Category: 19982-07-1

Reference of 19982-07-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, SMILES is CC(NC12CC3(C)CC(C2)(C)CC(C3)C1)=O, belongs to amides-buliding-blocks compound. In a article, author is Cobos, Ana, introduce new discover of the category.

Selectively convert fructose to furfural or hydroxymethylfurfural on Beta zeolite: The manipulation of solvent effects

The selective synthesis of furfural or hydroxymethylfurfural (HMF) from fructose on single catalyst (Beta zeolite, 1113) is challenging task. However, in this study, selectivity of H beta zeolite was discovered easily to tune by solvent effects. Strong solvent effects on the selectivity of fructose conversion were observed in different manners depending on the solvent used. It was shown that the coordinated state of framework aluminum, induced by solvent effects, has a major impact on the selectivity. The solvents with amide group were discovered to induce the reversible tetrahedral-octahedral framework aluminum transformation, but the configuration of aluminum was no influenced by other solvents such as gamma-butyrolactone (GBL). Compared with other solvents, the GBL was not able to enhance turnover frequency (TOF) value of reaction but also suppress the degradation of furfural. Interestingly, a considerable yield of furfural (50.25%) was obtained combined with tetrahedral and octahedral framework aluminum active sites in GBL, while high selectivity of HMF (83.3%) was achieved in presence of single tetrahedral framework aluminum over H beta in NMP.

Reference of 19982-07-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 19982-07-1 is helpful to your research.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of N-(3,5-Dimethyladamantan-1-yl)acetamide19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, SMILES is CC(NC12CC3(C)CC(C2)(C)CC(C3)C1)=O, belongs to amides-buliding-blocks compound. In a article, author is Berberich, Oliver, introduce new discover of the category.

Calmodulin regulates Ca(v)3 T-type channels at their gating brake

Calcium (Ca(v)1 and Ca(v)2) and sodium channels possess homologous CaM-binding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a universal calcium sensor. Ca(v)3 T-type channels, which serve as pacemakers of the mammalian brain and heart, lack a C-terminal IQ motif. We illustrate that T-type channels associate with CaM using co-immunoprecipitation experiments and single particle cryo-electron microscopy. We demonstrate that protostome invertebrate (LCa(v)3) and human Ca(v)3.1, Ca(v)3.2, and Ca(v)3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels. Isothermal titration calorimetry results revealed that the gating brake and CaM bind each other with high-nanomolar affinity. We show that the gating brake assumes a helical conformation upon binding CaM, with associated conformational changes to both CaM lobes as indicated by amide chemical shifts of the amino acids of CaM in H-1-N-15 HSQC NMR spectra. Intact Ca2+-binding sites on CaM and an intact gating brake sequence (first 39 amino acids of the I-II linker) were required in Ca(v)3.2 channels to prevent the runaway gating phenotype, a hyperpolarizing shift in voltage sensitivities and faster gating kinetics. We conclude that the presence of high-nanomolar affinity binding sites for CaM at its universal gating brake and its unique form of regulation via the tuning of the voltage range of activity could influence the participation of Ca(v)3 T-type channels in heart and brain rhythms. Our findings may have implications for arrhythmia disorders arising from mutations in the gating brake or CaM.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 19982-07-1. Quality Control of N-(3,5-Dimethyladamantan-1-yl)acetamide.

Electric Literature of 19982-07-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.

l-Acetamido-3,5-dimethyladamantane (44 gm) as obtained in example 1, sodium hydroxide and diethylene glycol are added, and heated to reflux. Then, the contents were maintained for 6 hours at reflux and water (1 175 ml) was added under stirring. The reaction mass was cooled to below 20 C and then added methylene chloride (750 ml), and stirred for 15 minutes at 20C. The layers were separated and the organic layer was distilled off completely under vacuum at below 45C to obtain a residue. The residue was dissolved in ethyl acetate (700 ml). Ethyl acetate hydrochloride (160 ml) was added to the reaction mass and stirred for 5 hours at 25 to 30C. The reaction mass was cooled to 0 to 5C and stirred for 1 hour at 0 to 5 C. The separated solid was filtered and dried at 50C for 2 hours to obtain 87 gm of memantine hydrochloride containing l-amino-3,5,7-trimethyladamantane hydrochloride and l-amino-3-methyladamantane hydrochloride impurity.Memantine hydrochloride: 99.3%;The combined contents of l-amino-3,5,7-trimethyladamantane hydrochloride and 1- amino-3-methyladamantane hydrochloride impurity: 0.5%.

The chemical industry reduces the impact on the environment during synthesis N-(3,5-Dimethyladamantan-1-yl)acetamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi; WO2011/125062; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

19982-07-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.

Add 38.9g of Compound A to a 500ml three-necked flask,The reaction bottle was placed in an ice-water bath, then 21.4ml of nitric acid was added, and then 270.4ml of sulfuric acid was slowly added, and the addition was completed in about 40 minutes. After the addition, the temperature was slowly raised to room temperature and the reaction was completed for 4h. Post-treatment: Pour the reaction solution into 1L of ice water, stir the reaction thoroughly after quenching, add dichloromethane (200ml ¡Á 5) for extraction, wash with saturated sodium chloride solution 300ml, dry with anhydrous magnesium sulfate, filter, the filtrate is reduced at 45 Autoclaved,The residue was recrystallized from ethyl acetate / n-hexane (V / V = 100ml / 100ml) at 0 C.After filtration, the filter cake was dried under vacuum (-0.09MPa) at 40 C for 3h to obtain 14.5g of product compound D. Yield: 34.8% and GC purity: 99.1%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Chongqing Zhien Pharmaceutical Co., Ltd.; Chongqing Liujiang Pharmaceutical Technology Co., Ltd.; Mu Xiang; Zhang Wei; Han Juan; Li Yufang; Deng Xianglin; Xiang Yong; (9 pag.)CN110938006; (2020); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

19982-07-1, Adding some certain compound to certain chemical reactions, such as: 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19982-07-1.

l-Acetamido-3,5-dimethyl adamantane (40.0 g) was added to reaction vessel followed by addition of sodium hydroxide (57.80 g) and DEG (200 mL) at 25-300C. The reaction mixture was stirred and then heated at 155-1700C and heating was maintained for 10 Hrs. The reaction mixture was cooled to 80-850C and water (1600 mL) was added within 1 Hr. Reaction mixture was stirred for 30 minutes and toluene (500 mL) was added to the reaction mixture and further stirred for 1 Hr. After stirring the layers were settled for 30 minutes and then separated out. The organic (Toluene) layer was kept and to the aqueous layer, toluene (300 mL) was added and stirred for 1 Hr and after stirring layers were settled and separated out. Total toluene layers were collected and water (500 mL) was added to it and stirred for 1 Hr at 25-300C. After stirring the layers were settled for 30 minutes and then separated out. Organic (toluene) layer was dried over anhydrous sodium sulfate and wash the bed with toluene (50 mL)and then toluene was distilled under reduced pressure below 600C to afford the title compound Memantine Base.; Example 3 (b): Preparation of Memantine Base (One pot synthesis) l~Bromo-3,5-dimethyl adamantane (60.0 g) was added to reaction vessel followed addition of acetamide (87.42 g) the reaction mixture was stirred and heated at 130-1400C for 3 to 5 Hrs. The reaction mixture was cooled up to 80- 850C and then toluene (300 mL) was added to reaction mixture and stirred for 1 Hr. The reaction mixture was treated with water (600 mL) and stirred for lhr. The reaction mixture was filtered and washed with toluene. The organic layer was separated and toluene was distilled out at temperature range 105-130C.Cool to 105-1150C and the reaction mass was again treated with DEG(270 mL) at 105-1150C maintaing 105-1150C for 2 hrs. Again distill out toluene at 130-140C.Cool at 105-1150C and add sodium hydroxide (78 g) was added at 105-1150C. The reaction mixture was stirred and then heated at 155-1700C and heating was maintained for 10 Hrs. The reaction mixture was cooled to 80-850C and water (200 mL) was added within 1 Hr. Reaction mixture was stirred for 30 minutes and toluene (400 mL) was added to the reaction mixture and further stirred for 1 Hr. After stirring the layers were settled for 30 minutes and then separated out. The organic (Toluene) layer was kept and to the aqueous layer, toluene (50 mL) was added and stirred for 1 Hr and after stirring layers were settled and separated out. Total toluene layers were collected and water (500 ml) was added to it and stirred for 1 Hr at 25-300C. After stirring the layers were settled for 30 minutes and then separated out to afford the title compound Memantine Base.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19982-07-1.

Reference:
Patent; CADILA HEALTHCARE LIMITED; WO2008/62472; (2008); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics