Category: 15441-10-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15441-10-8, name is 3-(Aminosulfonyl)propanoic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H7NO4S

3-sulfamoylpropionic acid (Compound 1) (15.0 g, 97.94 mmol) and 2,4-dihydroxybenzoic acid (Compound 2)(10.2 g, 66.18 mmol) were dissolved in acetic anhydride (22.6 mL). Triethylamine (13.2 mL) was carefully addedto the mixture, andthe mixture was heated for 4 hr.After the reaction, it was cooled and diluted with water.The precipitated product was filtered and washed with aqueous methanol togive (7-hydroxy-2-oxo-2H-chromen-3-yl)methanesulfonamide (Compound 3), 21.2 g, yield 85%.

According to the analysis of related databases, 15441-10-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zeng Qingqiang; (12 pag.)CN108586445; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 15441-10-8, name is 3-(Aminosulfonyl)propanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-(Aminosulfonyl)propanoic acid

General procedure: To a solution of 3-(4-((2-aminopropyl)thio)-1 ,2,5-oxadiazol-3-yl)-4-(3-(difluoromethyl)-4- fluorophenyl)-1 ,2,4-oxadiazol-5(4H)-one hydroiodide (Int 102) (416 mg, 0.81 mmol), HATU (462 mg, 1 .22 mmol) and Et3N (245 mg, 2.43 mmol) in DMF (8 mL) 2- sulfamoylacetic acid (135 mg, 0.97 mmol) was added and the mixture was stirred at rt overnight. EtOAc (20 mL) was added and the mixture was extracted with water (2 x 20 mL). The combined organic layers were dried over anhydrous Na2S0 , filtered and concentrated to dryness. The residue was purified by column chromatography to give the title compound as a white solid.

The synthetic route of 3-(Aminosulfonyl)propanoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX DISCOVERY VERWALTUNGS-GMBH; STEENECK, Christoph; KINZEL, Olaf; ANDERHUB, Simon; HORNBERGER, Martin; KLEYMANN, Gerald; HOFFMANN, Thomas; (191 pag.)WO2018/83241; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics