Category: 18836-52-7

Alkaloids from Piper sarmentosum and Piper nigrum was written by Ee, G. C. L.;Lim, C. M.;Lim, C. K.;Rahmani, M.;Shaari, K.;Bong, C. F. J.. And the article was included in Natural Product Research in 2009.Application of 18836-52-7 The following contents are mentioned in the article:

Detailed chem. studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids. The roots of P. sarmentosum gave a new aromatic compound, 1-(nitrosoimino)methyl-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3′,4′-(methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid iso-Bu amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques. Cytotoxic activity screening of the plant extracts indicated some activity. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical constituents in Piper longum L. (I) was written by Wu, Xia;Yu, Zhibin;Ye, Yunhua;Zhou, Yawei. And the article was included in Zhongcaoyao in 2008.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The chem. constituents from in Piper longum L. were separated and purified by column chromatog. with silica gel, RP-C₁₈, Sephadex LH-20, and their structures were identified by ESI-MS, ¹H-NMR, and ¹³C-NMR. Ten compounds were obtained and identified as: piperine (I), Me piperate (II), guineensine (III), phenylpropionic acid (IV), pipercide (V), piperanine (VI), pellitorine (VII), (E)-4-[(2-methylpropyl)amino]-4-oxo-2-butenoic acid (VIII), pipernonaline (IX), and β-sitosterol (X), resp. Compound II, IV, and VIII were isolated from this plant for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alkaloids and lignans from stems of Piper betel was written by Huang, Xiangzhong;Yin, Yan;Huang, Wenquan;Sun, Kuizong;Cheng, Chunmei;Bai, Lian;Dai, Yun. And the article was included in Zhongguo Zhongyao Zazhi in 2010.HPLC of Formula: 18836-52-7 The following contents are mentioned in the article:

Alkaloids and lignans from the stems of Piper betel were studied. Compounds were isolated and purified by repeated silica gel, reverse phase silica gel, Sephadex LH-20 column chromatog., and preparative thin layer chromatog. The structures were elucidated on the basis of spectral anal. From the Et acetate soluble fractions of the 70% acetone extract, 10 compounds were isolated and identified as piperine; pellitorine; N-isobutyl-2E,4E-dodecadienamide; dehydropipernonaline; piperdardine; piperolein-B; guineensine; (2E,4E)-N-isobutyl-7-(3′,4′-methylene dioxyphenyl)-2,4-heptadienamide; syringaresinol-O-β-D-glucopyranoside; and pinoresinol (10). All compounds were isolated from the plant for the first time, and syringaresinol-O-β-D-glucopyranoside and pinoresinol were isolated from the genus for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7HPLC of Formula: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anticholinesterases and antioxidant alkamides from Piper nigrum fruits was written by Tu, Yanbei;Zhong, Yujiao;Du, Hongjian;Luo, Wei;Wen, Yaya;Li, Qin;Zhu, Chao;Li, Yanfang. And the article was included in Natural Product Research in 2016.HPLC of Formula: 18836-52-7 The following contents are mentioned in the article:

The anticholinesterase and antioxidant effects of five different extracts of Piper nigrum were evaluated. Twenty-one known alkamides were isolated from active Et acetate extract and investigated for their cholinesterase inhibitory and antioxidant effects. Among them, piperine, piperettine and piperettyline exhibited dual inhibition against AChE and BChE, and feruperine was the most potent selective inhibitor of BChE. Mol. docking simulation was performed to get insight into the binding interactions of the ligands and enzymes. In addition, N-trans-feruloyltyramine contributed to the strongest DPPH radical-scavenging activity. The self-induced Aβ aggregation inhibition of, and was further evaluated. Results indicated that some alkamides could be multifunctional lead candidates for Alzheimer’s disease therapy. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7HPLC of Formula: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti was written by Park, Il-Kwon. And the article was included in Natural Product Research in 2012.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined On the basis of 24-h LD₅₀ values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 μg/female) followed by guineensine (1.9 μgfemale/), retrofractamide A (2.4 μg/female) and pipercide (3.2 μg/female). LD₅₀ value of chlorpyrifos was 0.03 μg/female. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 μg/) than in retrofractamide A (1.5 μg/female), guineensine (1.7 μg/female), and pipercide (2.0 μg/female). LD₅₀ value of chlorpyrifos was 0.0014 μg/female. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum was written by Bodiwala, Hardik S.;Singh, Gaganmeet;Singh, Ranvir;Dey, Chinmoy Sankar;Sharma, Shyam Sundar;Bhutani, Kamlesh Kumar;Singh, Inder Pal. And the article was included in Journal of Natural Medicines in 2007.Electric Literature of C14H25NO The following contents are mentioned in the article:

The n-hexane, Et acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/mL. Two lignans, cubebin and hinokinin, were isolated from the hexane extract of P. cubeba; and one bis-epoxy lignan, (-)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 μM and were further tested in vivo in a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial activity of these two plants and their isolated constituents. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A new phenylpropanoid glucoside from Remusatia vivipara (Araceae) was written by Tang, Guihua;Wang, Yuehu;Long, Chunlin. And the article was included in Yunnan Zhiwu Yanjiu in 2010.Application of 18836-52-7 The following contents are mentioned in the article:

A new phenylpropanoid glucoside, caffeyl alc.-3-O-β-D-glucopyranoside, together with nine known compounds, was isolated from the dry corms of Remusatia vivipara Schott. The structure of the new compound was determined by the spectroscopic method and acidic hydrolysis. The known compounds included three phenylpropanoids (coniferin, caffeyl alc. and coniferyl alc.), three neolignans [4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolign-7′-ene, (7 R, 8 S)-Δ⁷-3,3′-dimethoxy-4,7,9,9′-tetrahydroxy-8-O-4′-neolignan-7-O-β-D-glucopyranoside and dehydrodiconiferyl alc.-4-β-D-glucoside], an amide [(2E,4E)-N-isobutyl-2,4-decadienamide], a steroid saponin (Me proto-taccaoside) and a triterpenoid saponin (saxifragifolin B). All compounds were isolated from the genus Remusatia for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical constituents and antibacterial activity from the stems and leaves of Piper wallichii was written by Nongmai, Chalini;Kanokmedhakul, Kwanjai;Promgool, Trinop;Paluka, Jakkapat;Suwanphakdee, Chalermpol;Kanokmedhakul, Somdej. And the article was included in Journal of Asian Natural Products Research in 2022.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

A phytochem. investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, an aryl alkanone, piwalkanone () and a dioxoaporphine alkaloid, piwallidione (), together with nine known compounds, a dioxoaporphine alkaloid, cepharadione A (); two aristolactams, piperolactam A () and stigmalactam (); a piperidine, piperine (); four isobutylamides, piperlonguminine (), pellitorine (), N-isobutyl-2E,4E-octadecadienamide (), and guineensine (); and a tyramine, N-trans-feruloyltyramine (). Their structures were elucidated on the basis of spectroscopic evidence (IR, 1H NMR, 13C NMR and 2 D NMR) and MS. Compounds and showed inhibitory activities against pathogenic bacteria, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Piperamides and their derivatives as potential anti-trypanosomal agents was written by Cotinguiba, Fernando;Regasini, Luis Octavio;Bolzani, Vanderlan da Silva;Debonsi, Hosana Maria;Duo Passerini, Gabriela;Cicarelli, Regina Maria Barretto;Kato, Massuo Jorge;Furlan, Maysa. And the article was included in Medicinal Chemistry Research in 2009.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

We describe herein an evaluation of the trypanocidal effect of eight piperamides (1-8) isolated from Pipertuberculatum bearing dihydropyridone, piperidine, and iso-Bu moieties against epimastigote forms of Trypanosoma cruzi, the causative agent of Chagas’ disease. Based on such results, three hydrogenated and two hydrolyzed derivatives (10-14) were prepared and evaluated as well. The dihydropyridone amides (1-3) displayed higher anti-trypanosomal activity. The (Z)-piplartine (1) showed higher activity with a 50% inhibition concentration (IC₅₀) value of 10.5 μM, almost four times more potent than the pos. control, benznidazole (IC₅₀ = 42.7 μM), and should be further evaluated as a suitable hit for the design of new antiprotozoal agents. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A review on traditional usage, phytochemistry, anticancer molecules of Piper nigrum L. (Indian pepper) was written by Chowdhury, U.;Baruah, P. K.. And the article was included in Annals of Plant Sciences in 2021.Product Details of 18836-52-7 The following contents are mentioned in the article:

A review. Piper nigrum L. is a historic spice yielding plant and its fruit forms an integral part of human diet. It comprises of versatile mols. with prime pharmacol. actions and therapeutic use including those that are very promising for the combat of dreaded disease such as cancer. Piperine, pellitorine and piperidine are important antitumor mols. present in the plant that are ideal for inclusion in the battery of approaches in cancer therapy. This plant may still be explored considering the medicinally important biomols. inherent in it. This study was aimed at making a systematic with regard to data on traditional uses and pharmacol. attributes of the biomols. that are present in the plant, particularly those having antitumor potentiality. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics