Category: 17641-08-6

Application of 17641-08-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To the appropriate Schiff bases of isatin (10 mmol) in8-10 cm3 of anhydrous DMF, K2CO3 (15 mmol) was addedand stirred at room temperature for 1 h. After completion of1 h, the solution turned red brown in color. Appropriatechloroanilides (10 mmol) and KI (2 mmol) were then addedto this solution drop wise and heated at 60 C for 5.5-9 h.After conforming the end of reaction by TLC (ethyl acetate:n-hexane 30:70), the mixture was poured into ice cold water.Precipitated crude product was filtered and washed thoroughlywith cold water (3 9 200 cm3). Compounds wererecrystallized from ethanol/water mixture (1:1). Reactiontimes, melting points, and yields are depicted in Table 1.

The synthetic route of 2-Chloro-N-(3-methoxyphenyl)acetamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Debnath, Biplab; Ganguly, Swastika; Monatshefte fur Chemie; vol. 147; 3; (2016); p. 565 – 574;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 17641-08-6,Some common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The oxime 6 or 8 (0.7 mmol) and K2CO3(0.116 g, 0.84 mmol) were taken in dry DMF (5 mL), cooled to 0 Cand stirred for 30 min, then N-substituted acetamide (0.77 mmol)was added. The total reaction mixture was stirred at room temperature for 12-20 h. The reaction was monitored by TLC and after completion of the reaction, treated with ice cold water. Aqueous solution was extracted thrice with ethylacetate, combined extracts were washed with water till washings are neutral to pH, dried over anhydrous sodium sulfate and concentrated. The residue was purifiedby passing through a column packed with silica gel using petroleum ether/EtOAc (8:2) as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N-(3-methoxyphenyl)acetamide, its application will become more common.

Reference:
Article; Gannarapu, Malla Reddy; Vasamsetti, Sathish Babu; Punna, Nagender; Royya, Naresh Kumar; Pamulaparthy, Shanthan Rao; Nanubolu, Jagadeesh Babu; Kotamraju, Srigiridhar; Banda, Narsaiah; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 143 – 150;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H10ClNO2

2) 2-chloro-N-(3-methoxyphenyl)acetamide (3.1g, 16 mmol) and anhydrous AlCl3 powder (4.4g,32 mmol) is heated and stirred at 120C for 10 minutes and exhibit a melting state. The temperature is elevated gradually to 240C in 40 minutes and then stirred 5 minutes. The reaction is allowed to cool to obtain a brown powder. The solid powder is poured into a mixture of 100g of crushed ice and 50ml of concentrated hydrochloric acid. The mixture is stirred for 10 minutes and then reflux for 10 minutes, and allowed to cool to precipitate a light yellow powder, which is filtered out and recrystallized in water to obtain 1.5g of 6-hydroxy-indoline-2-one, with a yield of 62%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry; EP2322520; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 17641-08-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To the appropriate Schiff bases of isatin (10 mmol) in8-10 cm3 of anhydrous DMF, K2CO3 (15 mmol) was addedand stirred at room temperature for 1 h. After completion of1 h, the solution turned red brown in color. Appropriatechloroanilides (10 mmol) and KI (2 mmol) were then addedto this solution drop wise and heated at 60 C for 5.5-9 h.After conforming the end of reaction by TLC (ethyl acetate:n-hexane 30:70), the mixture was poured into ice cold water.Precipitated crude product was filtered and washed thoroughlywith cold water (3 9 200 cm3). Compounds wererecrystallized from ethanol/water mixture (1:1). Reactiontimes, melting points, and yields are depicted in Table 1.

The synthetic route of 2-Chloro-N-(3-methoxyphenyl)acetamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Debnath, Biplab; Ganguly, Swastika; Monatshefte fur Chemie; vol. 147; 3; (2016); p. 565 – 574;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Chloro-N-(3-methoxyphenyl)acetamide

General procedure: To a stirred solution of substituted aniline (1 mmol) and chloroacetyl chloride (1 mmol) which was stirred in 5 mL DMF for 20 min, were added benzyl amine derivatives (1.3 mmol) and CS2 (5 mmol). The reaction mixture was allowed to stir for required additional time (Table 2). Then, 5 mL of water was added and the solution was extracted with ethyl acetate and dried over sodium sulfate and purified by passing over a silica gel column chromatography using petroleum ether/ethyl acetate (8:2).

The synthetic route of 17641-08-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sadat-Ebrahimi, Seyed Esmail; Karim, Leila; Moghimi, Setareh; Yahya-Meymandi, Azadeh; Mahdavi, Mohammad; Vosooghi, Mohsen; Foroumadi, Alireza; Shafiee, Abbas; Journal of Sulfur Chemistry; vol. 38; 1; (2017); p. 43 – 51;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H10ClNO2

General procedure: A mixture of 2-chloro-N-(4-chlorobenzyl)acetamide 3a (0.22 g, 1.0 mmol), 4-hydroxy-N-phenethyl-benzenesulfonamide 7a (0.42 g, 1.5 mmol), K2CO3 (0.21 g, 1.5 mmol) and KI (33 mg, 0.2 mmol) in acetone (20 ml) was stirred at 60 C for 7.0 h. After the organic solvent was evaporated, the residual was diluted with water (20 ml), extracted with dichloromethane, washed with brine and then dried over Na2SO4. After filtration and condensation, the crude product was obtained and recrystallized in ethyl acetate/hexane (1:1, v: v) to afford 1a as white solid (0.19 g, yield 42%). SAPA 1v was prepared by the reaction of 2-chloro-N-(3-methoxyphenyl)acetamide 3q with 7a according to the procedure described for SAPA 1a. Yield 46%; mp 107.0-108.0 C. ESI-MS m/z 441.3 (M+H)+. HRMS (ESI) of C23H24N2O5S (M+H)+ calcd, 441.1479; found, 441.1479. 1H NMR (400 MHz, DMSO-d6) delta 10.13 (s, 1H), 7.71 (d, J = 8.7 Hz, 2H), 7.57 (s, 1H), 7.30 (s, 1H), 7.28-7.10 (m, 9H), 6.65 (d, J = 7.9 Hz, 1H), 4.79 (s, 2H), 3.70 (s, 3H), 2.91 (s, 2H), 2.65 (t, J = 7.5 Hz, 2H). 13C NMR (151 MHz, DMSO-d6) delta 166.4, 161.1, 160.0, 140.0, 139.2, 133.2, 130.1, 129.1, 128.8, 126.7, 115.5, 112.4, 109.7, 105.9, 67.5, 55.5, 44.6, 35.7. HPLC purity: tR = 8.100, 98.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17641-08-6, its application will become more common.

Reference:
Article; Li, Ya-Li; Qi, Xiang-Yu; Jiang, Hui; Deng, Xiao-Dong; Dong, Yan-Ping; Ding, Ting-Bo; Zhou, Lu; Men, Peng; Chu, Yong; Wang, Ren-Xiao; Jiang, Xian-Cheng; Ye, De-Yong; Bioorganic and Medicinal Chemistry; vol. 23; 18; (2015); p. 6173 – 6184;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, A new synthetic method of this compound is introduced below., Safety of 2-Chloro-N-(3-methoxyphenyl)acetamide

General procedure: Various substituted anilines were dissolved in glacial acetic acid at0 C, to this was added over 30 min choloroacetyl chloride (2 equivalents).The reaction mixture was brought to room temperature andstirred overnight. Saturated sodium bicarbonate solution was added tillcomplete neutralization. The resulting precipitate was filtered off andwashed with n-hexane and dried. The resultant product (1) was usedfurther without any purification. Either of 4-hydroxy benzaldehyde(2a), vanillin (2b) or isovanillin (2c) (1 equivalent) was dissolved inacetone and potassium carbonate (2 equivalents) was added. Thencorresponding substituted acetamide (1) was mixed to the stirring solution.Finally, potassium iodide (1.5 equivalent) was added. The reactionmixture was refluxed for 8-10 h. After completion of reaction,the resultant mixture was concentrated and treated with water andextracted with ethyl acetate (3¡Á20 mL). The organic layers werecombined and treated with brine and dried over sodium sulfate andconcentrated. The crude mixture was purified over silica gel (60-120)using petroleum ether: ethyl acetate (9:1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Sonawane, Vinay R.; Siddique, Mohd Usman Mohd; Gatchie, Linda; Williams, Ibidapo S.; Bharate, Sandip B.; Jayaprakash, Venkatesan; Sinha, Barij N.; Chaudhuri, Bhabatosh; European Journal of Pharmaceutical Sciences; vol. 131; (2019); p. 177 – 194;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 17641-08-6, A common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13H-quinazolino[3,4-a]quinazolin-13-one 8 (1 mmol), 2-chloro-N-substituted acetamide 9 (1 mmol), and potassium iodide (1 mmol) in acetone (8 mL) was heated at room temperature for 5-48 h. After completion of the reaction, water (8 mL) was added to the reaction mixture, and the precipitates were filtered off and recrystallized from EtOH/H2O (90/10) to give the corresponding product 10.

The synthetic route of 17641-08-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mohammadhosseini, Negar; Saeedi, Mina; Moradi, Shahram; Mahdavi, Mohammad; Firuzi, Omidreza; Foroumadi, Alireza; Shafiee, Abbas; Turkish Journal of Chemistry; vol. 41; 1; (2017); p. 125 – 134;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 17641-08-6,Some common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 4-(5-mercapto-1,3,4-oxadiazol-2-yl)benzenesulfonamide (9) (1mmol), various substituted 2-chloro-N-phenylacetamide 11a-j (1mmol) and K2CO3 (1.5mmol) was refluxed in acetone (15ml) for 3-4h. The reaction was monitored with TLC and after completion of the reaction, excess of solvent was evaporated and diluted with water (about 100ml). The precipitated was separated out, filtered washed with water and recrystallized with an appropriate solvent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N-(3-methoxyphenyl)acetamide, its application will become more common.

Reference:
Article; Angeli, Andrea; Kumar, Rajiv; Sharma, Pawan K.; Sharma, Vikas; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 193; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Chloro-N-(3-methoxyphenyl)acetamide

General procedure: A mixture of the potassium salt 22 (1.5g, 0.01mol) and the appropriate chloroacetanilides (0.01mol) namely, 2-chloro-N-(3-methoxyphenyl)acetamide and 2-chloro-N- (4-fluorophenyl)acetamide in dry DMF (20ml) was heated over a water bath for 3h. The reaction mixture was then cooled, poured into ice-cooled water (150ml) and stirred well for 30min. The solid such separated was filtered, washed with water, dried and crystallized from methanol/toluene mixture (1:1) to afford the corresponding compounds 25a – b, respectively. 2-(Bis[1,2,4]triazolo[4,3-a:3?,4?-c]quinoxalin-3-ylsulfanyl)-N-(3-methoxyphenyl) acetamide (25a). White crystal (yield 71 %); m. p. 256 – 259 C; IR (KBr, cm1); 3264 (NH), 3077 (CH aromatic), 2950 (CH aliphatic), 1689 (C=O amide); 1H NMR (DMSO-d6) delta ppm: 3.70 (s, 3H, -OCH3), 4.52 (s, 2H, CH2), 6.62 (d, 1H, J=8.1Hz, Ar-H, H-4 of phenyl), 6.69 (d, 1H, J=8.4Hz, Ar-H, H-6 of phenyl), 7.20 (dd, 1H, J=8.1, 8.4Hz, Ar-H, H-5 of phenyl), 7.23 (s, 1H, Ar-H, H-2 of phenyl), 7.72 (dd, 1H, J=7.8, 8.4Hz, Ar-H, H-7 of quinoxaline), 7.74 (dd, 1H, J=7.8, 8.1Hz, Ar-H, H-6 of quinoxaline), 8.45 (d, 1H, J=8.4Hz, Ar-H, H-8 of quinoxaline), 8.59 (d, 1H, J=8.1Hz, Ar-H, H-5 of quinoxaline), 10.02 (s, 1H, Ar-H, N-CH=N), 10.54 (s, 1H, -NH, D2O exchangeable); 13C NMR (DMSO-d6, 100 MHz) delta (ppm): 38.9, 55.4, 105.4, 109.4, 111.8, 118.0, 118.5, 123.1, 124.0, 128.3 (2), 130.0, 138.7, 139.4, 140.3, 142.3, 147.7, 159.9, 165.5; DEPT (DMSO-d6, 100 MHz) delta (ppm): 38.9 (1CH3), 55.4 (1CH2), 105.3, 109.4, 111.8, 118.0, 118.5, 128.3 (2), 130.0, 138.7 (9CH); Anal. Calcd. for C19H15N7O2S (405.43): C, 56.29; H, 3.73; N, 24.18. Found: C, 56.42; H, 3.71; N, 24.39 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17641-08-6, its application will become more common.

Reference:
Article; Ibrahim; Taghour; Metwaly; Belal; Mehany; Elhendawy; Radwan; Yassin; El-Deeb; Hafez; ElSohly; Eissa; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 117 – 134;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics