Category: 18836-52-7

Effects of Achillea tenuifolia Lam. hydro-alcoholic extract on anxiety-like behavior and reproductive parameters in rat model of chronic restraint stress was written by Bagheri, Y.;Fathi, E.;Maghoul, A.;Moshtagh, S.;Mokhtari, K.;Abdollahpour, A.;Montazersaheb, S.;Bagheri, A.. And the article was included in Human & Experimental Toxicology in 2021.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Achillea tenuifolia Lam (AT) has several biol. activities and medicinal properties. In this study, we elucidated the impact of the AT on anxiety-related behaviors, reproductive parameters, antioxidant capacity in male rats subjected to chronic restraint stress (CRS). 35 Wistar rats were divided into five groups: control, CRS-control (received normal saline) and three CRS-treated groups received AT extract (100, 150, and 200 mg/kg body weight) for 21 consequences days. To induce CRS rats, the rats were immobilized for 21 days and received the extract orally. On the last day of treatment, anxiety-related behaviors were assessed through the sucrose preference test (SPT) as well as elevated plus maze (EPM) tests. Corticosterone, LH (LH), and FSH (FSH), testosterone levels were evaluated to determine reproductive capacity. Sperm parameters including the total count, motility, and viability were also analyzed. Weight of body, testis and seminal vesicles was measured as well. The findings revealed that 100, 150, and 200 mg/kg of AT extract had anxiolytic effects in CRS rats, as confirmed by the EPM test and SPT. In addition, AT extract could improve fertile capacity and sperm quality to varying degrees. The level of corticosterone had decreased, whereas the level of LH, FSH and testosterone had increased in CRS-treated rats. Moreover, the reduced level of MDA coincided with an increased rate of antioxidant capacity. Our findings suggest that AT extract could alleviate stress-induced dysfunctions. Overall, these observations would infer that AT extract could improve fertility capacity and behavioral impairment in the stress conditions. Assumption pathway describing the probability underlying mechanism of CRS-induced anxiety and reproductive toxicity and protective effect of AT. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite was written by Goodman, Christopher Dean;Austarheim, Ingvild;Mollard, Vanessa;Mikolo, Bertin;Malterud, Karl Egil;McFadden, Geoffrey I.;Wangensteen, Helle. And the article was included in Malaria Journal in 2016.Reference of 18836-52-7 The following contents are mentioned in the article:

Background:Zanthoxylum heitzii (Rutaceae) (olon) is used in traditional medicine in Central and West Africa to treat malaria. To identify novel compounds with anti-parasitic activity and validate medicinal usage, extracts and compounds isolated from this tree were tested against the erythrocytic stages of the human malaria parasite Plasmodium falciparum and for inhibition of transmission in rodent malaria parasite Plasmodium berghei. Results: Hexane bark extract showed activity against P. falciparum (IC₅₀ 0.050μg/mL), while leaf and seed extracts were inactive. Fractionation of the hexane bark extract led to the identification of three active constituents; dihydronitidine, pellitories and heitziquinone. Dihydronitidine was the most active compound with an IC₅₀ value of 0.0089μg/ ml (25 nM). This compound was slow acting, requiring 50% longer exposure time than standard anti-malarials to reach full efficacy. Heitziquinone and pellitorine were less potent, with IC₅₀ values of 3.55μg/mL and 1.96μg/mL, but were fast-acting. Plasmodium berghei ookinete conversion was also inhibited by the hexane extract (IC₅₀ 1.75μg/mL), dihydronitidine (0.59μg/mL) and heitziquinone (6.2μg/mL). Water extracts of Z. heitzii bark contain only low levels of dihydronitidine and show modest anti-parasitic activity. Conclusions: Three compounds with anti-parasitic activity were identified in Z. heitzii bark extract The alkaloid dihydronitidine is the most effective of these, accounting for the bulk of activity in both erythrocytic and transmission-blocking assays. These compounds may present good leads for development of novel anti-malarials and add to the understanding of the chem. basis of the anti-parasitic activity in these classes of natural product. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Micropropagation of Anacyclus pyrethrum and chemical profiling of the regenerated plants for pellitorine, the active principle was written by Singh, Deepak K.;Nirwan, Shradha;Babbar, Shashi B.. And the article was included in Plant Cell, Tissue and Organ Culture in 2015.Reference of 18836-52-7 The following contents are mentioned in the article:

The paper reports the development of a protocol for large-scale micropropagation of Anacyclus pyrethrum, an invaluable medicinal plant, and the presence of pellitorine, the active principle, in leaves and roots of regenerated plants. Three explants-cotyledonary nodes, hypocotyls and cotyledons-were compared for their shoot development/differentiation ability on Murashige and Skoog’s (MS, Physiol Plant 15:473-497, 1962) medium supplemented with 1-10 μM of 6-benzylaminopurine (BAP) or kinetin (Kn). The best response (8.88 ± 0.28 shoots per explant) was elicited from the cotyledonary nodal explants on MS + 2.5 μM Kn. The in vitro regenerated shoots continued to multiply on being sub-cultured on the same medium. Elongated shoots were cultured on MS medium augmented with different concentrations (0.2-15 μM) of 1-naphthalene acetic acid (NAA), indole-3-acetic acid (IAA) or indole-3-butyric acid (IBA) for induction of roots. The media augmented with 5 or 10 μM IAA or 5 μM NAA were the most effective for the initiation and proliferation of roots. The plantlets were successfully transferred to the following three potting mixtures: garden soil, vermiculite and garden soil (1:1), vermiculite, garden soil and perlite (1:1:1). Among these, the maximum number (75 %) of the transferred plants survived in the garden soil. The high performance liquid chromatog. analyses of roots and leaves of the regenerated plants as well as those from the native habitat revealed the presence of pellitorine in all, with the content being higher in the roots than the corresponding leaves. The developed protocol would be of use for production of A. pyrethrum plants throughout the year, and thus could become a perennial source of the herb and its active principle. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis and evaluation of a series of alkylsiloxane-bonded stationary phases for expanded supercritical fluid chromatography separations was written by Fu, Qing;Jiang, Dasen;Xin, Huaxia;Dai, Zhuoshun;Cai, Jianfeng;Ke, Yanxiong;Jin, Yu;Liang, Xinmiao. And the article was included in Journal of Chromatography A in 2019.Application of 18836-52-7 The following contents are mentioned in the article:

Supercritical fluid chromatog. (SFC) today represents an alternative technique in anal. chem. due to its obvious benefits in kinetic performance and its complementarity to liquid chromatog. In this paper, a series of alkylsiloxane-bonded stationary phases were synthesized and evaluated to expand their SFC applications. Five kinds of non-endcapped C8 stationary phases (C8-1 to C8-5) with increasing bonding d. were synthesized, and the carbon content was 3.91%, 6.07%, 7.97%, 8.65% and 9.10% resp. Retention mechanism of the C8 phases in SFC in SFC was investigated by the use of a linear solvation energy relationship (LSER) model. Results underlined a close relationship between the bonding d. of alkyl chain and the dispersion and polar interactions of the stationary phase. Complementary evaluation was studied based on the calculation of vector angle (θ), and the widest θ of 123° was found between silica and C8 with the highest bonding d. Selective diversity also existed between the two C8 phases with the highest and lowest bonding densities. In addition, the effect of modifier on the SFC mechanism was investigated. Modifiers (methanol, ethanol, isopropanol and acetonitrile) had insignificant influence on the dispersion interaction but they mainly affected the hydrogen bonding interaction by changing the LSER parameters a and b. Finally, C8 and silica columns were applied for separation of eight amide alkaloids of Piper kadsura. Silica provided better retention but limited selectivity while C8 can distinguish alkaloids different in alkyl chain, double bond and cis-trans structure. This research further contributed to demonstrate the potential of alkylsiloxane-bonded stationary phase in improving selectivity of SFC. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Simultaneous determination of six marker compounds in Piper nigrum L. and species comparison study using high-performance thin-layer chromatography-mass spectrometry was written by Ramesh, Bokka;Sarma, Vanka Uma Maheswara;Kumar, Katragunta;Babu, Katragadda Suresh;Devi, Potturi Sita. And the article was included in Journal of Planar Chromatography–Modern TLC in 2015.Electric Literature of C14H25NO The following contents are mentioned in the article:

The isolation and characterization of bioactive compounds from medicinal plants is usually a significant challenge in phytochem. anal. because of the natural chem. complexity of plant extracts However, there exists a need for anal. tools which can quant. sep. and characterize the components from these biosources with greater chromatog. selectivity and lesser anal. run times that facilitate the evaluation with enhanced separation profiles. Hyphenation of thin-layer chromatog. (TLC/HPTLC) with mass spectrometry (MS) is an alternative for screening herbal extracts because of its rapid anal. and ability to aid structural characterization with powerful anal. capacity. The aim of the present study was to develop a sophisticated anal. method which utilizes HPTLC-MS coupling for the chromatog. profiling and evaluation of the therapeutically important genus Piper (Piperaceae). In this study, six marker compounds, namely, trichostachine, piperine, 4,5-dihydropiperlonguminine, guineensine, pellitorine, and sesamin were analyzed and quantified in extracts of Piper nigrum L. and compared with those of Piper longum L. and Piper chaba Hunter. All the samples tested showed similar phytochem. profiles, but the contents of the active ingredients varied. Addnl., HPTLC-MS further allowed confirming the identification of the constituents in the analyzed samples with greater chromatog. selectivity where HPTLC facilitated a selective chromatog. resolution, while MS offered an efficient characterization of the target compounds in one anal. run. The study finds a potential utility in adopting HPTLC-MS as a rapid and high throughput method for the efficient quantification and identification of marker compounds from medicinal plants. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In silico analysis of medicinal plants against Mycobacterium tuberculosis (MTB) was written by Sathish Kumar, R.;Sankaravel, V.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2018.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Tuberculosis (TB) is a deadly infectious disease caused by the Mycobacterium tuberculosis (MTB). Tuberculosis mostly affects the lungs at later stages it also affects other organs. The protein epoxide hydrolase plays a major role in drug metabolism as well as signal processing mol. and therefore has been targeted in the present study. The medicinal plants being a solution for several human ailments, also act as a reservoir for secondary metabolites, has taken its credit as a cure from our ancient times. The compounds reported earlier in the plants Solanum torvum, Piper longum, Morinda citrifolia, Cocos nucifera, Dissotis rotundifolia, Curcuma longa, Aloe vera, Ocimum basillicum, Centella asiatica and Dipterocarpus sublamelatous were analyzed for its possible significant interaction with the target protein using mol. docking studies.The compounds from the plants Solanum torvum, Piper longum, Morinda citrifolia, Cocos nucifera, Dissotis rotundifolia, Curcuma longa, Aloe vera, Ocimum basillicum, Centella asiatica and Dipterocarpus sublamelatous were analyzed using the mol. docking studies ADME-properties, drug-likeness using the Schrodinger software.The docking results were observed which indicated that the compound catechin scored significant G.score of -8.74 Kcal/mol among the other compounds tested. The interactions were observed with amino acid residue tyrosine at two different positions 164 and 272, each of bond length of 2.1Å. The compound Catechin had significant interaction with the target protein, could be further analyzed for stability using mol. dynamics study and in vitro. The future perspective of the study is to determine the stability of the protein-compound complex through dynamics studies. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification of interactions between multiple components in Socheongryong-tang using a plant profiling approach was written by Oh, Hyun-A.;Lee, Hyunbeom;Kang, Keon Wook;Im, Ji Hye;Kim, Donghak;Yang, Hyun Ok;Jung, Byung Hwa. And the article was included in Biomedical Chromatography in 2019.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Traditional herbal medicine consists of multiple components. There are interactions among the components, which affect both potency and toxicity. The preparation of herbal medicines can be a cause of interactions between multicomponents in herbs. To demonstrate the differences in multiherb interactions based on the preparation methods, the changes in the active components in the different preparations of Socheongryong-tang (SCRT) were evaluated using metabolomics profiling. We performed multicomponent profiling of the decoction of SCRT (SCRTD) and individual herb mixture (SCRTM) using ultra-high-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Active compounds from SCRTD and SCRTM were identified using multivariate anal., and the activities between the two groups were compared. We also evaluated the anti-inflammatory effect of SCRT through investigating the protein expression of iNOS and COX-2 in lipopolysaccharide-induced macrophage RAW 264.7 cells in both groups. From the multivariate anal., 53 active compounds that have different intensities between SCRTD and SCRTM were identified. The intensities of those components, such as ephedrines, glycyrrhizic acid, 6-gingerol and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide, which is newly identified in Asiasarum heterotropoides, were mostly higher in SCRTD than in SCRTM, which was related to the anti-inflammatory effect. From the iNOS inhibition test, it was found that SCRTD had a stronger anti-inflammatory effect than SCRTM. It was demonstrated that multicomponent interactions can be changed by the preparation method, and finally the anti-inflammatory effect in SCRT can be affected. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Simultaneous quantification of three amides by gas chromatography time of flight mass spectrometry in extracts of Piper sarmentosum was written by Hussain, Khalid;Ismail, Zhari;Sadikun, Amirin;Ibrahim, Pazilah. And the article was included in Analytical Chemistry: An Indian Journal in 2009.Product Details of 18836-52-7 The following contents are mentioned in the article:

Piper sarmentosum is well known due to its culinary and medicinal properties and has a great potential of commercialization. Herbal standardization is a tedious task mainly due to un-availability or inadequacy of methods and standards, and its lacking is the single biggest hindrance in the acceptance of herbal products in main stream of pharmaceuticals. Therefore, present study aimed to develop an anal. method using gas chromatog. time of flight mass spectrometry for the simultaneous quantification of three amides, which can be used as pharmacol. active anal. markers to standardize the product made from this plant and others containing these compounds Three amides, pellitorine, sarmentine, and sarmentosine isolated and identified previously from fruit of the plant were used as markers to develop and validate the method. Lowest limit of detection (LOD) of the three amides were found to be 0.10, 0.10 and 0.12 ng/mL, resp., at a signal to noise ratio 3:1, whereas the lowest limit of quantification (LOQ) was taken 1.00, 1.00, and 12.00 ng/mL, resp., at a signal to noise ration 10:1. The method was found to be linear (R² = 0.9985 to 0.9995) with RSD < 5%. Intraday and inter day accuracy was found to be 97.40-100.00% with precision (RSD <5%). The percentage recoveries were 97-100% with RSD <5%. The method was found sensitive and reproducible, and applied successfully to quantify the amides in ethanol and supercritical CO₂ extracts of fruit of Piper sarmentosum. The method is found to be simple, fast and easy to perform, and may be helpful for natural product industry as well as natural product scientists to produce standardized extracts and products from the plant. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

From Natural to Synthetic Quorum Sensing Active Compounds: Insights to Develop Specific Quorum Sensing Modulators for Microbe-Plant Interaction was written by Gutierrez-Villagomez, Juan Manuel;Ramirez-Chavez, Enrique;Molina-Torres, Jorge;Vazquez-Martinez, Juan. And the article was included in ACS Symposium Series in 2020.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

It is clear the importance of plant-microbe interactions to accomplish food safety and sustainable agriculture. Many plant-microbe interactions depend on bacterial quorum sensing (QS) systems, so the manipulation of these communication systems could be a powerful instrument to modulate plant development. The search of compounds with the capacity to modulate the microbial communication systems using docking mol. anal. methods along with chromatog. and miniaturized microbiol. techniques offers a robust tool-kit for designing and testing quorum quenching (QQ) active compounds Further, the synthesis of QQ compounds can be achieved by applying enzymic processes with the advantages of lowering costs and generating fewer byproducts. To exemplify these processes, herein, a group of natural compounds known as alkamides and piperamides were tested using mol. docking simulations to detect QQ active compounds against the CviR and LasR QS receptors of Gram-neg. bacteria. The docking results show that some alkamides and piperamides bind specifically to each of the studied QS receptors. The structural anal. of the resp. crystalized-receptor native ligand and the best-docked alkamide/piperamide was used to design acyl amide-like compounds These new acyl amide-like compounds bind more efficiently to the studied QS receptors than the native ligands, according to the docking results. The designed compounds could also potentially modulate plant-microbe interactions related to cellular processes dependent on bacterial QS. The data we describe contributes to the understanding of plant-microbe interactions and investigates methods to modulate plant-microbe interactions that can impact sustainable food production This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bioactive markers based pharmacokinetic evaluation of extracts of a traditional medicinal plant, Piper sarmentosum was written by Hussain, Khalid;Ismail, Zhari;Sadikun, Amirin;Ibrahim, Pazillah. And the article was included in Inventi Impact: Ethnopharmacology in 2012.Reference of 18836-52-7 The following contents are mentioned in the article:

In vitro assays are economical and easy to perform but to establish relevance of their results to real clin. outcome in animals or human, pharmacokinetics is prerequisite. Despite various in vitro pharmacol. activities of extracts of Piper sarmentosum, there is no report of pharmacokinetics. Therefore, the present study aimed to evaluate ethanol extract of fruit of the plant in dose of 500 mg kg^-1 orally for pharmacokinetics. Sprague-Dawley rats were randomly divided into groups 1, 2, and 3 (each n = 6) to study absorption, distribution and excretion, resp. High performance liquid chromatog. (HPLC) with UV detection was applied to quantify pellitorine, sarmentine and sarmentosine in plasma, tissues, feces and urine to calculate pharmacokinetic parameters. Pellitorine exhibited maximum plasma concentration (C_max) 34.77 ng mL^-1 ± 1.040, time to achieve C_max (T_max) 8 h, mean resident time (MRT) 26.00 ± 0.149h and half life (t_1/2) 18.64 ± 1.65 h. Sarmentine showed C_max 191.50 ± 12.69 ng mL^-1, T_max 6h, MRT 11.12 ± 0.44h and t_1/2 10.30 ± 1.98h. Sarmentosine exhibited zero oral bioavailability because it was neither detected in plasma nor in tissues, and in urine. Pellitorine was found to be distributed in intestinal wall, liver, lungs, kidney, and heart, whereas sarmentine was found only in intestinal wall and heart. The cumulative excretion of pellitorine, sarmentine and sarmentosine in feces in 72 h was 0.0773, 0.976, and 0.438 μg, resp. This study shows that pellitorine and sarmentine have good oral bioavailability while sarmentosine is not absorbed from the gastrointestinal tract. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics