Bowler, Frank R. published the artcileDNA Analysis by Dynamic Chemistry, HPLC of Formula: 186046-83-3, the publication is Angewandte Chemie, International Edition (2010), 49(10), 1809-1812, S1809/1-S1809/29, database is CAplus and MEDLINE.
Herein we report the application of dynamic chem. to DNA anal., offering the prospect of nonenzymic genotyping of genomic DNA amplified by polymerase chain reaction (PCR). This was achieved by the synthesis of a PNA strand that contained a blank position opposite the nucleobase under anal. in a complementary DNA template. A reversible reaction, between this PNA/DNA duplex (specifically the secondary amine of the “PNA blank”) and four aldehyde-modified nucleobases, means that the templating power of Watson-Crick base pairing and base stacking would be expected to drive the selection of the fully complementary iminium nucleobase. Subsequent reduction and MALDI-TOF mass spectrometry would allow rapid determination of base incorporation.
Angewandte Chemie, International Edition published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, HPLC of Formula: 186046-83-3.
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https://en.wikipedia.org/wiki/Amide,
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