17193-28-1 Archives - Amides-buliding-blocks

S News Extended knowledge of 17193-28-1

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17193-28-1, HPLC of Formula: C6H12N2O

To a solution of 1-aminocyclopentane-l-carboxamide (1.00 g, 7.80 mmol) in DCM (16 niL) was added TEA (2.72 niL, 19.50 mmol). The mixture was cooled with an ice bath. Cyclopropanecarbonyl chloride (1.142 g, 10.92 mmol) in DCM (4 mL) was added dropwise to the stirred solution, and the reaction mixture was at RT for 18 hours. The reaction was diluted with 0 and DCM. The organic phase was collected. The aqueous phase was extracted (2X) with DCM. The combined organic phase was washed with brine, dried over sodium sulfate, and concentrated to give Intermediate 119a (0.889g, 4.53 mmol, 58.1 % yield) as a solid. RT =0.49 min, MS (ESI) m/z: 191 A (M+H)+. 1H NMR (400 MHz, CDCl3) delta 5.91 (br s, 2H), 5.76 – 5.57 (m, 1H), 2.49 – 2.25 (m, 1H), 2.07 (br d, J=16.7 Hz, 1H), 1.93 – 1.74 (m, 2H), 1.67 – 1.28 (m, 2H), 1.28 – 1.19 (m, 2H), 1.03 – 0.97 (m, 2H), 0.90 – 0.82 (m, 2H), 0.81 – 0.74 (m, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

S News Sources of common compounds: 17193-28-1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 17193-28-1, A common heterocyclic compound, 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, molecular formula is C6H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1 -Fluoropentanoic acid (22, 350 mg, 2.91 mmol) were dissolved in dry dimethylfor- mamide (= DMF) (5 ml_) and triethylamine (= Et3N) (486 mI_, 353 mg, 3.49 mmol) was added. Then 1 -aminocyclopentanecaroxamide (373 mg, 2.91 mmol) and (2- (1 FI-benzotriazol-1 -yl)-1 ,1 ,3,3-tetramethyluronium hexafluorophosphate) (= FIBTU) (1324 mg, 3.49 mmol) were added. The mixture was stirred for 24 h at room tem- perature (= r.t.). Then water was added and the mixture was extracted wit ethyl ac- etate (3x). The combined organic layer was washed with water, saturated NaFIC03 solution and brine (2x), dried over Na2S04, filtered and evaporated to dryness in vacuo. The residue was purified by flash column chromatography (dichloro- methane/methanol = 98/2; Rf = 0.2) to yield 23 (668 mg, 99%) as colorless solid.1H NMR (400 MHz, CDCIs): d = 4.76 (t, J = 5.7 Hz, 1 H), 4.61 (t, J = 5.7 Hz, 1 H), 2.43 – 2.34 (m, 2H), 2.30 – 2.22 (m, 2H), 2.07 – 1 .99 (m, 2H), 1 .94 – 1 .73 (m, 8H) ppm.13C NMR (101 MHz, CDCIs): d = 175.57, 170.07, 82.94, 69.19, 34.94, 34.64,29.77, 29.62, 23.00, 21 .95 ppm.MS: 231 .05 [M+H]+

Reference:
Patent; JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG; CHEN, Xinyu; DECKER, Michael; HIGUCHI, Takahiro; HOFFMANN, Matthias; (0 pag.)WO2019/134765; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

10-Sep-2021 News Sources of common compounds: 17193-28-1

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H12N2O

6.19. Preparation of l-(4-(4-(2-nnet yl-5-((2S.3R.4R.5S.6R)-3.4.5-tririvdroxy-6- (met yltriio)tetra vdro-2H-pyran-2- yl)benzyl)prienoxy)butanannido)cvclopentanecarboxamide (41) 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2- yl)benzyl)phenoxy)butanoic acid (39, 46 mg, 0.10 mmol), 1-aminocyclopentanecarboxamide (26 mg, 0.20 mmol), HATU (57 mg, 0.15 mmol), and DIPEA (52 muIota_, 0.30 mmol) were combined in DMF (0.5 ml_) and stirred overnight at room temperature. The reaction was diluted with EtOAc, washed with saturated aqueous NaHC03 and brine (with back extraction), dried over MgS04, filtered, and concentrated under vacuum. The material was purified by prep HPLC (C18 30 x 100 mm column, 20-60% CH3CN /10 mM aqueous ammonium formate, 45 mL/min) and lyophilized to give 35 mg (61% yield) of amide 41 as a white solid. W NMR (400 MHz, MeOH-d4) delta ppm 7.10 – 7.19 (m, 3 H), 7.04 (d, J=8.6 Hz, 2 H), 6.81 (m, J=8.6 Hz, 2 H), 4.39 (d, J=9.3 Hz, 1 H), 4.12 (d, J=9.1 Hz, 1 H), 3.96 (t, J=6.2 Hz, 2 H), 3.92 (s, 2 H), 3.34 – 3.50 (m, 3 H), 2.41 (t, J=7.5 Hz, 2 H), 2.12 – 2.22 (m, 8 H), 2.04 (quin, J=6.9 Hz, 2 H), 1.93 (dt, J=12.8, 5.1 Hz, 2 H), 1.64 – 1.75 (m, 4 H); MS (ES+) [M+H]+ = 573.

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; CARSON, Kenneth Gordon; GOODWIN, Nicole Cathleen; HARRISON, Bryce Alden; RAWLINS, David Brent; STROBEL, Eric; ZAMBROWICZ, Brian; WO2014/81660; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

New learning discoveries about 1-Amino-1-cyclopentanecarboxamide

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17193-28-1.

To a solution of 1-aminocyclopentane-1-carboxamide (1.00 g, 7.80 mmol) in DCM (16 mL) was added TEA (2.72 mL, 19.50 mmol). The mixture was cooled to 0 C with an ice bath. Propionyl chloride (1.011 g, 10.92 mmol) in DCM (4 mL) was added dropwise to the stirred solution, and the reaction mixture was at RT for 18 hours. The reaction was diluted with 0 and DCM. The organic phase was collected. The aqueous phase was extracted (2X) with DCM. The combined organic phase was washed with brine, dried over sodium sulfate and concentrated to give Intermediate 112a (0.586 g, 3.18 mmol, 40.8 % yield) as a solid. LC-MS (Method A2) RT =0.46 min, MS (ESI) m/z: 185.1 (M+H)+. 1H NMR (400 MHz, CDCl3) delta 9.37 – 9.15 (m, 2H), 8.71 (br d, J=0.9 Hz, 1H), 2.42 (q, J=7.4 Hz, 2H), 2.39 – 2.29 (m, 2H), 1.85 – 1.68 (m, 4H), 1.67 – 1.58 (m, 2H), 1.14 – 1.10 (m, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17193-28-1.

New learning discoveries about 17193-28-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopentanecarboxamide, and friends who are interested can also refer to it.

General procedure: 1-amino-cyclopentanecarboxamide (3) (8.0 g, 62.5 mmol) was acylated with alkyl acyl chloride (93.7 mmol) and triethylamine (17.3 mL, 125.0 mmol) in 50 mL dichloromethane(DCM) at 0 C.After the reaction was completed, the resulting mixture was addedwith 30 mLwater, and extracted with DCM (25 mL 3). The organiclayer was dried over MgSO4. After filtration, the solvent wasremoved under reduced pressure. The residue was dissolved in50 mL MeOH and then 50 mL 10 M KOH was added slowly. Themixturewas refluxed for 3 h. After cooled to room temperature, themixture was added 50 mL H2O and extracted with DCM(30 mL 4). The organic layer was dried over MgSO4, the solventwas removed under reduced pressure. The resulting residue waspurified by CC to give 5a-d.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopentanecarboxamide, and friends who are interested can also refer to it.

Reference:
Article; Bao, Xiaolu; Zhu, Weibo; Yuan, Weidong; Zhu, Xingbo; Yan, Yijia; Tang, Hesheng; Chen, Zhilong; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 115 – 127;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sources of common compounds: 17193-28-1

Electric Literature of 17193-28-1, A common heterocyclic compound, 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, molecular formula is C6H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sources of common compounds: C6H12N2O

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.

Application of 17193-28-1

The synthetic route of 17193-28-1 has been constantly updated, and we look forward to future research findings.

Related Products of 17193-28-1, These common heterocyclic compound, 17193-28-1, name is 1-Amino-1-cyclopentanecarboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: HATU (90 mg, 0.24 mmol) was added to a solution of 1g (60 mg, 0.19) in DMA (0.75 mL) at 0 C. After 20 min, tert-butylamine (20 mg, 0.28) and DIPEA (50 mg, 0.38 mmol) in DMA (0.4 mL) were added. The reaction mixture was stirred at rt for 20 hrs. The reaction mixture was quenched with aqueous TFA (4%, 0.4 mL), then, extracted with EtOAc (10 mL). The organic layer was washed with water and brine, concentrated in vacuo, then, purified by reverse phase chromatography eluted with ACN and water, and dried using lyophilization to afford the title product as white solid. ESI-MS, m/z 360 (MH)+.

The synthetic route of 17193-28-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VenatoRx Pharmaceuticals, Inc.; BURNS, Christopher J.; COBURN, Glen; LIU, Bin; YAO, Jiangchao; BENETATOS, Christopher; BOYD, Steven A.; CONDON, Stephen M.; HAIMOWITZ, Thomas; US2019/375708; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Continuously updated synthesis method about 17193-28-1

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17193-28-1 as follows. Safety of 1-Amino-1-cyclopentanecarboxamide

N,N-Diisopropylethylamine (0.77 mL, 4.40 mmol) was added to a solution of commercially available ((S)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid, 4 (1 g, 2.2 mmol), 1-aminocyclopentanecarboxamide, 9 (0.282 g, 2.2 mmol) and HATU (1.255 g, 3.30 mmol) in dry acetonitrile (20 mL) at room temperature under Argon atmosphere and the resulted reaction mixture was stirred under the same conditions for 2h. The progress of the reaction was monitored by TLC. Solvent was evaporated under reduced pressure and the crude product was purified on Teledyne Isco Combiflash Rf purification machine to provide (9H-fluoren-9-yl)methyl tert-butyl (5-((1-carbamoylcyclopentyl)amino)-5-oxopentane-1,4-diyl)(S)-dicarbamate, 10 (1.18 g, 95%) as a colorless solid. ESI-MS m/z: 565.3 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta 8.02 (s, 1H, NH), 7.89 (d, J=7.4 Hz, 2H, ArH), 7.67 (d, J=7.4 Hz, 2H, ArH), 7.43-7.27 (m, 5H, ArH, NHFmoc), 7.02 (d, J=6.2 Hz, 1H, NHBoc), 6.87 (bs, 1H, CONH2), 6.85 (bs, 1H, CONH2), 4.28 (d, J=6.1 Hz, 2H, FmocCH2), 4.20 (t, J=6.8 Hz, 1H, FmocCH), 3.80 (q, J=6.8 Hz, 1H, NHCH), 2.96 (q, J=6.3 Hz, 2H, CH2NHFmoc), 2.12-1.83 (m, 4H, CH2), 1.65-1.30 (m, 17H, CH2, Boc).

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SOUTHERN RESEARCH INSTITUTE; UAB RESEARCH FOUNDATION; Suto, Mark J.; Gupta, Vandana; Mathew, Bini; Murphy-Ullrich, Joanne; (105 pag.)US2019/127420; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Simple exploration of 17193-28-1

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.

To a solution of l-aminocyclopentane-l-carboxamide (0.500 g, 3.90 mmol) in DCM (16 mL) was added TEA (1.359 mL, 9.75 mmol). The mixture was cooled with an ice bath. Butyryl chloride (0.572 mL, 5.46 mmol) in DCM (4 mL) was added dropwise to the stirred solution, and the reaction mixture was at RT for 18 hours. The reaction was diluted with 0 and DCM. The organic phase was collected. The aqueous phase was extracted (2X) with DCM. The combined organic phase was washed with brine, dried over sodium sulfate, and concentrated to give Intermediate 114a (0.300 g, 1.513 mmol, 38.8 % yield) as a solid. LC-MS (Method A2) RT =0.54 min, MS (ESI) m/z: 199.1 (M+H)+. H NMR (400 MHz, CDC13) delta 7.15 – 6.86 (m, 2H), 5.38 – 5.27 (m, 1H), 2.28 – 2.18 (m, 2H), 2.14 – 2.07 (m, 2H), 1.98 – 1.89 (m, 2H), 1.75 – 1.65 (m, 4H), 1.62 – 1.56 (m, 2H), 0.90 – 0.87 (m, 3H).

According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.