154748-63-7 Archives - Amides-buliding-blocks

13-Sep-21 News Discovery of 154748-63-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (3-hydroxycyclobutyl)carbamate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154748-63-7, name: tert-Butyl (3-hydroxycyclobutyl)carbamate

c) tert-butyl (3-tosyl-cyclobutyl)-carbamate18.7 g (100 mmol) tert-butyl (3-hydroxy-cyclobutyl)-carbamate and 12.1 g (120 mmol) triethylamine are placed in 500 mL chloroform. 20.5 g (105 mmol) tosyl chloride, which is dissolved in 150 mL chloroform, is added dropwise to this solution at 00C with stirring. Then the reaction mixture is allowed to come up to 200C and stirred for a further 2 h. The organic phase is washed successively with water, with dilute hydrochloric acid, with sodium hydrogen carbonate solution and again with water. The organic phase is dried on magnesium sulphate and the solvent is eliminated in vacuo. Yield: 28.3 g MS (ESI): 342 (M +H)+

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2007/115999; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Share a compound : tert-Butyl (3-hydroxycyclobutyl)carbamate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (3-hydroxycyclobutyl)carbamate, its application will become more common.

Related Products of 154748-63-7,Some common heterocyclic compound, 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, molecular formula is C9H17NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 2 (4g 21.6 mmol) was dissolved in HCI/EA (25 mL). The mixture was stirred at RT for 2 h. The solvent was removed to give the product.

Reference:
Patent; NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.; WO2013/96744; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Introduction of a new synthetic route about 154748-63-7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 154748-63-7, A common heterocyclic compound, 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, molecular formula is C9H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of tert-butyl (1S,3R)-3-hydroxycyclopentylcarbamate (0.50g, 2.5mmol),4-(trifluoromethyl)phenol (0.49g, 3mmol) and triphenylphosphine (0.98g, 3.75mmol) in anhydrous THF (8mL) was dropwise added DIAD (0.98mL, 4.68mmol) in anhydrous THF (7mL). The reaction solution was stirred at room temperature overnight. The resulting solution was concentrated in vacuo, and the residue was subjected to flash column chromatography on silica gel (eluting with EtOAc-heptane by a gradient of EtOAc from 4% to 32%) to deliver title compound as colorless crystals (0.63g, 73%)

Reference:
Article; Aktas, Bertal H.; Bohm, Andrew; Chorev, Michael; Du, Ronghui; Halperin, Jose; Reis Monteiro dos Santos, Guilherme Rodrigo; Yefidoff-Freedman, Revital; Zhang, Qingwen; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A new synthetic route of C9H17NO3

Statistics shows that tert-Butyl (3-hydroxycyclobutyl)carbamate is playing an increasingly important role. we look forward to future research findings about 154748-63-7.

Electric Literature of 154748-63-7, These common heterocyclic compound, 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tert-butyl (3 -hydroxycyclobutyl)carbamate (see PREPARATION 4B; 1.08 g, 3.8 mmol) in DMF (20 mL) at RT was added sodium hydride (60% wt in mineral oil) (0.18 g, 7.6 mmol). The mixture was stirred at RT for 10 min and then 3-Bromo-2-fluoro- pyridine (665 mg, 3.8 mmol) was added. The reaction mixture was stirred at RT for lh and then diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were washed with water (10 mL) and brine (10 mL), dried over Na2S04, and filtered. The filtrate was evaporated in vacuo and the residue was purified by flash columnchromatography on silica gel (5% to 30%> EtOAc in hexanes) to give tert-butyl ((lS,3S)-3-((3- bromopyridin-2-yl)oxy)cyclobutyl)carbamate (391 mg, 1.14 mmol, 30%> yield ) as white solid. ESI-MS (M+l): 343 calc. for Ci4Hi9BrN203 342.

Statistics shows that tert-Butyl (3-hydroxycyclobutyl)carbamate is playing an increasingly important role. we look forward to future research findings about 154748-63-7.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The origin of a common compound about tert-Butyl (3-hydroxycyclobutyl)carbamate

The chemical industry reduces the impact on the environment during synthesis tert-Butyl (3-hydroxycyclobutyl)carbamate. I believe this compound will play a more active role in future production and life.

Application of 154748-63-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows.

3-(tert-butoxycarbonylamino)cyclobutyl 4-methylbenzenesulfonate 3-(tert-butoxycarbonyl amino)cyclobutyl 4-methylbenzenesulfonate was prepared from tert-butyl 3-hydroxycyclobutylcarbamate and 4-methylbenzene-1-sulfonyl chloride using Method M. The product was purified by flash chromatography eluting with EtOAc in hexane (0% to 17% gradient) to yield tert-butyl N-(3-[[(4-methylbenzene)sulfonyl]oxy]cyclobutyl)carbamate as a yellow solid (915 mg, 53%).

Reference:
Patent; Merck Patent GmbH; SHERER, Brian A.; KARRA, Srinivasa; XIAO, Yufang; (407 pag.)US2016/376283; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of C9H17NO3

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2007/115999; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Continuously updated synthesis method about 154748-63-7

The synthetic route of 154748-63-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, A new synthetic method of this compound is introduced below., name: tert-Butyl (3-hydroxycyclobutyl)carbamate

Step B: Tert-butyl 3-fluorocyclobutylcarbamate. To a solution tert-butyl 3-hydroxycyclobutyl – carbamate ( 1 g, 5.35 mmol) in dry DCM (20 mL) at -70 C was added DAST dropwise (l g, 0.85 mL, 1 .17 eq) under the atmosphere of N2. The mixture was then slowly warmed to room temperature and stirred overnight. The resulting mixture was washed with diluted aq. NaHC03. The organic layer was dried over anhydrous Mg2S04 and concentrated. The residue was purified by flash chromatography using petroleum ether / EtOAc (V:V, 20: 1 to 2: 1 ) as eluent to afford a white solid as the desired product. MS : 190.1 (M+ l )+.

The synthetic route of 154748-63-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding; WO2015/10297; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

New downstream synthetic route of 154748-63-7

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 154748-63-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H17NO3

To a solution of (3-hydroxy-cyclobutyl)-carbamic acid tert-butyl ester (2.5 g, 13.3 mmol) in THF (40 mL) were added CS2CO3 (8.6 g, 26.6 mmol) and 5-bromo-2,4- dichloro- pyrimidine (3 g, 13.3 mmol). The reaction mixture was heated at reflux overnight. The reaction mixture was filtered and concentrated, diluted with EtOAc and water. The aqueous phase was extracted with EtOAc (3 x 100 mL) and the combined organic extracts were washed with brine (60 mL), dried over MgSO*}, filtered, and concentrated. Purification by flash column chromatography on silica gel to give the product (4.75 g, 12.6 mmol, yield: 95%). ESI-MS (M+l): 378 calc. for CisHnBrClNsOs 377.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 154748-63-7.