Category: 226260-01-1

Bolduc, Trevor G. et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 226260-01-1

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide

Thionyl fluoride-mediated one-pot substitutions and reductions of carboxylic acids was written by Bolduc, Trevor G.;Lee, Cayo;Chappell, William P.;Sammis, Glenn M.. And the article was included in Journal of Organic Chemistry in 2022.Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide This article mentions the following:

Thionyl fluoride (SOF2) is an underutilized reagent that is yet to be extensively studied for its synthetic applications. We previously reported that it is a powerful reagent for both the rapid syntheses of acyl fluorides and for one-pot peptide couplings, but the full scope of these nucleophilic acyl substitutions had not been explored. Herein, we report one-pot thionyl fluoride-mediated syntheses of peptides and amides (35 examples, 45-99% yields) that were not explored in our previous study. The scope of thionyl fluoride-mediated nucleophilic acyl substitutions was also expanded to encompass esters (24 examples, 64-99% yields) and thioesters (11 examples, 24-96% yields). In addition, we demonstrate that the scope of thionyl fluoride-mediated one-pot reactions can be extended beyond nucleophilic acyl substitutions to mild reductions of carboxylic acids using NaBH4 (13 examples, 33-80% yields). In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of 3-Fluoro-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Plessel, Kristin N. et al. published their research in Organic Letters in 2015 | CAS: 226260-01-1

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 226260-01-1

A Rapid Injection NMR Study of the Reaction of Organolithium Reagents with Esters, Amides, and Ketones was written by Plessel, Kristin N.;Jones, Amanda C.;Wherritt, Daniel J.;Maksymowicz, Rebecca M.;Poweleit, EricT.;Reich, Hans J.. And the article was included in Organic Letters in 2015.Related Products of 226260-01-1 This article mentions the following:

Unexpectedly high rates of reaction between alkyllithium reagents and amides, compared to esters and ketones, were observed by Rapid Inject NMR and competition experiments Spectroscopic investigations with 4-fluorophenyllithium (ArLi, mixture of monomer and dimer in THF) and a benzoate ester identified two reactive intermediates, a homodimer of the tetrahedral intermediate, stable below -100 °C, and a mixed dimer with ArLi. Direct formation of dimers suggested that the ArLi dimer may be the reactive aggregate rather than the usually more reactive monomer. In contrast, RINMR experiments with ketones demonstrated that the ArLi monomer was the reactive species. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Related Products of 226260-01-1).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 226260-01-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Aravindan, Narasingan et al. published their research in Organic Letters in 2022 | CAS: 226260-01-1

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Computed Properties of C9H10FNO2

A Ruthenium-Catalyzed Cyclization to Dihydrobenzo[c]phenanthridinone from 7-Azabenzonorbornadienes with Aryl Amides was written by Aravindan, Narasingan;Vinayagam, Varathan;Jeganmohan, Masilamani. And the article was included in Organic Letters in 2022.Computed Properties of C9H10FNO2 This article mentions the following:

An efficient ruthenium(II)-catalyzed tandem C-C/C-N bond formation with aryl amides and 7-azabenzonorbornadienes was developed to synthesize cis-fused dihydrobenzo[c]phenanthridinones. The amide group functions as a directing group as well as a leaving group and provided an easy access to the pharmaceutically useful benzo[c]phenanthridine alkaloids such as nitidine and fagaronine analogs. The present methodol. was compatible with various functional groups with respect to azabicyclic alkenes and aromatic amides. The reaction mechanism involving directing-group-assisted C-H activation was proposed and supported by the deuterium labeling studies. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Computed Properties of C9H10FNO2).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Computed Properties of C9H10FNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Brief introduction of 226260-01-1

The chemical industry reduces the impact on the environment during synthesis 3-Fluoro-N-methoxy-N-methylbenzamide. I believe this compound will play a more active role in future production and life.

Electric Literature of 226260-01-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 226260-01-1, name is 3-Fluoro-N-methoxy-N-methylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.

Example 5 1-(3-FLUOROPHENYL) BUTAN-1-ONE To a solution of 3-fluoro-N-methoxy-N-methylbenzamide (130 mg, 0.71 mmol) in dry THF (2 mL) cooled to-10 C was added propyl magnesium chloride (532 ul, 2M solution in ether, 1.1 mmol) under nitrogen. The solution was stirred at-10 C for Ih and at room temperature for 75 min. The solution was the poured into saturated aqueous ammonium chloride and the product extracted into ethyl acetate (3 x 25 mL). The organic layers were combined, washed with brine, dried (MGSO4) and concentrated to give a pale yellow oil, which was purified by chromatography using ethyl acetate-hexane (1: 9) to separate the pure product (78 mg, 66%). ‘H-N. m. r. (CDCl3) No. 1.01 (t, =7. 4Hz, 3H, Me), 1.77 (sep, 2H, CH2CH3), 2.93 (T, J=7. 2Hz, 2H, COCH2), 7.15-7. 30 (m, 1H, Ar), 7.35-7. 50 (m, 1H, Ar), 7.60-7. 70 (m, 1H, Ar), 7.70-7. 80 (m, 1H, Ar.

The chemical industry reduces the impact on the environment during synthesis 3-Fluoro-N-methoxy-N-methylbenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CYTOPIA PTY LTD; WO2004/52868; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Continuously updated synthesis method about 3-Fluoro-N-methoxy-N-methylbenzamide

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 226260-01-1, name is 3-Fluoro-N-methoxy-N-methylbenzamide, A new synthetic method of this compound is introduced below., 226260-01-1

2. 35 ml of a 1 molar solution of vinylmagnesium bromide in THF is added dropwise under nitrogen to a solution, held at 0 C., of 5.80 g (31.6 mmol) of 3-fluoro-N-methoxy-N-methylbenzamide in 70 ml of THF.The reaction mixture is stirred at room temperature for 40 minutes, then saturated ammonium chloride solution is added, and the mixture is stirred at room temperature for a further 10 minutes. tert-Butyl methyl ether is added to the reaction mixture. The organic phase is separated off, washed with sodium hydrogencarbonate solution and water and dried in vacuo: 1-(3-fluorophenyl)-3-(methoxymethylamino)propan-1-one as yellow oil; ESI 212.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dorsch, Dieter; Schadt, Oliver; Blaukat, Andree; US2008/249095; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics