Adding a certain compound to certain chemical reactions, such as: 1628-29-1, name is 1-(10H-Phenothiazin-10-yl)ethanone, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1628-29-1, Application In Synthesis of 1-(10H-Phenothiazin-10-yl)ethanone
Under argon atmosphere,Firstly, NaOH and triethylboron are stirred to form a transparent clear solution at room temperature.The concentration is 1M/L;Then,The above triethylboron solution was successively treated with 10umol (2mol%),Amide substrate 5mmol,Triethoxysilane or polymethylhydrogensiloxane 15mmol,MTBE 2mL added to the 10mL sealed tube,It is heated and stirred in an 80C oil bath for 6 hours.The reaction is over,Exposing the reaction to air quenching,The amine product is then separated directly by column chromatography.According to the results of column chromatography separation, when using triethoxysilane or polymethylhydrogensiloxane (PMHS),The yield of the target product was:
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(10H-Phenothiazin-10-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Taizhou University; Yao Wubing; Li Rongrong; Jiang Huajiang; (10 pag.)CN107337573; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics