Category: 15029-36-4

Kong, Lingbin published the artcileMulti-component solvent-free cascade reaction of 2-cyanoacetamides: regioselective synthesis of pyridin-2-ones bearing quaternary centers, COA of Formula: C5H8N2O, the publication is Green Chemistry (2020), 22(1), 256-264, database is CAplus.

A novel protocol has been constructed for the synthesis of four types of pyridin-2-ones via solvent-free cascade reactions of 2-cyanoacetamides, various ketones, and acetone via multicomponent reactions to prepare target compounds with good to excellent yields. As a result, functionalized pyridin-2-ones bearing quaternary centers, specifically, spiropyridin-2-ones, were generated by piperidine under solvent-free conditions. Also, a double bond has been introduced into the target compounds through aryl substituted 2-cyanoacetamides under the same conditions. The advantages of this approach include no solvents, simple and practical operation (multi-component one-pot), high yields (up to 95%), and a product with potential biol. activity.

Green Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hill, Timothy A. published the artcileInhibition of Dynamin Mediated Endocytosis by the Dynoles-Synthesis and Functional Activity of a Family of Indoles, SDS of cas: 15029-36-4, the publication is Journal of Medicinal Chemistry (2009), 52(12), 3762-3773, database is CAplus and MEDLINE.

Screening identified two bisindolylmaleimides as 100 μM inhibitors of the GTPase activity of dynamin I. Focused library approaches allowed development of indole-based dynamin inhibitors called dynoles. 100-Fold in vitro enhancement of potency was noted with the best inhibitor, 2-cyano-N-octyl-3-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-acrylamide (dynole 34-2), a 1.3 ± 0.3 μM dynamin I inhibitor. Dynole 34-2 potently inhibited receptor mediated endocytosis (RME) internalization of Texas red-transferrin. The rank order of potency for a variety of dynole analogs on RME in U2OS cells matched their rank order for dynamin inhibition, suggesting that the mechanism of inhibition is via dynamin. Dynoles are the most active dynamin I inhibitors reported for in vitro or RME evaluations. Dynole 34-2 is 15-fold more active than dynasore against dynamin I and 6-fold more active against dynamin mediated RME (IC₅₀ ∼15 μM; RME IC₅₀ ∼80 μM). The dynoles represent a new series of tools to better probe endocytosis and dynamin-mediated trafficking events in a variety of cells.

Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Davis, H. Lorne published the artcile2,3-Disubstituted 1,8-naphthyridines as potential diuretic agents. 3. 4- and 7-Phenyl derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is European Journal of Medicinal Chemistry (1985), 20(4), 381-3, database is CAplus.

Naphthyridines I [R = Ph, OH, NH₂; R¹ = cyano, (un)substituted CONH₂, CO₂Me; R², R³ = H, Ph] were prepared Thus, 2-amino-3-benzoylpyridine (II) was cyclized with NCCH₂CONH₂ to give I (R = OH, R¹ = cyano, R² = Ph, R³ = H) (III). Cyclocondensation of II and CH₂(CN)₂ gave I (R = NH₂; R¹ = cyano, R² = Ph, R³ = H), which was hydrolyzed to I (R¹ = CONH₂) (IV). III and IV were as potent diuretics as triamterene, but I (R³ = Ph) were inactive.

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

El-Faham, Ayman published the artcileSynthesis, characterization and anti-proliferation activity of novel cyano oximino sulfonate esters, Name: 2-Cyano-N-ethylacetamide, the publication is Chemical & Pharmaceutical Bulletin (2014), 62(4), 373-378, database is CAplus and MEDLINE.

A series of cyano oximino sulfonate derivatives RS(O)2ON:C(CN)X (R = 4-CH₃C₆H₅, naphthalen-2-yl; X = C₆H₅, C₂H₅NH₂, NH₂, etc). were prepared from the reaction of arylsulfonyl chloride with different cyanoacetamide-based oximes ranging from the simplest unsubstituted amide to analogs containing N-Et (mimicking the Oxyma template), N-piperidinyl and N-morpholinyl chains. In addition, the cyano oximes, N-hydroxybenzimidoyl cyanide and N-hydroxy picolinimidoyl cyanide were also used in the synthesis of cyano oximino sulfonate derivatives The preliminary bioassays showed that some of the title compounds, such as (TsPipOx), (TsPhOX), (NpsPipOx) etc, showed anti-proliferation effect on the mouse fibroblast L929. The calculated IC₅₀-values were ranging between 36.5 μg/mL and 0.235 mg/mL. However the anti-proliferation effects seem to be cytostatic rather than cytotoxic. The compounds only minimize the growth activity without completely killing the cells.

Chemical & Pharmaceutical Bulletin published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

El Hefny, Eman A. published the artcileSynthesis, characterization, antitumor evaluation and molecular docking of some triazolotriazine derivatives, Name: 2-Cyano-N-ethylacetamide, the publication is Journal of Pharma Research (2014), 3(5), 79-87, database is CAplus.

The synthesis of 4-amino-[1,2,4]triazolo[5,1-c][1,2,4]triazine derivatives I (R = CN, COOC₂H₅, CONH₂) using readily available starting materials is described. In this study, six selected derivatives, compounds I (R = CN), II, III, IV (Ar = 4-ClC₆H₄, 2-ClC₆H₄) and V were subjected to a screening system for investigation of their antitumor potency against liver (HEPG2) cell line in comparison to known anticancer drugs, 5-fluorouracil and Doxorubicin. The antitumor activity results indicated that the selected compounds I (R = CN), II, III, IV (Ar = 4-ClC₆H₄, 2-ClC₆H₄) and V derivatives showed growth inhibition activity against the tested cell line but with varying intensities in comparison to 5-fluorouracil and Doxorubicin. Compounds II and III were investigated for the binding affinity of c-Kit tyrosine kinases receptor.

Journal of Pharma Research published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Al-Etaibi, Alya published the artcileThe effect of dispersing agent on the dyeing of polyester fabrics with disperse dyes derived from 1,4-diethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile, Name: 2-Cyano-N-ethylacetamide, the publication is European Journal of Chemistry (2013), 4(3), 240-244, database is CAplus.

1,4-Diethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile (8), is synthesized by reacting Et cyanoacetate with Et amine to produce the amide 4, which when reacted with Et propionylacetate, afforded compound 8. Compound 8 is then coupled with aromatic diazonium salts to give the corresponding arylhydrazono-1,4-diethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile disperse dyes, 11a-d, whose structures were elucidated by using X-ray crystal structure determinations A high temperature dyeing method was employed to apply these dyes for polyester fabrics. The relationship between dyeing properties and the concentration of dispersing agent present in a dye bath is evaluated.

European Journal of Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jackson, Grayson L. published the artcileDesigning Stress-Adaptive Dense Suspensions Using Dynamic Covalent Chemistry, Synthetic Route of 15029-36-4, the publication is Macromolecules (Washington, DC, United States) (2022), 55(15), 6453-6461, database is CAplus and MEDLINE.

The non-Newtonian behaviors of dense suspensions are central to their use in technol. and industrial applications and arise from a network of particle-particle contacts that dynamically adapt to imposed shear. Reported herein are studies aimed at exploring how dynamic covalent chem. between particles and the polymeric solvent can be used to tailor such stress-adaptive contact networks, leading to their unusual rheol. behaviors. Specifically, a room temperature dynamic thia-Michael bond is employed to rationally tune the equilibrium constant (K_eq) of the polymeric solvent to the particle interface. It is demonstrated that low K_eq leads to shear thinning, while high K_eq produces antithixotropy, a rare phenomenon where the viscosity increases with shearing time. It is proposed that an increase in K_eq increases the polymer graft d. at the particle surface and that antithixotropy primarily arises from partial debonding of the polymeric graft/solvent from the particle surface and the formation of polymer bridges between particles. Thus, the implementation of dynamic covalent chem. provides a new mol. handle with which to tailor the macroscopic rheol. of suspensions by introducing programmable time dependence. These studies open the door to energy-absorbing materials that not only sense mech. inputs and adjust their dissipation as a function of time or shear rate but also can switch between these two modalities on demand.

Macromolecules (Washington, DC, United States) published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Synthetic Route of 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chavan, Sunil S. published the artcileIonic liquid-catalyzed 4,6-disubstituted-3-cyano-2-pyridone synthesis under solvent-free conditions, Safety of 2-Cyano-N-ethylacetamide, the publication is Catalysis Letters (2011), 141(11), 1693-1697, database is CAplus.

A green protocol for the synthesis of 4,6-disubstituted-3-cyano-2-pyridones from cyanoacetamides and 1,3-dicarbonyl compounds or chalcones using guanidine-based ionic liquid as catalyst was developed. In solvent-free conditions at 30 °, 1,1,3,3-tetramethylguanidine lactate had the highest catalytic activity among the ionic liquids including 1,1,3,3-tetramethylguanidine acetate, 1,1,3,3-tetramethylguanidine propionate, 1,1,3,3-tetramethylguanidine n-butyrate, and 1,1,3,3-tetramethylguanidine trifluoroacetate. The catalyst was recovered and recycled several times without significant loss of catalytic activity.

Catalysis Letters published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Safety of 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

O’Callaghan, C. N. published the artcileAnticancer agents XIII. Synthesis and antitumor activity of 2-iminochromene derivatives, SDS of cas: 15029-36-4, the publication is Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science (1979), 79B(6), 87-98, database is CAplus.

Iminochromenes I (R = H, 6-OMe, 7-OMe, 6-NO₂, 6,8-Br₂, 8-OEt, 8-OMe; R¹ = H, alkyl, hydroxyalkyl, NHCSNHMe, optionally substituted Ph, anilino, acylamino, morpholino) were prepared by condensing salicylaldehydes with NCCH₂CONHR¹. II (R² = OMe, OEt, OPr, R³ = H; R² = H, R³ = OMe, OEt, OPr) were obtained by condensing salicylaldehydes with 1-cyanoacetyl-3,5-dimethylpyrazole. I, II, and related compounds had antitumor activity. Thus, I (R = 6-OMe, R¹ = H) gave a mean survival time 131% of controls as 108 mg/kg in P 388 lymphocytic leukemia-infected mice.

Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics