Adding a certain compound to certain chemical reactions, such as: 220798-52-7, name is 3-Bromomethylbenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 220798-52-7, category: amides-buliding-blocks
625 mg (2.50 mmol) 3-(bromomethyl)benzenesulfonamide and 851 mg (12.5 mmol) 1H-pyrazole were solved in 25 ml acetonitrile and heated under reflux for 16 h. The cooled solution was poured into water and saturated sodium hydrogencarbonate solution was added until neutral reaction. The aqueous phase was extracted three times with methylenchloride, dried over magnesium sulfate and concentrated in vacuo. To remove impurities of pyrazole the residue was taken up in methylenchloride and washed withabout 10 ml 1 N aqueous hydrochloric acid. After drying and solvent evaporation 310 mg (purity 96.5%, 50.4 % of theory) of 3-(1H-pyrazol-1 -ylmethyl)benzenesulfonamide.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromomethylbenzenesulfonamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER CROPSCIENCE AG; GREUL, Joerg; HEIL, Markus; JESCHKE, Peter; MUeLLER, Klaus-Helmut; ILG, Kerstin; MALSAM, Olga; PORTZ, Daniela; WO2015/7668; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics