Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 185619-66-3, name is tert-Butyl (3-ethynylphenyl)carbamate, A new synthetic method of this compound is introduced below., Formula: C13H15NO2
Step b) [3-(4-Difluoromethoxy-phenylethynyl)-phenyl]-carbamic acid tert-butyl ester A mixture of (3-ethynyl-phenyl)-carbamic acid tert-butyl ester (14.7 g, 67.7 mmol), 1-difluoromethoxy-4-iodo-benzene (18.2 g, 67.7 mmol), NEt3 (47 mL, 338 mmol), acetonitrile (225 mL), CuI (1.29 g, 6.77 mmol), and Pd(PPh3)2Cl2 (2.85 g, 4.05 mmol) was heated to 60 C. for 1 h. The reaction was diluted with EtOAc/Hex (1:10) and then passed through a pad of silica gel and concentrated and purified with chromatography using hexanes/ethyl acetate (10:1) as the eluding solvents gave the title compound (24.3 g, 100%), characterized by NMR and mass spectral analyses.
The synthetic route of 185619-66-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WYETH; US2009/48320; (2009); A1;,
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