Adding a certain compound to certain chemical reactions, such as: 18437-67-7, name is tert-Butyl m-tolylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18437-67-7, category: amides-buliding-blocks
General procedure: To a mixture of tert-butyloxycarbamates (8.0 mmol), K3PO4 (16 mmol), CuSO4*5H2O (0.8 mmol), and 1,10-phenanthroline (1.6 mmol) in a reaction vial was added a solution of bromoalkyne (8.8 mmol) in toluene (15 mL).The reaction mixture was capped and heatedin an oil bath at 85 C for 18 h while being monitored with TLC analysis. Upon completion, the reaction mixture was cooled to room temperature and diluted with EtOAc and filtered through Celite, and the filtrate was concentrated in vacuum. The crude products were purified by silica gel flash chromatography on a silica gel column with petroleum ether (PE) and ethylacetate (EA) as eluent to afford directing products.
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Reference:
Article; Huang, Hai; Tang, Luning; Xi, Yang; He, Guangke; Zhu, Hongjun; Tetrahedron Letters; vol. 57; 17; (2016); p. 1873 – 1876;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics