Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 201162-53-0, name is 3-Boc-3,8-Diazabicyclo[3.2.1]octane, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks
3,8-diazabicyclo [3.2.1] octane-3-carboxylic acid tert-butyl ester (318 mg, 1.5 mmol)And 2-chloro-5- (chloromethyl) erythropine (243 mg, 1.5 mmol) were dissolved in acetonitrile (50 mL)Potassium carbonate (414 mg, 3.0 mmol) was added and reacted at 70 C for 16 hours.After cooling to room temperature, ethyl acetate (10 mL) and water (50 mL) were added,The aqueous phase was extracted with ethyl acetate (150 mL X3), the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound (480 mg, 95% yield) as a pale yellow oil.
The synthetic route of 201162-53-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu, Yongqian; (45 pag.)CN104910137; (2017); B;,
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