In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22961-58-6, name is 5-Amino-2-methoxybenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-Amino-2-methoxybenzamide
EXAMPLE 67 3′-Methoxy-2′-methylcarbamoyloxanilic acid ethyl ester. 72 Slow addition of 4.98 g. (0.03 mole) of 5-amino-o-anisamide to a mixture of 57% NaH (1.32 g., 0.0315 mole) in 50 ml. dimethylformamide was carried out at room temperature. After the evolution of H2 ceased, the mixture was cooled to 3 C. and 2.06 ml. (0.033 mole) of methyliodide was slowly added at 3-5 C. The temperature was allowed to go up to room temperature and stir for 2 hours. The mixture was concentrated, the residue extracted into ethylacetate-water, the mixture was basified, and the ethylacetate layer was washed with water, brine and dried. Concentration gave a tan solid that was crystallized (ethanol), giving 0.45 g. (8%) of 6-amino-N-methyl-o-anisamide mp. 186-189 C.
The synthetic route of 22961-58-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Home Products Corporation; US4054661; (1977); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics