Category: 2387-23-7

Dual-curable isocyanate crosslinking agents blocked by methacrylate-functionalized pyrazoles with lower curing temperature was written by Kim, Soeun;Hong, Jun Ui;Ha, Miran;Noh, Seung Man. And the article was included in Progress in Organic Coatings in 2021.Name: 1,3-Dicyclohexylurea This article mentions the following:

To develop a polyurethane-based automotive clearcoat with a lower curing temperature, methacrylate-functionalized pyrazole derivatives were newly designed and synthesized as isocyanate blocking agents and their chem. structures were identified by ¹H NMR. These novel blocking agents were used to block the functional groups of hexamethylene diisocyanate (HDI) trimer (com. known as Desmodur N3300), and d. functional theory simulations were performed to predict the activation energy of the deblocking process and to determine the H-N distance in the pyrazole mols. The curing behavior of the blocked isocyanate with polyol resin at 110, 120, and 130°C was investigated using an oscillatory rheometer and a rigid-body pendulum tester. In addition, their results were compared with those for a com. available 3,5-di-Me pyrazole-blocked HDI trimer (Desmodur PL350). The thermal properties of the clearcoat films cured at 130°C were investigated using thermogravimetric anal., differential scanning calorimetry, and dynamic mech. anal., and the surface mech. properties of the cured films were evaluated using a nano-indentation tester. The novel pyrazole blocking agents contributed to lowering the deblocking temperature and enhancing the mech. properties via supplementary radical polymerization of deblocked methacrylate-functionalized pyrazoles, resulting in interpenetrating crosslinked polymer networks. This study provides a new concept of isocyanate blocking agents with lower deblocking temperatures and higher crosslinking densities, resulting in blocked isocyanates that can be used in various coating materials. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Name: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Name: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dealkenylative Alkynylation Using Catalytic Fe^II and Vitamin C was written by Swain, Manisha;Bunnell, Thomas B.;Kim, Jacob;Kwon, Ohyun. And the article was included in Journal of the American Chemical Society in 2022.Safety of 1,3-Dicyclohexylurea This article mentions the following:

In this paper, synthesis of alkyl-tethered alkynes, e.g. I through ozone-mediated and Fe^II-catalyzed dealkenylative alkynylation of unactivated alkenes in presence of alkynyl sulfones was reported. This one-pot reaction, which employed a combination of a catalytic Fe^II salt and L-ascorbic acid, proceeded under mild conditions with good efficiency, high stereoselectivity, and broad functional group compatibility. In contrast to previous Fe^II-mediated reductive fragmentation of α-methoxyhydroperoxides, Fe^II-catalyzed process was devised through a thorough kinetic anal. of multiple competing radical (redox) pathways. The potential of this dealkenylative alkynylation through multiple post-synthetic transformations and late-stage diversifications of complex mols., including natural products and pharmaceuticals was highlighted. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Safety of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water was written by Bou-Maroun, Elias;Dahbi, Laurence;Gomez-Berrada, Marie-Pierre;Pierre, Philippine;Rakotomalala, Sandrine;Ferret, Pierre-Jacques;Chagnon, Marie-Christine. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2017.Related Products of 2387-23-7 This article mentions the following:

The objective of the work was to check the presence of Non-Intended Added Substances (NIAS) with hormonal activities in aluminum coatings extracts coded: AA, BBF, MC and RR, furnished by four different suppliers. Water samples were prepared at room temperature or at 40° for three months to verify the storage effect on the coatings. Solid phase extraction was used to concentrate and to extract coating substances. Hormonal activities were checked in vitro using reporter gene bioassays. Except BBF, all extracts induced a weak but significant estrogenic agonist activity in the human cell line. Using an estrogenic antagonist (ICI-182, 780), the answer was demonstrated specific in the bioassay. RR was the only extract to induce a concentration dependent anti-androgenic response in the MDA-KB2 cell line. Anal. performed using GC-MS and HPLC-MS detected 12 substances in most of the extracts 8 NIAS were present. Among them, 4 were identified with certainty: HMBT, BGA, DCU and BPA. Estrogenic potency was BPA > DCU > BGA > HMBT. HMBT was also anti-androgenic at high concentration Combining chem. anal. and bioassays data, the authors demonstrated that in the RR and the RR40 extracts, the observed estrogenic response was mainly due to BPA, the anti-androgenic activity of RR could be due to a synergism between HMBT and BPA. For MC and AA, estrogenic responses appear to be due to the presence of DCU. Except BBF, storage conditions tended to increase estrogenic activities in all extracts However, in term of risk assessment, activities observed were negligible. This work demonstrated that sensitive bioassays are pertinent tools in complement to chem. anal. to monitor and check the presence of NIAS with hormonal activity in coating extracts In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones was written by Khramtsova, Ekaterina E.;Lystsova, Ekaterina A.;Khokhlova, Evgeniya V.;Dmitriev, Maksim V.;Maslivets, Andrey N.. And the article was included in Molecules in 2021.HPLC of Formula: 2387-23-7 This article mentions the following:

The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biol. effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones with amines). The developed approach is based on the thermal decomposition of 1,3-disubstituted urea derivatives of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, which were prepared via their reaction with carbodiimides. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Treading Water: Tire Wear Particle Leachate Recreates an Urban Runoff Mortality Syndrome in Coho but Not Chum Salmon was written by McIntyre, Jenifer K.;Prat, Jasmine;Cameron, James;Wetzel, Jillian;Mudrock, Emma;Peter, Katherine T.;Tian, Zhenyu;Mackenzie, Cailin;Lundin, Jessica;Stark, John D.;King, Kennith;Davis, Jay W.;Kolodziej, Edward P.;Scholz, Nathaniel L.. And the article was included in Environmental Science & Technology in 2021.Recommanded Product: 1,3-Dicyclohexylurea This article mentions the following:

Tire tread wear particles (TWP) are increasingly recognized as a global pollutant of surface waters, but their impact on biota in receiving waters is rarely addressed. In the developed U.S. Pacific Northwest, acute mortality of adult coho salmon (Oncorhynchus kisutch) follows rain events and is correlated with roadway d. Roadway runoff exptl. triggers behavioral symptoms and associated changes in blood indicative of cardiorespiratory distress prior to death. Closely related chum salmon (O. keta) lack an equivalent response. Acute mortality of juvenile coho was recently exptl. linked to a transformation product of a tire-derived chem. We evaluated whether TWP leachate is sufficient to trigger the acute mortality syndrome in adult coho salmon. We characterized the acute response of adult coho and chum salmon to TWP leachate (survival, behavior, blood physiol.) and compared it with that caused by roadway runoff. TWP leachate was acutely lethal to coho at concentrations similar to roadway runoff, with the same behaviors and blood parameters impacted. As with runoff, chum salmon appeared insensitive to TWP leachate at concentrations lethal to coho. Our results confirm that environmentally relevant TWP exposures cause acute mortalities of a keystone aquatic species. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tuning Synergistic Effect of Au-Pd Bimetallic Nanocatalyst for Aerobic Oxidative Carbonylation of Amines was written by Duan, Hui;Zeng, Yongfei;Yao, Xin;Xing, Pengyao;Liu, Jia;Zhao, Yanli. And the article was included in Chemistry of Materials in 2017.Electric Literature of C13H24N2O This article mentions the following:

The activation and utilization of carbon monoxide is of crucial importance to C₁ chem. Various catalytic transformation processes have been developed and studied in the last century, and oxidative carbonylation of amines is one of them. Catalysts that have been identified to date for the oxidative carbonylation of amines generally show relatively low activity and/or selectivity. Herein, a metal-organic framework (MOF), i.e., MOF-253 prepared from AlCl₃·6H₂O and 2,2′-bipyridine-5,5′-dicarboxylic acid, was employed as a support of gold-palladium bimetallic nanoparticles (Au-Pd/MOF) for the oxidative carbonylation of amines under mild conditions. Compared to palladium or gold monometallic catalysts, higher catalytic activity (turnover frequency up to 2573 h^-1) and selectivity in the carbonylation of amines were achieved by Au-Pd/MOF bimetallic catalysts through adjusting the molar ratio of gold and palladium within the framework. A breathing effect of Au-Pd/MOF in the catalytic process was further observed from kinetic profiles and powder X-ray diffraction for the first time. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Electric Literature of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Electric Literature of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

¹H NMR determination of 1,3-dicyclohexylurea, glutaric acid and triethylamine in medical four-arm poly(ethylene glycol)-N-hydroxysuccinimide-glutarate for better quality control was written by Li, Fei-Fei;Liu, Hui-Xiang;Zhang, Yan-Li;Wang, Shu-Qi. And the article was included in Analytical Methods in 2019.Application In Synthesis of 1,3-Dicyclohexylurea This article mentions the following:

Absorbable vascular sealing medical glue, which belongs to Class III medical devices, is a special new material for preventing the leakage of cerebrospinal fluid. Medical four-arm poly(ethylene glycol)-N-hydroxysuccinimide-glutarate (4-arm-PEG-SG) with a mol. weight of 20 000 is the main component of the absorbable medical glue. According to its quality standard, the quality control of residues 1,3-dicyclohexylurea (DCU), glutaric acid (GA) and triethylamine (TEA) is required. A rapid anal. method of quant. ¹H NMR (¹H NMR) for the determination of residues DCU, GA and TEA in medical 4-arm-PEG-SG was established in the present study. The peaks at δ 1.56 (4H, m), δ 2.71 (4H, t, J = 6.7 Hz), and δ 2.42 (6H, q, J = 7.2 Hz) were selected for quantifying DCU, GA and TEA, resp., with deuterated pyridine as the solvent and tetramethylsilane as the internal standard The ¹H NMR assay was validated by several exptl. parameters including specificity, linearity, accuracy, precision, robustness, limit of detection (LOD), limit of quantification (LOQ) and stability. The average recoveries obtained were in the range of 99.48-102.02% for all three residues. Compared with the HPLC and GC approaches, the proposed ¹H NMR method proved to be a powerful tool for quantification due to its unique advantages of simplicity, rapidity and high robustness, especially not requiring standard compounds for calibration curve preparation In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application In Synthesis of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Diverse Oxidative C(sp²)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides was written by Xu, Fangzhou;Wang, Yanyan;Xun, Xiwei;Huang, Yun;Jin, Zhichao;Song, Baoan;Wu, Jian. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 2387-23-7 This article mentions the following:

An efficient and chemoselective C(sp²)-N bond cleavage of aromatic imidazo[1,2-a]pyridine mols. is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quant. yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mesomorphic and geometrical orientation study of the relative position of fluorine atom in some thermotropic liquid crystal systems was written by Ahmed, H. A.;Hagar, M.;Alhaddad, O. A.. And the article was included in Liquid Crystals in 2020.Application of 2387-23-7 This article mentions the following:

New series of the Schiff base/esters, 4-((2′-or 3′-fluorophenylimino)methyl)phenyl-4”-alkoxy benzoates and 4-((3-fluorophenyl)diazenyl)phenyl 4”-alkoxy benzoates, I [X = C, N; R¹ = hexyl, octyl, decyl, etc.; R² = 2-F, 3-F ] were prepared and their mesophase behavior investigated. The type of the mesophase and its transition temperature were determined by differential scanning calorimetry (DSC) and polarised optical microscopy (POM). The optimized structures of Schiff base/ester and their azo/ester groups were deduced theor. by d. functional theory (DFT). Each group of homologues differed from the other by the position of the fluorine atom on the terminal benzene ring, in addition to laterally neat homologues. Comparative studies revealed that the position and orientation of the lateral fluorine atom as well as the type of the linking core not only affected the melting temperature but also the mesophase stability. DFT results showed that the type and stability of the mesophase could be illustrated in the terms of calculated dipole moment, polarisability, thermal energy and mol. electrostatic potential. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Development of suspect and non-target screening methods for detection of organic contaminants in highway runoff and fish tissue with high-resolution time-of-flight mass spectrometry was written by Du, Bowen;Lofton, Jonathan M.;Peter, Katherine T.;Gipe, Alexander D.;James, C. Andrew;McIntyre, Jenifer K.;Scholz, Nathaniel L.;Baker, Joel E.;Kolodziej, Edward P.. And the article was included in Environmental Science: Processes & Impacts in 2017.SDS of cas: 2387-23-7 This article mentions the following:

Untreated urban stormwater runoff contributes to poor water quality in receiving waters. The ability to identify toxicants and other bioactive mols. responsible for observed adverse effects in a complex mixture of contaminants is critical to effective protection of ecosystem and human health, yet this is a challenging anal. task. The objective of this study was to develop anal. methods using liquid chromatog. coupled to high-resolution quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) to detect organic contaminants in highway runoff and in runoff-exposed fish (adult coho salmon, Oncorhynchus kisutch). Processing of paired water and tissue samples facilitated contaminant prioritization and aided investigation of chem. bioavailability and uptake processes. Simple, minimal processing effort solid phase extraction (SPE) and elution procedures were optimized for water samples, and selective pressurized liquid extraction (SPLE) procedures were optimized for fish tissues. Extraction methods were compared by detection of non-target features and target compounds (e.g., quantity and peak area), while minimizing matrix interferences. Suspect screening techniques utilized inhouse and com. databases to prioritize high-risk detections for subsequent MS/MS characterization and identification efforts. Presumptive annotations were also screened with an inhouse linear regression (log K_owvs. retention time) to exclude isobaric compounds Examples of confirmed identifications (via reference standard comparison) in highway runoff include ethoprophos, prometon, DEET, caffeine, cotinine, 4(or 5)-methyl-1H-methylbenzotriazole, and acetanilide. Acetanilide was also detected in runoff-exposed fish gill and liver samples. Further characterization of highway runoff and fish tissues (14 and 19 compounds, resp. with tentative identification by MS/MS data) suggests that many novel or poorly characterized organic contaminants exist in urban stormwater runoff and exposed biota. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics