Category: 158580-55-3

Extracurricular laboratory: Synthetic route of 158580-55-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-chloro-4-(methylsulfonamido)benzoate, its application will become more common.

Application of 158580-55-3,Some common heterocyclic compound, 158580-55-3, name is Methyl 2-chloro-4-(methylsulfonamido)benzoate, molecular formula is C9H10ClNO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 165 4-(N-(2-(lH-pyrrol-l-yl)ethyl)methylsulfonamido)-2-chloro-N-(4-chloro-3- (pyridin-2-yl)phenyl)b enzamide 200 muL of l-(2-bromoethyl)-lH-pyrrole and 556 mg of Cesium Carbonate were added to 150 mg of methyl 2-chloro-4-(methylsulfonamido)benzoate in DMF and stirred at room temperature for 16 hours. The reaction mixture was extracted in Ethyl Acetate twice with saturated bicarbonate and once with brine, dried over Magnesium Sulfate, filtered and concentrated to give methyl 4-(N-(2- (lH-pyrrol-l-yl)ethyl)methylsulfonamido)-2-chlorobenzoate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-chloro-4-(methylsulfonamido)benzoate, its application will become more common.

Reference:
Patent; GENENTECH, INC.; CURIS, INC.; WO2009/126863; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics