Application of 167216-30-0, The chemical industry reduces the impact on the environment during synthesis 167216-30-0, name is tert-Butyl (3-hydroxybutyl)carbamate, I believe this compound will play a more active role in future production and life.
Step 2: Synthesis of tert-butyl 6-methyl-1,2,3-oxathiazinane-3-carboxylate 2-oxideTo a stirred solution of thionyl chloride (2.0 mL, 27.9 mmol) in acetonitrile (15 mL) cooled to -45 C is added a solution of tert-butyl (3-hydroxybutyl)carbamate (2.1 g, 11.2 mmol) in acetonitrile (20 mL) by syringe over 10 min, keeping the internal temperature below -40 C. 4-Dimethylaminopyridine (136 mg, 1.1 mmol) is added followed by the dropwise addition of pyridine (4.5 mL, 55.8 mmol, keeping the temperature below -40 C. The addition takes 90 min. Ethyl acetate (50mL) is added to the suspension and the mixture is filtered at -35 C to remove the solid and the solid which is washed with EtOAc before it is discarded. The filtrates are combined, and saturated Na2HP04 solution (20 mL) is added. The mixture is stirred vigorously for 30 min and the organic layer is separated, washed with 1M NaHS04 to remove residual pyridine, dried (MgS04) and concentrated to afford the title compound (2.52 g, 96%) as an oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (3-hydroxybutyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong; WO2011/71716; (2011); A1;,
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