Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, A new synthetic method of this compound is introduced below., Product Details of 19982-07-1
Example 5: Memantine hydrochloride synthesis; 486g (600 ml) of n-butanol, 150 g of l-acetamido-3,5-dimethyladamantane and241 g of 89.9% potassium hydroxide are added to a 2-liter reactor equipped with a condenser, a mechanical stirrer, and a thermometer at 20-250C under nitrogen. After addition, the internal temperature rises to 40-450C without external cooling. The resulting suspension is heated to 128-132C over 20-30min and a solution is obtained. After lOhrs at 128-132C (no reflux), the reaction is complete (unreacted l-acetamido-3,5- dimethyladamantane less than 1%).After cooling to 45-500C, water (450ml) is added to form a biphasic system. After stirring (5min) and standing (15min) at 20-250C, the phases are separated. The aqueous phase is discarded and water (225ml) is added to organic phase to form a biphasic system and pH is brought to 10.5-11 with 37% hydrochloric acid (1Og). After stirring (5min) and standing (15min) at 20-250C, the phases are separated. Water (225ml) is added to the organic phase to form a biphasic system and after stirring (5min) and standing (15min) at 20-250C, the phases are separated. To the organic phase, 37% hydrochloric acid (66,9g) is added and the solution is filtered on paper filter. The obtained solution is concentrated under vacuum until a residual volume of 360 ml is obtained (a semisolid but well stirrable mixture) and internal temperature is 5O-55C. At this point, after cooling to 45-500C, ethyl acetate (750ml) is added. The obtained suspension is cooled to 0+/-3C and after 3hrs it is filtered and solid washed three times with ethyl acetate (90ml each). Wet white solid is dried under vacuum at 55-600C for 15 hrs. Dry weight: 138.7g, Yield: 95%, Purity: 99.97% by GC.
The synthetic route of 19982-07-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L.; TEVA PHARMACEUTICALS USA, INC.; WO2007/126886; (2007); A1;,
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