Category: 2387-23-7

Suspect and non-target screening of contaminants of emerging concern in streams in agricultural watersheds was written by Tian, Zhenyu;Wark, David A.;Bogue, Kevin;James, C. Andrew. And the article was included in Science of the Total Environment in 2021.Application In Synthesis of 1,3-Dicyclohexylurea This article mentions the following:

Surface water runoff is an important source of water contamination affecting nearby rivers and streams. Many rural creeks are documented habitats for important aquatic species and the focus of restoration activities. In this study, we collected creek water samples in watersheds with a range of com.-to-agricultural land use during rain events, and applied suspect and non-target screening with high-resolution mass spectrometry (HRMS) to characterize the occurrence of contaminants of emerging concern (CECs). In total, 58 CECs were identified, and 36 of them were confirmed and semi-quantified with reference standards Pesticides were detected in all land use, including urban/com. areas. Some pesticides were observed at concentrations of >10,000 ng/L demonstrating the strong contamination input during rain events. Five pesticides (azoxystrobin, fludioxonil, 4-hydroxy-chlorothalonil, imidacloprid, 2-methyl-4-chlorophenoxyacetic acid) were prioritized based on their risk quotients. HRMS chem. profiles demonstrated the wide range of chem. exposures in a given stream system and that compounds associated with specific land uses occur across land uses. Temporal trends suggested that some CECs remain present in creek water for months, resulting in chronic exposures across the life stages of aquatic species. These findings highlight the potential for contamination from agricultural runoff and the associated ecol. risk to aquatic species. Suspect and non-target screening revealed the chronic occurrence of emerging contaminants in streams in agricultural catchments during rain events. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application In Synthesis of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structure and activity relationship studies of N-heterocyclic olefin and thiourea/urea catalytic systems: application in ring-opening polymerization of lactones was written by Zhou, Li;Wang, Zhenyu;Xu, Guangqiang;Lv, Chengdong;Wang, Qinggang. And the article was included in Polymer Chemistry in 2021.HPLC of Formula: 2387-23-7 This article mentions the following:

A highly efficient and controllable ring-opening polymerization of lactones (δ-valerolactone, ε-caprolactone and rac-lactide) has been achieved by using N-heterocyclic olefin (NHO) and thiourea/urea (TU/U) catalytic systems. This catalytic system showed high ring-opening activity and stereoselectivity, delivering biodegradable polyesters with high chain-end fidelity, controlled mol. weights and narrow molar mass dispersities. A detailed investigation of the structure-activity relationship was performed by exploring five NHOs and fourteen TUs/Us. For a fixed NHO, when the acidity of TUs/Us decreases, the polymerization mechanism changes from the (thio)urea anion to the neutral cooperative activation mode, and the catalytic activity first increases and decreases, displaying a highly effective interval. For a given TU or U, as the basicity of NHOs increases, the catalytic performance improves correspondingly. Besides, highly isoselective ROP of rac-LA (Pm = 0.93) at -78° has been also achieved, highlighting the versatility of the NHO/TU(U) system. These findings enrich the type of TU/U and base organocatalyst. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of α,δ-Disubstituted Tetraphosphates and Terminally-Functionalized Nucleoside Pentaphosphates was written by Shepard, Scott M.;Kim, Hyehwang;Bang, Qing Xin;Alhokbany, Norah;Cummins, Christopher C.. And the article was included in Journal of the American Chemical Society in 2021.Formula: C13H24N2O This article mentions the following:

The anion [P₄O₁₁]^2-, employed as its bis(triphenylphosphine)iminium (PPN) salt, is shown herein to be a versatile reagent for nucleophile tetraphosphorylation. Treatment under anhydrous conditions with an alkylamine base and a nucleophile (HNuc¹), such as an alc. (neopentanol, cyclohexanol, 4-methylumbelliferone, and Boc-Tyr-OMe), an amine (propargylamine, diethylamine, morpholine, 3,5-dimethylaniline, and isopropylamine), dihydrogen phosphate, phenylphosphonate, azide ion, or methylidene triphenylphosphorane, results in nucleophile substituted tetrametaphosphates ([P₄O₁₁Nuc¹]^3-) as mixed PPN and alkylammonium salts in 59% to 99% yield. Treatment of the resulting functionalized tetrametaphosphates with a second nucleophile (HNuc²), such as hydroxide, a phenol (4-methylumbelliferone), an amine (propargylamine and ethanolamine), fluoride, or a nucleoside monophosphate (uridine monophosphate, deoxyadenosine monophosphate, and adenosine monophosphate), results in ring opening to linear tetraphosphates bearing one nucleophile on each end ([Nuc¹(PO₃)₃PO₂Nuc²]^4-). When necessary, these linear tetraphosphates are purified by reverse phase or anion exchange HPLC, yielding triethylammonium or ammonium salts in 32% to 92% yield from [PPN]₂[P₄O₁₁]. Phosphorylation of methylidene triphenylphosphorane as Nuc¹ yields a new tetrametaphosphate-based ylide ([Ph₃PCHP₄O₁₁]^3-, 94% yield). Wittig olefination of 2′,3′-O-isopropylidene-5′-deoxy-5′-uridylaldehyde using this ylide results in a 3′-deoxy-3′,4′-didehydronucleotide derivative, isolated as the triethylammonium salt in 54% yield. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palladium/Norbornene Chemistry in the Synthesis of Polycyclic Indolines with Simple Nitrogen Sources was written by Ghasemi, Mehran;Jafarpour, Farnaz;Habibi, Azizollah. And the article was included in Synthesis in 2020.Application In Synthesis of 1,3-Dicyclohexylurea This article mentions the following:

An efficient procedure has been developed to synthesize indoline derivatives, e.g., I, through a palladium-catalyzed Heck reaction/C-H activation/dual amination cascade in one pot. This constitutes the first intermol. catalytic approach to directly access N-alkylindolines with a broad substrate scope in the absence of any ligands. This method highlights the use of readily available amines and ureas as the required nitrogen sources in building up the indoline core. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application In Synthesis of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application In Synthesis of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Intermolecular cyclotrimerization of haloketoalkynes and internal alkynes: facile access to arenes and phthalides was written by Silvestri, A. P.;Oakdale, J. S.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Recommanded Product: 2387-23-7 This article mentions the following:

A highly chemo- and regioselective cyclo(co)trimerization between 3-halopropiolamides RC(O)CCX [R = dimethylaminyl, morpholin-4-yl, 4-(ethoxycarbonyl)piperidin-1-yl, 4-([3-(propan-2-yloxy)propyl]carbamoyl)piperidin-1-yl, etc.; X = H, Br, Cl] and internal alkynes R¹CCR² [R¹ = H, n-Bu, 4-cyanophenyl, thiophen-3-yl, etc.; R² = H, Me, 4-methoxyphenyl, thiophen-3-yl, etc.; R¹R² = -(CH₂)₁₀-] is reported. The reaction is catalyzed by CpRuCl(COD) and proceeds under air at ambient temperature in ethanol with no addnl. precautions. Iodo-, bromo-, and chloropropiolamides, esters, and ketones are viable coupling partners and, in a 2:1 stoichiometry relative to internal alkyne, yield fully-substituted arenes I and II in a single step. The highest regioselectivities (96% single isomer) were observed when employing 2° and 3°-halopropiolamides. A mechanistic hypothesis accounting for this selectivity is proposed. Notably, by using 1,4-butynediol as the internal alkyne, in situ lactonization following [2+2+2]-cycloaddition generates therapeutically-relevant phthalide pharmacophores III directly. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Conformationally locked cis-1,2-diaminocyclohexane-based chiral ligands for asymmetric catalysis was written by van Beek, Carim;Samoshin, Vyacheslav V.. And the article was included in Tetrahedron Letters in 2022.SDS of cas: 2387-23-7 This article mentions the following:

An efficient synthesis for a new conformationally locked chiral cis-1,2-diaminocyclohexane scaffold was developed. The conformational lock allows for convenient sym. derivatization of the amino groups through the reductive amination strategy. A series of optically pure chiral ligands I [R = Bn, 2-HOC₆H₄CH₂, 2-MeOC₆H₄CH₂] based on the cis-DACH scaffold was generated to demonstrate a proof-of-concept for these ligands as chiral catalysts in the asym. Henry reaction. Excellent yields with moderate enantioselectivity were demonstrated at room temperature, with an increase in enantioselectivity at lower temperatures, showing the potential of this new type of cis-DACH ligand. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Precise growth of polymer brushes on silica-based nanocomposites via visible-light-regulated controlled radical polymerization was written by Li, Xue;Ye, Sunjie;Huang, Ya;Li, Jia Le;Cai, Tao. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019.Category: amides-buliding-blocks This article mentions the following:

Precise control over mol. variables of grafted polymer brushes is of crucial importance for obtaining polymer nanocomposites with desirable architectures and physicochem. properties, yet it remains a significant synthetic challenge. Recent advances in photoinduced electron/energy transfer reversible addition fragmentation chain transfer (PET-RAFT) polymerization have enabled light-regulated polymer synthesis, in a well-controlled and environmentally friendly manner. However, the utilization of this modern synthetic technique for the precise control of polymer brushes is underdeveloped. Here, PET-RAFT polymerization has been proceeded in a spatiotemporally controlled manner upon light regulation, producing silica nanocomposites coated with well-defined polymer brushes of target mol. weights, narrow dispersities and high grafting densities. The versatility and robustness of this technique have been demonstrated by its extendibility to other monomers and silica-containing nanomaterials. In all examined cases, the resultant high-value polymer nanocomposites possess defined chain sequences and architectures, high uniformity, and can be further expanded to a library of complex nanostructures. This work represents the first demonstration of adopting the PET-RAFT approach for generating precisely controlled polymer brushes on silica-based nanomaterials, and opens a new avenue for developing polymer nanocomposites with sequence-controlled polymer brushes and complex architectures required for a variety of target applications. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Graphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions was written by Patel, Khushbu P.;Gayakwad, Eknath M.;Patil, Vilas V.;Shankarling, Ganapati S.. And the article was included in Advanced Synthesis & Catalysis in 2019.HPLC of Formula: 2387-23-7 This article mentions the following:

An environment-friendly, inexpensive, carbocatalyst, graphene oxide (GO) which promoted efficient, metal-free transamidation of various carboxamides RC(O)NH₂ (R = Ph, pyridin-2-yl, H, Me, etc.) with aliphatic, cyclic, and aromatic amines NH(R¹)(R²) [R¹ = H, Ph; R² = n-Bu, Ph, cyclohexyl, pyridin-2-yl, etc.; R¹R² = -(CH₂)₄-, -CH₂CH₂OCH₂CH₂-] and 2-aminothiophenol is demonstrated. The protocol is equally applicable to phthalimides such as 1H-isoindole-1,3(2H)-dione, 5-methyl-1H-isoindole-1,3(2H)-dione, ureas R³NHC(O)NH₂ (R³ = H, Ph), and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (-C=O), epoxy (-O-), carboxyl (-COOH) and hydroxyl (-OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products RC(O)N(R¹)(R²), I, R¹NHC(O)NHR² in good to excellent yields. The one-pot synthesis of 2,3-dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramol. transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Phytosterol recognition via rationally designed molecularly imprinted polymers was written by Schwarz, Lachlan J.;Leung, Brenda K. Y.;Danylec, Basil;Harris, Simon J.;Boysen, Reinhard I.;Hearn, Milton T. W.. And the article was included in C in 2018.Category: amides-buliding-blocks This article mentions the following:

Molecularly imprinted polymers (MIPs) prepared via a semi-covalent imprinting strategy using stigmasteryl methacrylate as a polymerizable template have been evaluated by static binding methods for their ability to selectively capture other valuable phytosterol targets, including campesterol and brassicasterol. Design criteria based on mol. modeling procedures and interaction energy calculations were employed to aid the selection of the co-monomer type, as well as the choice of co-monomer:template ratios for the formation of the pre-polymerization complex. These novel hybrid semi-covalently imprinted polymers employed N,N’-dimethylacryl-amide (N,N’-DMAAM) as the functional co-monomer and displayed specific binding capacities in the range 5.2-5.9 mg sterol/g MIP resin. Their binding attributes and selectivities towards phytosterol compounds were significantly different to the corresponding MIPs prepared via non-covalent procedures or when compared to non-imprinted polymers. Cross-reactivity studies using stigmasterol, ergosterol, cholesterol, campesterol, and brassicasterol as single analytes revealed the importance of the A-ring C-3-β-hydroxyl group and the orientational preferences of the D-ring alkyl chain structures in their interaction in the templated cavity with the N,N’-dimethylamide functional groups of the MIP. Finally, to obtain useful quantities of both campersterol and brassicasterol for these investigations, improved synthetic routes have been developed to permit the conversion of the more abundant, lower cost stigmasterol via a reactive aldehyde intermediate to these other sterols. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Providing a New Aniline Bioisostere through the Photochemical Production of 1-Aminonorbornanes was written by Staveness, Daryl;Sodano, Taylor M.;Li, Kangjun;Burnham, Elizabeth A.;Jackson, Klarissa D.;Stephenson, Corey R. J.. And the article was included in Chem in 2019.Formula: C13H24N2O This article mentions the following:

The photochem. conversion of aminocyclopropanes into 1-aminonorbornanes via formal [3 + 2] cycloadditions initiated by homolytic fragmentation of amine radical cation intermediates was described. Aligned with the modern movement toward sp³-rich motifs in drug discovery, this strategy provided access to a diverse array of substitution patterns on this saturated carbocyclic framework while offered the robust functional-group tolerance (e.g., -OH, -NHBoc) necessary for further derivatization. The metabolic stability was evaluated for selected morpholine-based 1-aminonorbornanes demonstrated a low propensity for oxidative processing and no proclivity toward reactive metabolite formation, suggested a potential bioisosteric role for 1-aminonorbornanes. Continuous-flow processing allowed for efficient operation on the gram scale, provided promise for translation to industrially relevant scales. This methodol. only required low loadings of a com. available, visible-light-active photocatalyst and a simple salt; thus, it stayed true to sustainability goals while readily delivered saturated building blocks that reduced metabolic susceptibility within drug development programs. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics