Category: 164332-88-1

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 164332-88-1 as follows. Quality Control of tert-Butyl (2-(2-bromoethoxy)ethyl)carbamate

Example 5-3-1 Preparation of tert-butyl (2-{2-[{5-(2-{2-[(tert- butoxycarbonyl)amino]ethoxy}ethoxy)-2-[1 -(4-ethoxy-2,6-difluorobenzyl)-1 H-indazol-3- yl]pyrimidin-4-yl}(pyridi -4-yl)amino]ethoxy}ethyl)carbamate35 mg 2-[1 -(4-ethoxy-2,6-difluorobenzyl)-1 H-indazol-3-yl]-4-(pyridin-4-ylamino)- pyrimidin-5-ol 5-1-1 (0.074 mmol, 1.0 eq.) was dissolved in 0.6 mL DMF. 31 mg potassium carbonate (0.22 mmol, 3.0 eq.) and 20 mg tert-butyl [2-(2- bromoethoxy)ethyl]carbamate 5-2-1 (0.074 mmol, 1 .0 eq.) were added. The reaction mixture was stirred at room temperature over night. 20 mg tert-butyl [2-(2- bromoethoxy)ethyl]carbamate 5-2-1 (0.074 mmol, 1 .0 eq.) was added and the reaction mixture was stirred for 2.5 h at room temperature. Butanone was added and the organic layer was washed with brine. The aqueous layer was extracted with butanone. The combined organic layers were dried with a waterresitent filter and concentrated in vacuo. The crude product was purified by flash chromatography to provide the 85% pure target compound: 20 mg, 0.03 mmol, 34%.retention time: 1 .20 minMS ES+: 662.3 [M+H]+

According to the analysis of related databases, 164332-88-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; MENGEL, Anne; LERCHEN, Hans-Georg; MUeLLER, Thomas; BAeRFACKER, Lars; HITCHCOCK, Marion; CLEVE, Arwed; BRIEM, Hans; SIEMEISTER, Gerhard; BONE, Wilhelm; FERNANDEZ-MONTALVAN, Amaury Ernesto; SCHROeDER, Jens; MOeNNING, Ursula; HOLTON, Simon; (224 pag.)WO2016/42080; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 164332-88-1, name is tert-Butyl (2-(2-bromoethoxy)ethyl)carbamate, A new synthetic method of this compound is introduced below., Quality Control of tert-Butyl (2-(2-bromoethoxy)ethyl)carbamate

General procedure: A mixture of the alkyl halide, nitrogen-containing compound and excess base (NaH for compounds 80 and 81, Cs2CO3 for other compounds) in DMF was stirredat 60 C for 30 min. The reaction was quenched with water and extracted with EA. The organic layer was washed with water and brine, concentrated and purified by column chromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ngo, Van T.H.; Hoang, Van-Hai; Tran, Phuong-Thao; Ann, Jihyae; Cui, Minghua; Park, Gyungseo; Choi, Sun; Lee, Jiyoun; Kim, Hee; Ha, Hee-Jin; Choi, Kwanghyun; Kim, Young-Ho; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 26; 5; (2018); p. 1035 – 1049;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics