Category: 188345-71-3

Related Products of 188345-71-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 188345-71-3 name is 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a method analogous to J. Malpass and C. Cox, Tetrahedron Lett., 1999, 40, 1419-1422, tert-butyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate is treated with diborane to afford a mixture of alcohols which is separated by chromatography. The desired alcohol tert-butyl 6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate is then oxidized using the Swern procedure to afford the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, and friends who are interested can also refer to it.

Reference:
Patent; Lampe, John W.; Watson, Paul S.; Slade, David J.; US2011/144150; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 188345-71-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 188345-71-3 name is 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a method analogous to J. Malpass and C. Cox, Tetrahedron Lett., 1999, 40, 1419-1422, tert-butyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate is treated with diborane to afford a mixture of alcohols which is separated by chromatography. The desired alcohol tert-butyl 6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate is then oxidized using the Swern procedure to afford the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, and friends who are interested can also refer to it.

Reference:
Patent; Lampe, John W.; Watson, Paul S.; Slade, David J.; US2011/144150; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 188345-71-3, name is 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 188345-71-3, Safety of 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene

2.22 Preparation of Compound 4 A stream of O3 was bubbled through a solution of compound 3 (8.0 g, 41 mmol) in CH3CO2H (21 mL) and DCM (350 mL) at -50-60 C. until the solution turned blue. Excess O3 was removed with O2, and Me2S (7.7 mL) was added dropwise to the solution. The mixture was allowed to warm gradually to rt and stirred for 16 h under N2. The solution was concentrated and the residue was used for the next step directly.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hartman, George D.; US2015/132258; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 188345-71-3, name is 2-Boc-2-Azabicyclo[2.2.1]hept-5-ene, A new synthetic method of this compound is introduced below., SDS of cas: 188345-71-3

2-(Tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene was dissolved in 200 mL of dichloromethane-methanol (2:1), and the solution was cooled to -78 C. Ozone was passed through the solution until it turned blue and then for a further 10 min. Argon was bubbled through the solution to remove excess ozone (the solution turned colorless). This process (ozone, followed by argon) was repeated one more time to ensure complete formation of the ozonide. Sodium borohydride (3.7 g, 97 mmol) was carefully added to the reaction mixture at -78 C., and the resulting mixture stirred for 16 h, as the temperature of the reaction was gradually increased to ambient. Saturated ammonium chloride solution (100 mL) was added, and the mixture was stirred for an additional 1 h. The mixture was extracted with dichloromethane (2¡Á150 mL), and the combined organic extracts were dried over anhydrous magnesium sulfate. The solvent was removed by rotary evaporation to give 1-(tert-butoxycarbonyl)-2,4-bis(hydroxymethyl)pyrrolidine, as a light yellow oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Targacept, Inc.; US2011/263629; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics