Category: 19982-07-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, A new synthetic method of this compound is introduced below., Product Details of 19982-07-1

Example 5: Memantine hydrochloride synthesis; 486g (600 ml) of n-butanol, 150 g of l-acetamido-3,5-dimethyladamantane and241 g of 89.9% potassium hydroxide are added to a 2-liter reactor equipped with a condenser, a mechanical stirrer, and a thermometer at 20-250C under nitrogen. After addition, the internal temperature rises to 40-450C without external cooling. The resulting suspension is heated to 128-132C over 20-30min and a solution is obtained. After lOhrs at 128-132C (no reflux), the reaction is complete (unreacted l-acetamido-3,5- dimethyladamantane less than 1%).After cooling to 45-500C, water (450ml) is added to form a biphasic system. After stirring (5min) and standing (15min) at 20-250C, the phases are separated. The aqueous phase is discarded and water (225ml) is added to organic phase to form a biphasic system and pH is brought to 10.5-11 with 37% hydrochloric acid (1Og). After stirring (5min) and standing (15min) at 20-250C, the phases are separated. Water (225ml) is added to the organic phase to form a biphasic system and after stirring (5min) and standing (15min) at 20-250C, the phases are separated. To the organic phase, 37% hydrochloric acid (66,9g) is added and the solution is filtered on paper filter. The obtained solution is concentrated under vacuum until a residual volume of 360 ml is obtained (a semisolid but well stirrable mixture) and internal temperature is 5O-55C. At this point, after cooling to 45-500C, ethyl acetate (750ml) is added. The obtained suspension is cooled to 0+/-3C and after 3hrs it is filtered and solid washed three times with ethyl acetate (90ml each). Wet white solid is dried under vacuum at 55-600C for 15 hrs. Dry weight: 138.7g, Yield: 95%, Purity: 99.97% by GC.

The synthetic route of 19982-07-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L.; TEVA PHARMACEUTICALS USA, INC.; WO2007/126886; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19982-07-1, name: N-(3,5-Dimethyladamantan-1-yl)acetamide

[0063] 1.00 g (5.50 mmol) of 3,5-dimethyl-1-adamantanol, 0.46 g (11.1 mmol) of acetonitrile, and 9.61 g of mesitylenewere added to a test tube having an outer diameter of 30 mm to obtain a mixed solution. Then, 1.12 g (11.1 mmol) of97% concentrated sulfuric acid was dropped into the mixed solution in the test tube to obtain a reaction solution. Theobtained reaction solution was stirred at 30C for 3 hours to continue the reaction. Then, 6.09 g of water was added tothe reaction solution to stop the reaction, and an aqueous phase was removed by washing from the reaction solution toobtain a mesitylene solution containing 1-acetamido-3,5-dimethyladamantane (reaction yield: 80.4%). Then, 0.71 g ofsodium hydrate (NaOH) and 9.61 g of 1-hexanol were added to the obtained solution to obtain a reaction solution. The obtained reaction solution was stirred at 130C for 18 hours to hydrolyze 1-acetamido-3,5-dimethyladamantane. Then,in the reaction solution, the generation of memantine was confirmed by GC (reaction yield: 96.2%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; SHIMO, Tetsuya; EP2949643; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 19982-07-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, SMILES is CC(NC12CC3(C)CC(C2)(C)CC(C3)C1)=O, belongs to amides-buliding-blocks compound. In a article, author is Alniss, Hasan Y., introduce new discover of the category.

In this study, a viscoelastic surfactant (VES), named VES-Q, with erucyl amide tails and cyclodextrin was successfully synthesized, and the phase behavior of aqueous VES solutions at different salt concentrations was observed. In addition, the size of the molecules under different salt types was measured using dynamic light scattering. The viscosity of VES-Q in salt solution corresponds to the molecular size of the surfactant was found. Due to the high salinity tolerance of VES-Q to common formation salts, we used formation water from West Sichuan and seawater the Gulf of Mexico to allocate VES-Q to two clean fracturing fluids, namely, fluid 1 and fluid 2, with a concentration of 2%. Rheological properties under high-temperature reservoir conditions were simulated. The clean fracturing fluid was prepared by the VES-Q method, and its performance met the requirements of hydraulic fracturing operations.

Reference of 19982-07-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 19982-07-1.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Electric Literature of 19982-07-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, SMILES is CC(NC12CC3(C)CC(C2)(C)CC(C3)C1)=O, belongs to amides-buliding-blocks compound. In a article, author is Farashi, Zahra, introduce new discover of the category.

Herein we report two different reactivity modes of lithium(aryl) (boryl)amide, 4, when it is reacted with chlorosilanes such as SiCl4 and MeSiHCl2, and chlorophosphine, Ph2PCl. Thus, the reaction of lithium(aryl)(boryl)amide, 4, with MeSiHCl2 leads exclusively to an N-substitution product, 6. On the other hand, the reaction of 4 with SiCl4 and Ph2PCl proceeds completely differently affording exclusively p-aryl-C-substitution products, 5 and 7, respectively.

Electric Literature of 19982-07-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 19982-07-1.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, molecular formula is C14H23NO. In an article, author is Kim, Min Jee,once mentioned of 19982-07-1, Product Details of 19982-07-1.

Surgical removal of the primary tumor in solid cancer is an essential component of the treatment. However, the perioperative period can paradoxically lead to an increased risk of cancer recurrence. A bimodal dynamics for early-stage breast cancer recurrence suggests a tumor dormancy-based model with a mastectomy-driven acceleration of the metastatic process and a crucial role of the immunosuppressive state during the perioperative period. Recent evidence suggests that anesthesia could also influence the progress of the disease. Local anesthetics (LAs) have long been used for their properties to block nociceptive input. They also exert anti-inflammatory capacities by modulating the liberation or signal propagation of inflammatory mediators. Interestingly, LAs can reduce viability and proliferation of many cancer cells in vitro as well. Additionally, retrospective clinical trials have suggested that regional anesthesia for cancer surgery (either with or without general anesthesia) might reduce the risk of recurrence. Lidocaine, a LA, which can be administered intravenously, is widely used in clinical practice for multimodal analgesia. It is associated with a morphine-sparing effect, reduced pain scores, and in major surgery probably also with a reduced incidence of postoperative ileus and length of hospital stay. Systemic delivery might therefore be efficient to target residual disease or reach cells able to form micrometastasis. Moreover, an in vitro study has shown that lidocaine could enhance the activity of natural killer (NK) cells. Due to their ability to recognize and kill tumor cells without the requirement of prior antigen exposure, NKs are the main actor of the innate immune system. However, several perioperative factors can reduce NK activity, such as stress, pain, opioids, or general anesthetics. Intravenous lidocaine as part of the perioperative anesthesia regimen would be of major interest for clinicians, as it might bear the potential to reduce the risk of cancer recurrence or progression patients undergoing cancer surgery. As a well-known pharmaceutical agent, lidocaine might therefore be a promising candidate for oncological drug repurposing. We urgently need clinical randomized trials assessing the protective effect of lidocaine on NKs function and against recurrence after cancer surgery to achieve a proof of concept.

Interested yet? Keep reading other articles of 19982-07-1, you can contact me at any time and look forward to more communication. Product Details of 19982-07-1.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, molecular formula is C14H23NO, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Kruk-Slomka, Marta, once mentioned the new application about 19982-07-1, Safety of N-(3,5-Dimethyladamantan-1-yl)acetamide.

Through a facile structural modification on the natural bioactive ingredient 18 beta-glycyrrhetinic acid(GA), a series of novel GA hydrazide or amide derivatives was obtained, and their final molecular frameworks were characterized by NMR and HRMS analysis. Antibacterial bioassays revealed that some of the GA hydrazide or amide derivatives were able to suppress the growth of three tested plant pathogens. Particularly, compound 3c exhibited excellent in vitro activity against Xanthomonas oryzae pv. Oryzae (Xoo), Pseudomonas syringae pv. actinidiae(Psa), and Xanthomonas axonopodis pv. citri(Xac), providing the EC50 values of 5.89, 16.1, and 3.64 mu g/mL, respectively. The data were better than those of the positive controls thiodiazole copper(92.7, 77.8, and 89.9 mu g/mL, respectively) and bismerthiazol(31.1, 125.6, and 77.4 mu g/mL, respectively). In addition, in vivo experiments suggested that, compared with thiodiazole copper(41.93% and 39.73%, respectively), compound 3c exerted prominently curative and protective activities against rice bacterial leaf blight at 200 mu g/mL with the control effects of 52.36% and 51.40%, respectively. Given these obtained results, GA hydrazide or amide derivatives could serve as the feasible leads for exploring highly bioactive substrates.

If you’re interested in learning more about 19982-07-1. The above is the message from the blog manager. Safety of N-(3,5-Dimethyladamantan-1-yl)acetamide.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide. In a document, author is Oubelkacem, Yacine, introducing its new discovery. Recommanded Product: 19982-07-1.

A new bis-(3-hydroxy-4-pyridinone) ligand (NTA(PrHP)(2)), derived from nitrilotriacetic acid (NTA), was synthesized and evaluated for its selective solution metal complexation capacity as well as its in vivo sequestering power for hard metal cations. After the study of its acid-base properties and determination of the protonation constants, the binding ability of NTA(PrHP)(2) towards divalent (Ca2+, Cu2+, Zn2+) and trivalent (Al3+, Fe3+) metal cations was investigated by means of UV-Vis spectrophotometric, potentiometric and H-1 NMR measurements. The determined speciation models consist of MpLqHr species with different stoichiometry. The obtained stability constants for the ML species follow the trend: Fe3+ > Al3+ > Cu2+ > Zn2+ > Ca2+. Furthermore, the sequestering ability of the ligand towards these metal cations was investigated by the determination of the pL(0.5) and pM parameters calculated at different pHs and pH = 7.4, respectively. High pL(0.5) values were obtained with significant variation of the sequestering ability with the investigated pH range. Analysis of the pM values at pH = 7.4 showed that the metal-ligand affinity follows the trend: Fe3+ > Al3+ > Cu2+ > Zn2+ > Ca2+. Finally, in vivo assays were performed to verify the efficacy of NTA(PrHP)(2) as sequestering agent towards trivalent metal cations, when administered to mice preloaded with the radiotracer Ga-67-citrate. (C) 2018 Published by Elsevier B.V.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 19982-07-1 help many people in the next few years. Recommanded Product: 19982-07-1.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In an article, author is Yadav, Amit Kumar, once mentioned the application of 19982-07-1, HPLC of Formula: https://www.ambeed.com/products/19982-07-1.html, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, molecular formula is C14H23NO, molecular weight is 221.3385, MDL number is MFCD06656139, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.

The present study reports one of the first attempts on the design and development of an enzymaticbiodegradable theranostic fluorescence resonance energy transfer (FRET) probe constructed on L-amino acid polymer nanoassemblies and demonstrates the proof-of-concept in live cell bioimaging. L-Aspartic acid was converted into amide or carbamate pendants containing bis-carboxylic acid ester monomers, and they were subjected to melt polymerization along with commercial diols to produce amphiphilic aliphatic polyesters. Nanoparticles of size <200 nm were obtained because of selfassembly of these amphiphilic polyesters in an aqueous medium. These nanoparticles exhibited excellent encapsulation capability for green-fluorescent anti-inflammatory drug curcumin (CUR) and highly luminescent red-fluorophore Nile red (NR) to yield a CUR-NR theranostic FRET probe. Detailed photophysical studies were carried out to demonstrate photoexcitation energy transfer from CUR to NR for the occurrence of the FRET phenomena. The theranostic FRET probe was found to be very stable at extracellular environment and underwent biodegradation at the intracellular regions for delivery of the loaded cargoes. As a result, the theranostic FRET probe functioned as turn-on at the extracellular level and became turnoff at the intracellular level under lysosomal enzyme-responsiveness. The polymer nanoparticle was nontoxic to cells, whereas its CUR encapsulated nanoparticle showed relatively good cytotoxicity in breast cancer cell lines. Live cell confocal microscopy studies using lysotracker staining confirmed the colocalization of CUR as well as NR within the polymer nanoparticles in the lysosomes for enzymatic-biodegradation. Selective photoexcitation experiments in the confocal microscope were carried out to study the FRET probe action in cancer cells. Time-dependent FRET imaging directly supported the occurrence of FRET at the intracellular level and enabled the real-time drug release studies. The present approach opens natural resource-based biodegradable theranostic FRET probes for bioimaging application. If you are interested in 19982-07-1, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/19982-07-1.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, molecular formula is C14H23NO, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Gamper, Howard, once mentioned the new application about 19982-07-1, Computed Properties of https://www.ambeed.com/products/19982-07-1.html.

Rigid ladder polymers represent a unique polymer architecture but have limited synthetic accessibility and structural diversity. Using catalytic arene-norbornene annulation (CANAL) polymerization, we synthesized ladder polymers consisting of rigid and kinked norbornyl benzocyclobutene backbones and bearing various functional groups, such as alcohol, amine, ester, carbamate, amide, benzyl bromide, azide, and heterocycles. The incorporation of functional groups was achieved by either copolymerization of functionalized ladder-type dinorbornenes or postpolymerization functionalization. Functionalization of ladder polymers allows modification of their solubility, compatibility, and other properties, expanding their utilities. These ladder polymers remain microporous and highly glassy, which are desirable for separation and high-temperature applications.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 19982-07-1. The above is the message from the blog manager. Computed Properties of https://www.ambeed.com/products/19982-07-1.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, molecular formula is C14H23NO. In an article, author is Wang, Zhenggong,once mentioned of 19982-07-1, Recommanded Product: N-(3,5-Dimethyladamantan-1-yl)acetamide.

An efficient protocol for the straightforward synthesis of amides from readily available carboxylic acids and tetraalkylthiuram disulfides is presented. The reaction proceeds through direct cross-coupling reactions promoted by catalytic amount of PPh3 in DMSO. This protocol is compatible with a wide variety of electron-donating and -withdrawing acids, which shows its practical synthetic value in organic synthesis.

Interested yet? Keep reading other articles of 19982-07-1, you can contact me at any time and look forward to more communication. Recommanded Product: N-(3,5-Dimethyladamantan-1-yl)acetamide.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics