Synthetic Route of 207405-60-5, These common heterocyclic compound, 207405-60-5, name is tert-Butyl 5-hydroxy-2-aza-bicyclo[2.2.1]heptane-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of 2-Aza-2-(t-butoxycarbonyl)bicyclo[2.2.1]heptan-5-one STR36 Dimethylsulfoxide (85.9 mmol) was added to a solution of oxalyl chloride (39.5 mmol) in dichloromethane (100 mL) at -78– C. Stirred for 20 minutes whereupon [exo]2-aza-2-(t-butoxycarbonyl)-bicyclo[2.2.1]heptan-5-ol (35.7 mmol) in dichloromethane (50 mL). Stirred at -78– C. for 3 hours then triethylamine (179 mmol) was added to the reaction then warmed to room temperature for one hour. Brine was added then the reaction was extracted with dichloromethane (3*200 mL). The organic extracts were dried over magnesium sulfate then evaporated. The residue was purified by preparative HPLC over silica gel eluding with 10% to 75% ethyl acetate in hexanes to yield 2-aza-2-(t-butoxycarbonyl)-bicyclo[2.2.1]heptan-5-one (31.3 mmol).
The synthetic route of 207405-60-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eli Lilly and Company; US6124312; (2000); A;,
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