Category: 15029-36-4

Devani, M. B. published the artcileSynthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)pyrimidin-7(6H)-one-2(3H)-thiones, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Arzneimittel-Forschung (1977), 27(9), 1652-5, database is CAplus and MEDLINE.

Twenty-six aminothiazolethiones I (R = Et, benzyl, allyl, Ph, tolyl, etc.; R1 = NH2, NHMe, piperidino, morpholino, PhNHNH) were prepared in 40-90% yield by reaction of RNCS with NCCH2CONHR1. Eleven thiazolopyrimidinones II (R = benzyl, tolyl, Ph, Me, Et, R2 = H, Me, Et, Ph, anilino) were prepared in 55-70% yield by reaction of the appropriate I with HC(OEt)2 in Ac2O. I and II were screened for antimicrobial and pharmacol. activities. Maximum antiinflammatory activity was found in I (R = o-tolyl, R1 = morpholino); at 200 mg/kg its activity was almost equal to phenylbutazone at 100 mg/kg. I (R = allyl, R1 = PhNHNH) was the most active antimicrobial of the series. I (R = benzyl, R1 = NH2) was the most potent analgesic.

Arzneimittel-Forschung published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mirkovic, Jelena published the artcileOn the structures of 5-(4-, 3- and 2-methoxyphenylazo)-3-cyano-1-ethyl-6-hydroxy-4-methyl-2-pyridone: An experimental and theoretical study, Name: 2-Cyano-N-ethylacetamide, the publication is Dyes and Pigments (2014), 160-168, database is CAplus.

In this work, a combined exptl. and theor. study on the structures of methoxy substituted 5-phenylazo-3-cyano-1-ethyl-6-hydroxy-4-methyl-2-pyridones has been reported. The dyes under the investigation have been thoroughly characterized. X-ray single-crystal anal. shows that 5-(4-methoxyphenylazo)-3-cyano-1-ethyl-6-hydroxy-4-methyl-2-pyridone crystallizes in the hydrazone form. Quantum chem. calculations of energies, geometrical structure and vibrational wavenumbers of the investigated dyes have been performed using d. functional theory. The optimized geometrical parameters obtained by d. functional theory calculations are in good conformity with the single-crystal data. The fundamental vibrational wavenumbers, as well as their intensities have been calculated and a good agreement between observed and scaled calculated wavenumbers has been achieved. Stability of the mol. arising from hyperconjugative interactions and charge delocalization has been analyzed using natural bond orbital anal. Vibrational, NMR and natural bond orbital anal. confirm that the prepared dyes exist in the hydrazone tautomeric form in the solid state and DMSO solution

Dyes and Pigments published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Reddy, Y. Thirupathi published the artcileSulfamic acid: An efficient, cost-effective, and reusable solid acid catalyst for the synthesis of 1,8-naphthyridines under solvent-free heating and microwave irradiation, COA of Formula: C5H8N2O, the publication is Synthetic Communications (2008), 38(18), 3201-3207, database is CAplus.

An efficient and convenient method is described for the synthesis of 1,8-naphthyridines in excellent yields by condensation of 2-aminonicotinaldehyde with various active methylene compounds in the presence of sulfamate as the catalyst in solvent-free media using both conventional heating and microwave irradiation

Synthetic Communications published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Karteek, S. Durga published the artcileSynthesis and Docking Study of Novel Pyranocoumarin Derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Russian Journal of Organic Chemistry (2021), 57(2), 272-282, database is CAplus.

A new series of fused tricyclic coumarin derivatives I [R¹ = H, Me, Ph, etc.; R² = H, Me, Et] were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by mol. docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compds I.

Russian Journal of Organic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mohammad Shafiee, M. R. published the artcileHighly Efficient and Green Synthesis of Indole and Benzofuran Derivatives via Electrochemical Methods under ECECCC Mechanism, Name: 2-Cyano-N-ethylacetamide, the publication is Journal of the Electrochemical Society (2017), 164(13), G105-G111, database is CAplus.

Electrochem. synthesis of novel benzofuran and indole derivatives was carried out by the electrochem. oxidation of hydroquinone, 4-aminophenol and p-phenylenediamine in the presence of cyanoacetamide and 2-cyano-n-ethylacetamide as nucleophiles in a phosphate buffer solution (PBS) mixed with ethanol as a green solvent using cyclic voltammetry, controlled-potential coulometry, and UV-spectroscopy methods. The oxidized form of hydroquinone, 4-aminophenol, and p-phenylenediamine participate in the 1,4-Michael addition reactions with cyanoacetamides via the ECECCC mechanism for the electrochem. synthesis of new benzofuran and indole derivatives with good yield and high purity under controlled potential conditions. In this method, a carbon rod was used as the anode and the use of toxic and/or hazardous reagents was avoided. The obtained products were characterized after purification by the FTIR, ¹HNMR, ¹³C NMR and elemental anal. The present work led to the development of a facile and environmentally friendly reagent-less electrochem. method with high atom economy and safer waste under green conditions.

