Category: 198211-38-0

Related Products of 198211-38-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 198211-38-0, name is tert-Butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 21 Preparation of (4S,4aS,5aR,12aS)-9-((6-amino-3-azabicyclo[3.1.0]hexan-3-yl)methyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,1′-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (the hydrochloride of Compound 26) In a 25 mL single-neck flask, Compound A (1 g) and tert-butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate (1 g) were dissolved in 5 mL of DMF, and reacted at room temperature for 0.5 h, 1.4 g of sodium triacetoxy borohydride was added slowly, and further reacted for 0.5 h. Then the reaction solution was mixed with 10 g of C18 fillers, packed into a column, separated by a quick preparative chromatography of ISCO (acetonitrile:water=1-10:100), collected the fraction which was confirmed by thin layer chromatography (TLC) to contain Compound 26. 10 mL of concentrated hydrochloric acid was added and stirred at room temperature for 0.5 h. After enrichment, the mixture was concentrated and freeze-dried to give hydrochloride of Compound 26 (58 mg, pale yellow powder). 1H NMR (D2O, 400 MHz) delta: 7.93 (s, 1H), 4.50 (m, 3H), 3.97 (s, 1H), 3.67 (br, 2H), 3.18 (s, 6H), 2.86-3.09 (m, 10H), 2.49 (t, 1H), 2.32 (s, 2H), 2.17 (d, 2H), 1.58 (m, 1H)

The synthetic route of tert-Butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KBP BIOSCIENCES CO., LTD.; Zhang, Hui; Dong, Yanyan; US2014/179638; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 198211-38-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 198211-38-0, name is tert-Butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate, This compound has unique chemical properties. The synthetic route is as follows.

Example 3; Synthesis of 6-amino-3-azabicyclo[3.1.0]hexane-3-N-(4-fluorophenyl)carboxamide (pTSA salt)Step a: Synthesis of tert-butyl (3-{[(4-fluorophenyl)amino]carbonyl}-3-azabicyclo[3.1.0]hex-6-yl)carbamateTo a solution of tert-butyl 3-azabicyclo[3.1.0]hex-6-ylcarbamate (0.500 g, 2.50 mmol) in dichloromethane (10.0 mL) at 0 C., was added dropwise a solution of 4-fluorophenyl isocyanate (0.34 mL, 3.0 mmol) in dichloromethane (5.0 mL) and stirred at 0 C. for about 3 hours. The reaction mixture was partitioned between water (10.0 mL) and dichloromethane (20.0 mL). The organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure to yield the title product, which was used directly in the next step.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Sattigeri, Jitendra A.; Andappan, Murugaiah M.S.; Kishore, Kaushal; Sethi, Sachin; Kandalkar, Sachin Ramesh; Pal, Chanchal Kumar; Mahajan, Dipak C.; Ahmed, Shahadat; Parkale, Santhosh Sadashiv; Srinivasan, T.; Sharma, Lalima; Bansal, Vinay S.; Chugh, Anita; Davis, Joseph Alexanand; US2008/300251; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 198211-38-0, name is tert-Butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate, molecular formula is C10H18N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of tert-Butyl 3-azabicyclo[3.1.0]hexan-6-ylcarbamate

General procedure: Intermediate C17.ii (130 mg) and K2C03 (69 mg) were suspended with DMF. 6-(Boc-amino)-3-azabicyclo[3. 1.0]hexane (81 mg; commercial) was added portionwise and themixture was stirred at rt for 1 day. The mixture was concentrated under reduced pressure and the residue was portioned between EA and water. The aq. layer was extracted with EA and the combined org. layers were washed with water and brine, dried over Mg504 and concentrated under reduced pressure. The title compound was obtained, after purificationby CC (Combiflash; Hept/EA 0:1 to 1:0), as a yellow oil (108 mg; 62% yield). M53 (ESI, mlz): 457.10 [M+H+]; tR = 0.73 mm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 198211-38-0, its application will become more common.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CREN, Sylvaine; FRIEDLI, Astrid; RUEEDI, Georg; ZUMBRUNN, Cornelia; (200 pag.)WO2016/59097; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics