Category: 167316-28-1

On January 4, 2002, Taran, Frederic; Gauchet, Cecile; Mohar, Barbara; Meunier, Stephane; Valleix, Alain; Renard, Pierre Yves; Creminon, Christophe; Grassi, Jacques; Wagner, Alain; Mioskowski, Charles published an article.Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide The title of the article was Communications: High-throughput screening of enantioselective catalysts by immunoassay. And the article contained the following:

Immunoassay techniques are demonstrated for anal. of catalytic activity of a combinatorial library of enantioselective reduction catalysts. By using an antibody that binds indiscriminately to the two enantiomers of the reduction product, the yield of the reaction can be calculated, and subsequently employing an enantiospecific antibody the enantiomeric excess can be determined This method was demonstrated on a combinatorial library of reduction catalyst prepared by combining a set of 22 chiral diamine-based ligands, e.g., I, with four different metal species. As a model reaction, the enantioselective reduction of benzoyl formic acid to (S)-mandelic acid was studied identifying the optimal catalyst as a combination of [RuCl2(p-cym)]2 with the chiral diamine ligand I. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

The Article related to combinatorial library enantioselective reduction catalyst, high throughput immunoassay screening catalyst library, benzoyl formic acid enantioselective reduction, mandelic acid stereoselective preparation and other aspects.Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 4, 2012, Hou, Wenduan; Zheng, Bo; Chen, Jun; Peng, Yungui published an article.COA of Formula: C15H15F3N2O2S The title of the article was Asymmetric Synthesis of Polysubstituted 4-Amino- and 3,4-Diaminochromanes with a Chiral Multifunctional Organocatalyst. And the article contained the following:

A series of multifunctional catalysts with two chiral diaminocyclohexane units were developed and successfully applied in the asym. oxa-Michael-aza-Henry cascade reaction of salicylaldimines with nitroolefins. This approach provides a simple and efficient entry to polysubstituted chiral 4-aminobenzopyrans with three consecutive stereocenters and in high yield (up to 97%) with excellent stereoselectivity (up to 98% ee and >99:1 dr). Facile access to the nonsym. optically pure 3,4-diaminochromanes was also obtained. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).COA of Formula: C15H15F3N2O2S

The Article related to nitroolefin salicylaldimine chiral diaminocyclohexane thiourea asym michael henry, aminochromane stereoselective preparation, chiral diaminocyclohexane thiourea enantioselective diastereoselective michael henry catalyst and other aspects.COA of Formula: C15H15F3N2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 21, 2001, Mohar, Barbara; Valleix, Alain; Desmurs, Jean-Roger; Felemez, Marc; Wagner, Alain; Mioskowski, Charles published an article.Electric Literature of 167316-28-1 The title of the article was Highly enantioselective synthesis via dynamic kinetic resolution under transfer hydrogenation using Ru(η6-arene)-N-perfluorosulfonyl-1,2-diamine catalysts: a first insight into the relationship of the ligand’s pKa and the catalyst activity. And the article contained the following:

β-(3,4-Dimethoxyphenyl)serine Me ester was obtained in high diastereomeric and enantiomeric excesses under transfer hydrogenation using chiral Ru(η6-arene)-N-perfluorosulfonyl-1,2-diamine catalysts. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Electric Literature of 167316-28-1

The Article related to serine dimethoxyphenyl methyl ester enantioselective synthesis ruthenium biphosphane catalyst, keto amino acid dynamic kinetic resolution catalytic transfer hydrogenation, ruthenium biphosphane catalyst activity pk basicity acidity and other aspects.Electric Literature of 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 12, 2000, Matsubara, Koki; Kida, Hitoshi published a patent.HPLC of Formula: 167316-28-1 The title of the patent was Method for the preparation of tricyclic amino alcohol derivatives through azides. And the patent contained the following:

Tricyclic amino alc. derivatives represented by general formula [I; wherein R1 is lower alkyl or benzyl; *1 represents an asym. carbon atom; R2 is hydrogen, halogeno or hydroxyl; and A is a substituent represented by general formula Q or Q1 (wherein X is NH, O, or S; R5 is hydrogen, hydroxyl, amino, or acetylamino; and *2 represents an asym. carbon atom when R5 is not hydrogen)] are prepared via asym. reduction of phenacyl azides (II; R21 is hydrogen, halogeno or (un)protected hydroxyl; R3 is hydrogen or amino-protecting group; and R1 is lower alkyl or benzyl) to chiral azido alcs. (III) or amino alcs. (IV; R21, R1, R3 are same as above). This process makes it possible to prepare the derivatives I by a short, easy, inexpensive, and practical production process excellent in industrial workability. Compounds I are useful in the treatment and prevention of diabetes, obesity, hyperlipidemia, and so on (no data). Thus, 58 mg [(S,S)-N-methanesulfonyl-1,2-diphenylethylenediamine](p-cymene)ruthenium (preparation given) was added to a solution of 3.6 g 2-azido-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanone (preparation given) in 2.5 mL formic acid/triethylamine solution (Fluka) in 6.5 mL THF and stirred at 5° for 43 h to give 95.0% (R)-2-azido-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanol (94.2 %e.e.). In another example, 2-amino-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanone hydrochloride (1.0 g) and 2 μL Et3N were added to a solution of 133 mg chloro(1,5-cyclooctadiene)rhodium(II) dimer and 397 mg (2R,4R)-N-(tert-butoxycarbonyl)-4-dicyclohexylphosphino-2-diphenylphosphinopyrrolidine and stirred under hydrogen atm. at room temperature for 24 h to give 94.0% (R)-2-amino-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanol (V). Reductive benzylation of V with benzaldehyde in the presence of Pt2O under hydrogen atm. at room temperature for 15 h followed by amidation with (9H-carbazol-2-yloxy)acetic acid using DCC in THF at room temperature for 24 h, borane reduction in THF, and hydrogenolysis over 10% Pd-C in MeOH gave (R)-2-[N-[2-(9H-carbazol-2-yloxy)]ethyl]amino-1-(4-hydroxy-3-methylsulfonylaminophenyl)ethanol. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).HPLC of Formula: 167316-28-1

The Article related to tricyclic amino alc preparation treatment diabetes obesity hyperlipidemia, asym reduction phenacyl azide, ruthenium complex asym reduction catalyst, carbazolyloxyethylaminophenylethanol preparation antidiabetic, phenylethanolamine carbazolyloxyethyl preparation antidiabetic and other aspects.HPLC of Formula: 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics