Category: 19311-91-2

An efficient synthesis of 3-cyano-1(3H)-isobenzofuranones was written by Okazaki, Kousuke;Nomura, Keiichi;Yoshii, Eiichi. And the article was included in Synthetic Communications in 1987.Formula: C11H15NO2 This article mentions the following:

Salicylamides I (R¹ = H, OMe, OCH₂OMe; R² = H, OMe, F; R³ = H, OMe; R⁴ = H, OMe, OCH₂OMe, F) were converted to phthalides II in two steps. I were treated with MeSiCN, KCN, and 18-crown-6 to yield cyanohydrin derivatives III, and the latter were kept in HOAc to give II. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Salicylamide in urine after intake of acetylsalicylic acid due to degradation of salicylic acid conjugates was written by Besserer, Kurt;Tiess, Detlef;Kala, Maria. And the article was included in Z Zagadnien Nauk Sadowych in 2000.Recommanded Product: N,N-Diethylsalicylamide This article mentions the following:

In addition to the well-known acetylsalicylic acid metabolites, salicylamide (SA) was detected in urine from healthy persons after intake of acetylsalicylic acid. SA was found in the Et₂O extracts of urine after alkalinization by ammonia solution SA was identified by gas chromatog.-mass spectrometry. Further examination showed that SA was present in urine only after alkalinization by ammonia solution and not after alkalinization by NaHCO₃ or Na₂CO₃. When dimethyl-, diethyl- or dibutylamine was used for the alkalinization of the urine, the corresponding salicylic acid dialkylamides were detected. Further anal. led to the conclusion that ester-type salicylic acid glucuronide conjugates undergo degradation by hydrolytic amination to form the corresponding amides. This gives the possibility of a specific demonstration of the presence of ester-type glucuronide conjugates. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Regioselective synthesis of C3 alkylated and arylated benzothiophenes was written by Shrives, Harry J.;Fernandez-Salas, Jose A.;Hedtke, Christin;Pulis, Alexander P.;Procter, David J.. And the article was included in Nature Communications in 2017.Synthetic Route of C11H15NO2 This article mentions the following:

The method for completely regioselective, metal-free C3 C-H functionalization of benzothiophenes e.g., I that utilizes synthetically unexplored benzothiophene S-oxides II (R¹ = H, 5-NO₂, 6-Br, etc.; R² = H, CO₂CH₃, CN, etc.), readily available from straightforward oxidation of benzothiophenes such as 5-bromobenzo[b]thiophene, 2-phenylbenzo[b]thiophene, 2-methylbenzo[b]thiophene, etc. and phenols such as p-cresol, 4-iodophenol, 4-nitrophenol, etc./propargyl silanes such as trimethyl(allyl)silane, trimethyl(2-bromoallyl)silane, 2-((trimethylsilyl)methyl)allyl acetate, etc. and allyl silanes such as propargyl silane, hex-1-yne-1,3-diylbis(trimethylsilane), hept-2-yn-1-yltrimethylsilane, etc. was described. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

From Carbamate to Chalcone: Consecutive Anionic Fries Rearrangement, Anionic Si → C Alkyl Rearrangement, and Claisen-Schmidt Condensation was written by Kumar, Singam Naveen;Bavikar, Suhas Ravindra;Pavan Kumar, Chebolu Naga Sesha Sai;Yu, Isaac Furay;Chein, Rong-Jie. And the article was included in Organic Letters in 2018.Electric Literature of C11H15NO2 This article mentions the following:

A highly efficient one-pot procedure was developed for the synthesis of various 2′-hydroxychalcones from Ph diethylcarbamate, featuring consecutive Snieckus-Fries rearrangement, anionic Si → C alkyl rearrangement, and Claisen-Schmidt condensation in a single operation. The applicability of this protocol was demonstrated by the highly efficient synthesis of the anti-inflammatory natural product lonchocarpin. The mechanism insight is also provided. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Electric Literature of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics