Category: 152192-95-5

Synthetic Route of 152192-95-5, These common heterocyclic compound, 152192-95-5, name is tert-Butyl ethyl(2-hydroxyethyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Stage 2: [2-(1,3-Dihydroisoindol-2-yl)ethyl]ethylcarbamic acid tert-butyl ester: A solution of 10.2 g of diethyl azodicarboxylate in 60 ml of THF is added dropwise to a mixture containing 11.92 g of ethyl-(2-hydroxyethyl)carbamic acid tert-butyl ester, 15.2 g of isoindole-1,3-dione and 8.6 g of triphenylphosphine in 40 ml of THF. The medium is kept stirring overnight at room temperature and then concentrated to dryness. The medium is taken up in 100 ml of ethyl ether, the precipitate formed is removed by filtration. The filtrate is concentrated and chromatographed on a silica column (heptane in a gradient up to 3% ethyl acetate). 14 g of expected product are obtained.

Statistics shows that tert-Butyl ethyl(2-hydroxyethyl)carbamate is playing an increasingly important role. we look forward to future research findings about 152192-95-5.

Reference:
Patent; sanofi-aventis; US2008/269170; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 152192-95-5, name is tert-Butyl ethyl(2-hydroxyethyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152192-95-5, COA of Formula: C9H19NO3

To a mixture of tert-butyl ethyl(2-hydroxyethyl)carbamate (1.89 g) obtained in Reference Example 19 and ethyl acetate (20 mL) were added acetic anhydride (1.04 mL), pyridine (0.89 mL) and 4-dimethylaminopyridine (0.061 g). After stirring at room temperature for 3 hrs., ethyl acetate (50 mL) was added, and the mixture was washed with water (50 mL), a 5% aqueous citric acid solution (50 mL) and saturated brine (50 mL). After drying over anhydrous magnesium sulfate, the mixture was concentrated under reduced pressure. A 4N hydrogen chloride – ethyl acetate solution (10 mL) was added to the residue, and the mixture was stirred at room temperature for 1 hr. Ethyl acetate (10 mL) and diethyl ether (20 mL) were added, and the precipitated solid was collected by filtration. The solid was dried under reduced pressure to give the title compound (1.54 g) as a white solid.1H-NMR(DMSO-d6) : 1.22 (3H,t,J=7.3Hz), 2.07 (3H,s), 2.95(2H,q,J=7.3Hz), 3.15(2H,t,J=5.3Hz), 4.24-4.30(2H,m), 9.17 (2H,br).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl ethyl(2-hydroxyethyl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1607088; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics