Category: 19311-91-2

Reaction of phenol with diethylcarbamoyl chloride in the presence of Lewis acids was written by Isakova, A. P.;Naumov, Yu. A.;Nikeryasova, S. V.;Stepanova, A. A.. And the article was included in Zhurnal Organicheskoi Khimii in 1982.Related Products of 19311-91-2 This article mentions the following:

In the presence of SnCl₄ or AlCl₃, Et₂NCOCl reacted with PhOH to give Et₂NCO₂Ph, which at 175-80° underwent a Fries rearrangement to give I, II, and III, which were inactive as pesticides. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Related Products of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The Tetraethylphosphorodiamidate (OP(O)(NEt₂)₂) Directed Metalation Group (DMG). Directed ortho and Lateral Metalation and the Phospha Anionic Fries Rearrangement was written by Alessi, Manlio;Patel, Jignesh J.;Zumbansen, Kristina;Snieckus, Victor. And the article was included in Organic Letters in 2020.Application of 19311-91-2 This article mentions the following:

We report on the tetraethylphosphorodiamidate (-OP(O)(NEt₂)₂) group as an effective directed metalation group (DMG). Directed ortho-lithiation-electrophile quench of ArOP(O)(NEt₂)₂ (1a–e; Ar = substituted Ph, 2-naphthyl) provides a general synthesis of ortho-substituted aryl and naphthyl phosphorodiamidates. We also describe the phospha anionic ortho-Fries (AoF) rearrangement of the phosphorodiamidates 1a,b, giving phosphonates 3-R-2-[P(O)(NEt₂)₂]C₆H₃OH its vinylogous counterpart to the ortho-tolyl phosphorodiamidates. Intermol. competition experiments demonstrate the approx. equal DMG strength of the -OP(O)(NEt₂)₂ and the most powerful OCONEt₂ groups. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anionic ortho-Fries rearrangement, a facile route to arenol-based Mannich bases was written by Assimomytis, Nikos;Sariyannis, Yiannis;Stavropoulos, Georgios;Tsoungas, Petros G.;Varvounis, George;Cordopatis, Paul. And the article was included in Synlett in 2009.Safety of N,N-Diethylsalicylamide This article mentions the following:

Phenol and 1-naphthol-based carbamates undergo the anionic ortho-Fries rearrangement to their corresponding amides. Bulky substitution at position 8 of 1-naphthol-based carbamates makes the rearrangement an exclusive reaction, even at -90°, under a variety of conditions. The amides can be efficiently reduced to the corresponding Mannich bases. A novel route to 7-[(dialkylamino)methyl]-8-hydroxy-1-naphthaldehydes is presented. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Safety of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Aminoborohydrides. 3. A facile reduction of tertiary amides to the corresponding amines and alcohols in high purity using lithium aminoborohydrides. Sterically controlled selective carbon-nitrogen or carbon-oxygen bond cleavage was written by Fisher, Gary B.;Fuller, Joseph C.;Harrison, John;Goralski, Christian T.;Singaram, Bakthan. And the article was included in Tetrahedron Letters in 1993.Formula: C11H15NO2 This article mentions the following:

Lithium aminoborohydrides (LiABH₃), obtained by the reaction of n-BuLi with amine-boranes, are powerful reducing agents for the reduction of tertiary amides to the corresponding amines or alcs. Lithium pyrrolidinoborohydride and lithium diisopropylaminoborohydride reduce both aliphatic and aromatic tertiary amides to give either the corresponding alc. or amine, depending on the steric requirement of the tertiary amide and the LiABH₃ used. The yields of amines and alcs. from this procedure range from very good to essentially quant. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

I₂-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones was written by Chen, Kaili;Gao, Biao;Shang, Yanguo;Du, Jianyao;Gu, Qinlan;Wang, Jinxin. And the article was included in Organic & Biomolecular Chemistry in 2017.Computed Properties of C11H15NO2 This article mentions the following:

An efficient and applicable I₂-catalyzed intramol. dehydrogenative C-O/C-N coupling reaction via activating the C-H bond adjacent to the N atom has been developed to provide dozens of substituted benzoxazinones I (R¹ = H, 8-OMe, 6-F, etc.; R² = Me, Et, Bn, etc.; R³ = C₆H₅, 4-H₃CC₆H₄, 4-FC₆H₄, etc.; X = O, S) (31 examples) and quinazolinones, e.g. II (5 examples) in good to excellent yields (up to 98%). This one-pot methodol. has significant advantages, including a metal-free process, broad substrate scope, high atom economy, and simple operation. This strategy goes through an iminium intermediate followed by nucleophilic attack to provide the desired products. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antipyretic activity of new salicylate and gentisate derivatives was written by Preziosi, P.. And the article was included in Bollettino – Societa Italiana di Biologia Sperimentale in 1953.Synthetic Route of C11H15NO2 This article mentions the following:

Salicylic hydrazide, acetylsalicylic hydrazide, N,N-diethylsalicylamide, gentisamide, ο-ethoxybenzamide, salicylamide, diacetylgentisic acid, and ο-(diethylaminoethoxy)benzamide were tested for antipyretic activity on rabbits. Fever was induced by intravenous injection of pyrogen and the material being tested was introduced peritoneally. Results show decreasing activity of the materials in the order listed. All of the compounds with the exception of the last 2 produced a temperature drop within 3-4 hours. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The analgesic properties of some substituted salicylamide derivatives was written by Carron, M.;Tabart, J.;Jullien, Mrs.. And the article was included in Therapie in 1952.Related Products of 19311-91-2 This article mentions the following:

Derivatives of salicylamide (I) were prepared; they had general formulas C₆H₄OH.CONRR’ or C₆H₄CONH₂. OR”. Their lethal doses (per os) and analgesic effects were determined by the Armour and Smith method (J. Pharm. Exptl. Therap. 72, 74, 1941). Introduction of hydrosol. groups, methoxylation, and acetylation of the phenolic function lowered the analgesic power; ethoxylation of the same increased it. Substitution of amide H by alkyls activated the analgesic effect from Et to iso-Pr, but Me and Bu derivatives had low activities. Hydrosol. functions introduced on the amide did not modify the effect of the products. Joining 2 I mols by a C₃ chain increased its effect, but a C₁ or C₂ linkage lowered the activity of the compounds Min. analgesic doses and lethal doses of the most active derivatives compared with acetylsalicylic acid (II) were: I 0.3, 0.6; N-diethyl-I 0.15, 0.85; o-ethoxybenzamide 0.2, 0.7; o-acetylsalicylureide 0.2, 0.3; methylol-I 0.24, 0.85; N-isopropyl-I 0.25, 0.65; propylenebis-I 0.26, 0.95; and II 0.4, 0.83 g./kg. weight of mice. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Related Products of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper porphyrin-catalyzed C(sp²)-O bond construction via coupling phenols with formamides was written by Yang, Shuang;Chen, Xiao-Yan;Xiong, Ming-Feng;Zhang, Hao;Shi, Lei;Lin, Dong-Zi;Liu, Hai-Yang. And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2021.SDS of cas: 19311-91-2 This article mentions the following:

Copper porphyrin-catalyzed construction of C(sp²)-O bond via coupling formamides with phenols was achieved firstly. A broad range of substrates afforded various carbamates R¹R²NC(O)OR [R¹ = 4-FC₆H₄, 3-CHOC₆H₄, 2-F₃CC₆H₄, etc.; R¹ = Me, Et; R² = Me, Et; R¹R² = CH₂CH₂OCH₂CH₂] in moderate to good yields with good functional group tolerance at low catalyst loading. Intermol. competing kinetic isotope effect experiment indicated that the generation of formamide radical was the rate-determining step of current cross-dehydrogenative coupling (CDC) reaction. The research extended the application of metalloporphyrin in CDC reaction. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2SDS of cas: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil was written by Bouteiller, Cedric;Becerril-Ortega, Javier;Marchand, Patrice;Nicole, Olivier;Barre, Louisa;Buisson, Alain;Perrio, Cecile. And the article was included in Organic & Biomolecular Chemistry in 2010.Product Details of 19311-91-2 This article mentions the following:

An operationally simple and concise synthesis of anilinoethanolamines, as NMDA NR2B receptor antagonist ifenprodil analogs, was developed via a copper-catalyzed amination of the corresponding bromoarene. Coupling was achieved with linear primary alkylamines, α,ω-diamines, hexanolamine and benzophenone imine, as well as with aqueous ammonia, in good yields using CuI and N,N-diethylsalicylamide, 2,4-pentadione or 2-acetylcyclohexanone as catalytic systems. Amination with ethylene diamine was efficient even in the absence of an additive ligand, whereas no reaction occurred with ethanolamine whatever the conditions used. The anilinoethanolamines were evaluated as NR2B receptor antagonists in a functional inhibition assay. Aminoethylanilines displayed inhibition effects close to that of ifenprodil. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Product Details of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

α₁-Adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines was written by Hodson, Stephen J.;Bigham, Eric C.;Garrison, Deanna T.;Gobel, Michael J.;Irving, Paul E.;Liacos, James A.;Navas, Frank;Saussy, David L.;Sherman, Bryan W.;Speake, Jason D.;Bishop, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Recommanded Product: N,N-Diethylsalicylamide This article mentions the following:

Literature reports suggest that disruption of an interhelical salt bridge is critical for α₁-adrenoceptor activation, and the basic amine found in adrenergic receptor ligands is responsible for the disruption. Novel 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles are agonists of the cloned human α₁-adrenoceptors in vitro, and potent, selective α_1A-adrenoceptor agonists have been identified in this series. These imidazoles demonstrate similar potencies and α₁-subtype selectivities as the corresponding 2-substituted imidazolines. The extremely close SAR suggests that, in spite of the large difference in basicity, these imidazoles and imidazolines may establish the same interactions to activate α₁-adrenoceptors. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics