matrixes are developed by combining cobalt ferrite nanocrystals with organic ligands featuring a robust photosensitive unit and a source of chirality from the natural pool. These nanoparticles provide a stable nanocomposite when dispersed in achiral liquid crystals, giving rise to chiral supramol. structures that can respond to UV-light illumination, and, at the same time, the formed nanocomposite possesses strong magnetic response. We report on a nanocomposite that shows three addnl. functionalities (chirality and responsiveness to UV light and magnetic field) upon the introduction of a single dopant into achiral liquid crystals. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Deep Eutectic Solvent Mediated Carbonylation of Amines and Alcohols by Using Dimethyl Carbonate: Selective Symmetrical Urea and Organic Carbonate Synthesis was written by Karimi, Farzaneh;Shariatipour, Monire;Heydari, Akbar. And the article was included in ChemistrySelect in 2021.HPLC of Formula: 2387-23-7 This article mentions the following:

This work presented one-pot synthesis of sym. organic carbonates and ureas by employing cheap and biodegradable deep eutectic solvent as the catalyst and reaction media. The effect of different reaction parameters such as temperature, DMC/amines and alcs. ratio and reaction time were investigated on the reaction efficiency. This new protocol provided a simple, fast, and sustainable approach and proceeded with high efficiency with aliphatic and aromatic amines and alcs. as well. Finally, applicability of this methodol. was also examined for reaction of nucleophiles such as Ph hydrazine and Ph glycine with di-Me carbonate. Interestingly, it was found that this reaction system obtained good yields of product for both of them. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Investigation of drug delivery in rats via subcutaneous injection: Case study of pharmacokinetic modeling of suspension formulations was written by Chiang, Po-Chang;Nagapudi, Karthik;Fan, Peter W.;Liu, Jia. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019.Related Products of 2387-23-7 This article mentions the following:

With the rising cost of drug research, “do more with less” has become a new emphasis in the pharmaceutical industry. Consequently, the early anal. of pharmacokinetic/pharmacodynamic, efficacy, and safety parameters for a new drug target is critical for ensuring informed decision-making as soon as possible during the drug discovery process. When absorption, distribution, metabolism, and excretion properties of compounds are suboptimal which is especially true during the early stages of drug discovery, obtaining the desired exposure can be challenging via the most common routes (oral, i.v.). Therefore, s.c. (SC) injection is often explored as an alternate route of delivery. Although SC injection is used widely in the industry, information about how to model and predict the absorption of drugs administered via SC injection is not readily available. In the current research, we analyzed the absorption behavior of 12 model compounds covering a wide range of physicochem. properties following SC injection. We introduced a compound-specific parameter, the absorption factor from single SC injections of suspension doses of each compound, to aid in modeling and predicting of drug absorption profiles. The pharmacokinetic models derived in this study are capable of describing and predicting the absorption properties of SC injection for individual compounds In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Buildup of Redox-Responsive Hybrid from Polyoxometalate and Redox-Active Conducting Oligomer: Its Self-Assemblies with Controllable Morphologies was written by She, Shan;Huang, Zehuan;Yin, Panchao;Bayaguud, Aruuhan;Jia, Hongli;Huang, Yichao;Wei, Yen;Wei, Yongge. And the article was included in Chemistry – A European Journal in 2017.Related Products of 2387-23-7 This article mentions the following:

A redox-responsive hybrid of polyoxometalate and conducting oligomer including its self-assemblies with controllable morphologies are reported. To this end, a hybrid mol., containing a Lindqvist hexamolybdate as the polar head group and N,N’-bis(4′-amino-2,6-dimethylphenyl)-1,4-quinonediimine as the redox-responsive and aggregating group, was prepared This hybrid exhibits redox-responsive behavior with controllable assembling morphol. transition from spherical vesicles to short cylindrical vesicles. Besides, the hybrid-based self-assemblies are transferred to the surface, thus the surface wettability can be well-tuned owing to the morphol. transitions of the self-assemblies. By marrying conducting materials with polyoxometalate chem., this research opens a new horizon of polyoxometalate-based self-assembled systems with potential applications in functional materials. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics