22958-64-1 Archives - Amides-buliding-blocks

Sources of common compounds: 2-(4-Sulfamoylphenyl)acetic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Sulfamoylphenyl)acetic acid, and friends who are interested can also refer to it.

Synthetic Route of 22958-64-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22958-64-1 name is 2-(4-Sulfamoylphenyl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00361] To a solution of 2-amino-6-(2,2,2-trifluoro-1 -phenylethyl)-4,5,6,7- tetrahydrothieno[2,3-c]pyridine-3-carbonitrile (Intermediate Core-2a_D) (60 mg, 0.178 mmol), 2- (4-sulfamoylphenyl)acetic acid Core-2a_6d (60 mg, 0.267 mmol), DIPEA (46 mg, 0.356 mmol) in DMF (10 ml.) was added aq. T3P (50% in EtOAc) (170 mg, 0.267 mmol) at 20 C. The mixture was stirred at 20 C for 1 h. The reaction was concentrated to oil and diluted with EtOAc (10 ml_), washed with brine, dried over Na2S04 and filtered. The filtrate was concentrated to a yellow oil, which was purified by prep-HPLC (base) to get A/-(3-cyano-6-(2,2,2-trifluoro-1 – phenylethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide (18 mg, yield: 18%) as a yellow solid; 1H NMR (400 MHz, CD3OD) d 7.88 (d, =8.41Hz, 2H), 7.37- 7.59 (m, 7H), 4.51 -4.58 (m, 1H), 3.94 (s, 2H), 3.66-3.84 (m, 2H), 3.06-3.19 (m, 1H), 2.78-2.92 (m, 1H), 2.56-2.72 (m, 2H); LC-MS Rt 0.945 min, MS m/z [M+H]+ 535.1, Method 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Sulfamoylphenyl)acetic acid, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; KOUNDE, Cyrille; SIM, Wei Lin Sandra; SIMON, Oliver; WANG, Gang; YEO, Hui Quan; YEUNG, Bryan KS; YOKOKAWA, Fumiaki; ZOU, Bin; (122 pag.)WO2019/244047; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analyzing the synthesis route of 22958-64-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Sulfamoylphenyl)acetic acid, other downstream synthetic routes, hurry up and to see.

Application of 22958-64-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22958-64-1, name is 2-(4-Sulfamoylphenyl)acetic acid belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00324] To a solution of 2-amino-5-(cyclohexylmethyl)-6,6-dimethyl-4, 5,6,7- tetrahydrothieno[3,2-c]pyridine-3-carbonitrile Core-1 c_A (1.15 g, 3.8 mmol) in DMF (12 mL) was added 2-(4-sulfamoylphenyl)acetic acid (1.23 g, 5.7 mmol), DIPEA (982 mg, 7.6 mmol) and a solution of T3P in EtOAc (4.84 g, 50% w/w, 7.6 mmol). The mixture was stirred at 65 C for 1 h. The reaction mixture was diluted with water (25 mL) and extracted with EtOAc (15 mLx4). The organic layer was concentrated. The residue was purified by column chromatography on silica (PE:EtOAc=10:1 ~2:1) to afford the desired product (1.15 g, yield 60%) as light yellow solid; LC-MS Rt 1.08 min, MS m/z [M+H]+ 501.3; Method 1 ; 1H NMR (400 MHz, DMSO-cfe) d 1 1.9 (s, 1H), 7.78 (d, J = 8.4 Hz, 2H), 7.48 (d, J = 8.4 Hz, 2H), 7.33 (s, 2H), 3.96 (s, 2H), 3.49 (s, 2H), 2.46 (s, 2H), 2.24 (d, J = 6.8 Hz, 2H), 1.76 – 1.73 (m, 2H), 1.67 – 1.64 (m, 3H), 1.39 – 1.33 (m, 1H), 1.25 – 1.15 (m, 3H), 1.02 (s, 6H), 0.88 – 0.75 (m, 2H).

Share a compound : 22958-64-1

The synthetic route of 2-(4-Sulfamoylphenyl)acetic acid has been constantly updated, and we look forward to future research findings.

22958-64-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22958-64-1, name is 2-(4-Sulfamoylphenyl)acetic acid belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00382] 1H NMR (400 MHz, DMSO-cfe) d 7.80 – 7.74 (m, 2H), 7.48 (d, J= 8.4 Hz, 2H), 7.41 – 7.29 (m, 3H), 7.22 – 7.15 (m, 2H), 7.07 (td, J= 8.3, 1.8 Hz, 1H), 3.95 (s, 2H), 3.75 (s, 2H), 2.81 – 2.64 (m, 8H); LC-MS Rt 0.53 min, MS m/z [M+H]+ 499.4

The synthetic route of 2-(4-Sulfamoylphenyl)acetic acid has been constantly updated, and we look forward to future research findings.