Journal of the Electrochemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dey, Dhananjay published the artcileCrystal and molecular structure of 2-amino-3-ethylcarbamoyl-4-methyl-5-ethoxycarbonylthiophene, COA of Formula: C5H8N2O, the publication is Crystal Structure Theory and Applications (2012), 1(3), 92-96, 5 pp., database is CAplus.

The crystal and mol. structure of 2-amino-3-ethylcarbamoyl-4-methyl-5-ethoxycarbonylthiophene was determined from single crystal X-ray diffraction data. The primary focus was to investigate the mol. geometry of this compound in the solid state along with the associated intermol. and intramol. hydrogen bonding and related weak interactions present in this mol. This compound crystallized in the monoclinic space group P2₁/c with cell parameters: a = 8.1344(3) Å, b = 13.7392(4) Å, c = 11.4704(4) Å, β = 100.769(2)° , V = 1259.36(7) ų, D = 1.352 g·cm^-3, Z = 4. The mol. geometry was stabilized by intramol. N-H···O=C and C-H···O interactions along with intermol. C-H···N and C-H···O interactions which contribute towards the stability of the crystal packing.

Crystal Structure Theory and Applications published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Modi, Visha P. published the artcileStudies on synthesis, characterization and solvatochromic effect of novel tris(heteroaryl)bisazo dyes for dyeing polyester fabric, Product Details of C5H8N2O, the publication is Elixir Online Journal (2012), 7192-7201, database is CAplus.

In the present communication novel tris(hetroaryl)bisazo dyes were synthesized by the coupling of various heterocyclic diazonium salt with 1-ethyl-6-hydroxy-4-methyl-2-oxo-5-((4-phenylthiazol-2-yl)diazenyl)-1,2-dihydropyridine-3-carbonitrile. The later compound was synthesized by a new procedure for the synthesis of well known azo pyridone dyes from 2-cyano-N-ethylacetamide, ethyl-3-oxobutanoate and 4-aryl-2-aminothaizole. Structural confirmation of all the synthesized compounds have been accomplished by UV-Visible, FT-IR, 1H-NMR,13C-NMR and mass spectroscopic techniques. Solvent effects on the visible absorption spectra of the dyes were evaluated. The color of the dyes is discussed with respect to the nature of the heterocyclic ring and substituent present therein. All these dyes were applied as disperse dyes on to polyester fabrics and their fastness properties were evaluated.

Elixir Online Journal published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shaik, Jeelan Basha published the artcileSynthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer’s Disease, Name: 2-Cyano-N-ethylacetamide, the publication is Chemical Biology & Drug Design (2016), 88(1), 43-53, database is CAplus and MEDLINE.

Alzheimer’s disease onset and progression are associated with the dysregulation of multiple and complex physiol. processes, and a successful therapeutic approach should therefore address more than one target. In line with this modern paradigm, a series of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene analogs (4a-q) were synthesized and evaluated for their multitarget-directed activity on acetylcholinesterase, butyrylcholinesterase (BuChE), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical, and amyloid-β peptide (Aβ) specific targets for Alzheimer’s disease therapy. Most of the synthesized compounds showed remarkable acetylcholinesterase inhibitory activities in low nM concentrations and good ABTS radical scavenging activity, however, no evidence of BuChE inhibitory activity. Among them, 3-bromobenzylamide derivative N-(3-bromobenzyl)-8-imino-2-oxo-2H,8H-pyrano [2,3-f]chromene-9-carboxamide (4m) exhibited the best acetylcholinesterase inhibitory activity with IC₅₀ value of 13±1.4 nM which is 51-fold superior to galantamine, a reference drug. Kinetic and mol. docking studies indicated (4m) as mixed-type inhibitor, binding simultaneously to catalytic active and peripheral anionic sites of acetylcholinesterase. Five compounds N-cyclohexyl-8-imino-2-oxo-2H,8H-pyrano[2,3-f] chromene-9-carboxamide (4e), 8-imino-9-(morpholine-4-carbonyl)-2H,8H-pyrano [2,3-f]chromen-2-one (4f), N-benzyl-8-imino-2-oxo-2H,8H-pyrano[2,3-f] chromene-9-carboxamide (4g), 8-imino-N-(1-(4-methoxyphenyl)ethyl)-2-oxo-2H,8H- pyrano[2,3-f]chromene-9-carboxamide (4j), and N-(2,4-dimethoxybenzyl)-8-imino-2-oxo-2H,8H- pyrano[2,3-f]chromene-9-carboxamide (4k) have shown 1.4- to 2.5-fold of higher antioxidant activities than trolox. Interestingly, the most active compound (4m) demonstrated dosage-dependent acceleration of Aβ_1-42 aggregation, which may reduce toxicity of oligomers. Overall, these results lead to discovery of fused tricyclic coumarins as promising dual binding site inhibitors of acetylcholinesterase and afford multifunctional compounds with potential impact for further pharmacol. development in Alzheimer’s therapy.

