Category: 227940-71-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 227940-71-8

7-Benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (0.49 g, 1.6 mmol) was dissolved in methanol (20 ml.) and 20% Pd(OH)2/C (wet) (~ 2 g) was added under a nitrogen atmosphere. This mixture was warmed to about 50 0C and shaken for 2 h under 55 psi of hydrogen. The resulting mixture was filtered and concentrated to give 0.32 g (94% yield) of the title compound (MS m/z 227 (M+H)).

The synthetic route of 227940-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGACEPT, INC.; WO2009/111550; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: amides-buliding-blocks

7-Benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (0.49 g, 1.6 mmol) was dissolved in methanol (20 ml.) and 20% Pd(OH)2/C (wet) (~ 2 g) was added under a nitrogen atmosphere. This mixture was warmed to about 50 0C and shaken for 2 h under 55 psi of hydrogen. The resulting mixture was filtered and concentrated to give 0.32 g (94% yield) of the title compound (MS m/z 227 (M+H)).

The synthetic route of 227940-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGACEPT, INC.; WO2009/111550; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 227940-71-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 227940-71-8 as follows.

Example 8: Synthesis of 3,7-diazabicyclo[3.3.1]nonane-3-carboxyIic acid tert-butyl esterExample 8 relates to the synthesis of 3,7-diazabicyclo[3.3.1]nonane-3- carboxylic acid tert-butyl ester (or N-(tert-butoxycarbonyl)-3,7- diazabicyclo[3.3.1]nonane), which was prepared according to the following techniques:7-Benzyl-3,7-diazabicyclo [3.3.1 ] nonane-3-carboxylic acid tert-butyl ester (or N-benzyl-N’-(tert-butoxycarbonyI)-3,7- diazabicyclo[3.3.1]nonane); 7-Benzyl-3,7-diazabicyclo [3.3.1] nonane-3-carboxylic acid tert-butyl ester was prepared according to procedures set forth by Stead et al. in Org. Lett. 7(20): 4459 (2005).3,7-Diazabicyclo[3.3.1]-3-carboxyIic acid tert-butyl ester 7-Benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester(0.49 g, 1.6 mmol) was dissolved in methanol (20 mL) and 20% Pd(OH)2/C (wet) (~ 2 g) was added under a nitrogen atmosphere. This mixture was warmed to about 5O0C and shaken for 2 h under 55 psi of hydrogen. The resulting mixture was EPO filtered and concentrated to give 0.32 g (94% yield) of the title compound (MS m/z 227 (M+H)).

According to the analysis of related databases, 227940-71-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TARGACEPT, INC.; WO2008/57938; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 227940-71-8, Safety of tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Trifluoro acetic acid (TFA) (2.25ml, 5eq, 0.03 mol) was injected to the stirring suspension of compound 12 (2.0g, l eq, 0.006mol) in DCM at 0C and allowed to stir at 25C (25-35C). Then reaction mixture was made alkaline by adding 20% aq. solution of Na2C03 and resulting mixture was extracted with dichloromethane (3 chi 50ml) and organics were washed with brine. The combined organics were dried with anhydrous Sodium sulphate and concentrated to obtain yellow oily liquid ( 1.641 g). Yield: 90% ; IR(Neat): 3451.4, 2924.6, 1610.0, 1450.4 cm” ;1H NMR (300MHz, CDC13, ppm): 87.37-7.27 (m, 5H, Ph-H); 3.49-3.41 (m, 4H, ChbPh, 2xNCH); 3.31-3.27 (d, J=12Hz, 2H, 2*NCH); 3.19-3.1 1 (m, 2H, 2> NCH); 2.49-2.45 (d, J=12Hz, 2H, 2xNCH); 2.12-2.07 (m, 2H, 2*CH); 1.93- 1.89 (d, J= 12Hz, I H, bridge CH); 1.79- 1.75 (d, J=12Hz, IH, bridge CH); MS (ESI):m/z = 217 (M+H)+

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Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; DIKSHIT, Dinesh Kumar; KARUNAKARAN SASIKALA, Anil Kumar; DIKSHIT, Madhu; BARTHWAL, Manoj Kumar; MISRA, Ankita; JAIN, Manish; WO2015/44951; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

To a solution of 3 (350 mg, 1.11 mmol) in 30mL of dry ethanol was added 28 % of the Pd, 10 wt. % on activated carbon, and H2 was bubbled through the reaction mixture for 4 hrs. The reaction was monitored by TLC. The solution was filtered through a sintered funnel and evaporated to yield 230 mg of the product 4. Yield: 92 %. (HRMS): calcd for C12H23N2O2 m/z 227.1760, found m/z 227.1750

The synthetic route of 227940-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Haridas; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh; Tetrahedron Letters; vol. 53; 6; (2012); p. 623 – 626;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C19H28N2O2

(v) tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The sub-title compound was prepared in quantitative yield according to the procedure described in step (iii) above, using tert-butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (from step (iv) above) in place of 3,7-dibenzyl-3,7-diazabicyclo[3.3.1]nonane. 13C NMR in CDCl3: delta 28.05, 28.29, 31.33, 48.35, 49.11, 51.53, 79.34, 155.16

The synthetic route of 227940-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AstraZeneca AB; US6465481; (2002); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics