Category: 1888-91-1

Related Products of 1888-91-1,Some common heterocyclic compound, 1888-91-1, name is N-Acetylcaprolactam, molecular formula is C8H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The following five acetyl donating compounds were assessed at the outset: [0114] 1. N-acetoxysuccinimide [0115] 2. N-acetylsuccinimide [0116] 3. N-acetylcaprolactam [0117] 4. N,N,N,N-tetraacetylethyidiamine (TAED) [0118] 5. N,N,N-triacetylethylenediamine [0119] 6. Pentaacetylglucose [0120] Among these five compounds, only N-acetylcaprolactam is in the liquid state at ambient temperature. Some of the compounds are available on the market, although it was possible to carry out their synthesis by method available in the state of the art. [0121] From a preliminary assessment, it was observed that: [0122] Although poorly soluble in water, the first two compounds rapidly undergo perhydrolysis, once dispersed in a hydroalcoholic solution based on 3% w/w hydrogen peroxide; however, by being very reactive, they are highly sensitive to air moisture, so much so that their storage requires too severe conditions for use and above all for standard shipping. [0123] The third compound tends to separate at the bottom, once dispersed in a hydrophilic environment; however, it dissolves in the few moments after mixing owing to advancement of the perhydrolysis reaction and the solubilisation of the reaction by-products. This compound is also to be regarded as a medium fast rate N-acetylating agent and does not cause any particular problem, if suitably stored in tight-sealed vessels. [0124] The fourth compound is very well-known in the field of decontaminating, detergent and bleaching formulations and is a fast-rate acetylating agent even though it exhibits little solubility in water, particularly at ambient temperature and when the solution has a neutral-acidic pH. [0125] Finally, the fifth and the sixth compounds from a preliminary assessment were found to be weak acetylating agents and also poorly miscible with water.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Acetylcaprolactam, its application will become more common.

Reference:
Patent; Preto, Andrea; Tabasso, Paolo; US2004/2616; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 1888-91-1, A common heterocyclic compound, 1888-91-1, name is N-Acetylcaprolactam, molecular formula is C8H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Under an argon atmosphere, liquid NH3 (25 mL) was condensedin a two-neck round-bottom flask immersed in a dry ice coolingbath and equipped with a dry ice reflux condenser. Aldehyde(7.34 mmol) was added, and the resulting solution (or suspension)was stirred for 1 h. KMnO4 (7.34 mmol, 1.16 g) was added,the cooling bath was removed, and the reaction mixture wasstirred for another hour with gentle reflux of NH3. Na2SO3 (22.0mmol, 2.78 g) was added, the reflux condenser was removed,and the NH3 was allowed to evaporate spontaneously. The darkbrownresidue was treated with 6 M HCl (30 mL), and theresulting precipitate was filtered, washed with H2O (100 mL)and sat. aq NaHCO3 (20 mL). All products were recrystallizedfrom EtOH.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Antoniak, Damian; Sakowicz, Arkadiusz; Loska, Rafal; Makosza, Mieczyslaw; Synlett; vol. 25; 9; (2014);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

1888-91-1, The chemical industry reduces the impact on the environment during synthesis 1888-91-1, name is N-Acetylcaprolactam, I believe this compound will play a more active role in future production and life.

Further experiments, (4) and (5), were run in which N-Acetylcaprolactam wasused as the activator. In order to provide the equivalent number of labile acetyl groups to generate the peroxyacetic acid, the molar concentration of N-acetylcaprolactam was twice that of the TAED in Experiments (1) – (3) above. The results are given in Table 3 below. The results from Table 3, together with the results from column (3) of Table 1 are plotted in Figure 1. As can be seen from Figure 1, the presence of DTB results in a greater rate of generation of peroxyacetic acid.

The chemical industry reduces the impact on the environment during synthesis N-Acetylcaprolactam. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ANTEC INTERNATIONAL LIMITED; WO2006/16145; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics