Synthetic Route of 162576-01-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 162576-01-4, name is Benzyl (2-aminoethyl)(methyl)carbamate hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.
Boc-Arg (Pbf) -OH (16.0 g, ca. 30.4 mmol) in DMF (150 mL)Compound CA solution of hydrochloride (8.2 g, 33.4 mmol) and DIEA (16.9 mL, 97.2 mmol) was cooled in an ice bath followed by a solution of HATU (13.8 g, 36.4 mmol) dropwise In 20 minutes. The temperature of the reaction mixture was raised to ambient temperature and stirring was continued for an additional hour. The reaction mixture was diluted with EtOAc (1 L) and extracted with water (3 ¡Á 200 mL) and brine (200 mL). The organic layer was dried over MgSO 4 and evaporated to give compound D (24.4 g, yield exceeding the quantitative value) as a yellowish oil.
The chemical industry reduces the impact on the environment during synthesis Benzyl (2-aminoethyl)(methyl)carbamate hydrochloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SIGNATURE THERAPEUTICS INCORPORATED; JENKINS, THOMAS E; Husfeld, Craig O; Seroogy, Julie D; Wray, Jonathan W; (162 pag.)JP2016/41698; (2016); A;,
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