Chemical Biology & Drug Design published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C12H10O4S, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shaik, Jeelan Basha published the artcileSynthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents, Quality Control of 15029-36-4, the publication is European Journal of Medicinal Chemistry (2016), 219-232, database is CAplus and MEDLINE.

A series of fused tricyclic coumarin derivatives bearing iminopyran ring connected to various amido moieties was developed as potential multifunctional anti-Alzheimer agents for their cholinesterase inhibitory and radical scavenging activities. In vitro studies revealed that most of these compounds exhibited high inhibitory activity on acetylcholinesterase (AChE), with IC₅₀ values ranging from 0.003 to 0.357 μM which is 2-220 folds more potent than the pos. control, galantamine. Their inhibition selectivity against AChE over butyrylcholinesterase (BuChE) has increased about 194 fold compared with galantamine. The developed compounds also showed potent ABTS radical scavenging activity (IC₅₀ 7.98-15.99 μM). Specifically, the most potent AChE inhibitor, I (NR¹R² = NHCH₂C₆H₄Br-3) (II), (IC₅₀ 0.003 ± 0.0007 μM) has an excellent antioxidant profile as determined by the ABTS method (IC₅₀ 7.98 ± 0.77 μM). Moreover, cell viability studies in SK N SH cells showed that the compounds I (NR¹R² = NHCH₂C₆H₄Br-2, NHCH₂C₆H₄Br-3, NHCH₂C₆H₄Cl-2, NHCH₂C₆H₄Cl-3, NHCH₂C₆H₄CMe₃-4) (III) have significant neuroprotective effects against H₂O₂-induced cell death, and are not neurotoxic at all concentrations except I (NR¹R² = NHCH₂C₆H₄CMe₃-4) and II. The kinetic anal. of compound II proved that it is a mixed-type inhibitor for EeAChE (K_i1 0.0103 μM and K_i2 0.0193 μM). Accordingly, the mol. modeling study demonstrated that III with a substituted benzyl amido moiety possessed an optimal docking pose with interactions at catalytic active site (CAS) and peripheral anionic site (PAS) of AChE simultaneously and thereby they might prevent aggregation of Aβ induced by AChE. Furthermore, in silico ADMET prediction studies indicated that these compounds satisfied all the characteristics of CNS acting drugs. Most active inhibitor II is permeable to BBB as determined in the in vivo brain AChE activity. To sum up, the multipotent therapeutic profile of these novel tricyclic coumarins makes them promising leads for developing anti-Alzheimer agents.

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C4H6O3, Quality Control of 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rastogi, R. R. published the artcileKetene SS-acetals. Part 10. Reaction of α-oxoketene SS-acetals with N-alkylcyanoacetamides: a new general method for substituted and fused 2,7-dialkyl-8-amino-5-cyano-2,7-naphthyridine-1,6(2H,7H)-diones, Formula: C5H8N2O, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1978), 554-8, database is CAplus.

The reaction of α-oxoketene dithioacetals with NCCH₂CONHR (I; R = Me, Et) in the presence of NaOCHMe₂ gave 25-93% 2,7-naphthyridine derivatives via N-alkylpyridone intermediates. E.g., naphthyridine II was obtained (38%) by reaction of (MeS)₂C:CHCOPh with I (R = Me). (MeS)₂C:CRCN (III; R = Ph, p-ClC₆H₄, CN) gave 46-68% pyridones IV (R = Me, Et, R¹ = Ph, p-ClC₆H₄, CN) under similar conditions, whereas cyclic ketene dithioacetals V (n = 1,2) gave 71-80% fused naphthyridines VI (n = 1, 2, R = Me, Et). Naphthonaphthyridones VII (R = Me, Et; n = 1, R¹ = H, OMe; n = 2, R¹ = H) were obtained in high yield from the reaction of ketene dithioacetals VIII (n = 1, R¹ = H, OMe; n = 2, R = H) with I (R = Me, Et).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics