Category: 15029-36-4

Seng, Florin published the artcile2-Aminocarbonyl-1-hydroxybenzimidazole 3-oxides, Application In Synthesis of 15029-36-4, the publication is Synthesis (1972), 606, database is CAplus.

The 1-hydroxybenzimidazole 3-oxides I (R = H, Cl, Me, OMe; R1 = H, Me, Et, Ph, cyclohexyl) were prepared in 32-92% yield by treating the corresponding benzofuroxans with NCCH2CONHR1 and aqueous NaOH to precipitate the Na salts of I. Acidification of the Na salts yielded free I.

Synthesis published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C15H19BO2, Application In Synthesis of 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sasse, Klaus published the artcile1-Substituted 1,6-dihydro-4-mercapto-6-pyrimidinones and 1,2,3,6-tetrahydro-4-(methylthio)-2,6-pyrimidinediones, Product Details of C5H8N2O, the publication is Justus Liebigs Annalen der Chemie (1976), 768-80, database is CAplus.

RNHCOCH2CSNH2 [R = alkyl, allyl, MeO(CH2)3, Ph, cyclohexyl, PhCHMe, furfuryl] reacted with MeO2CH and Na in EtOH to give 23.1-93.0% pyrimidinones I or EtNHCOCH2CSNH2 reacted with MeO2CH and KOCMe3 in Et2O to give 56% pyridinedicarboxamide II. I were methylated to give 42.2-79.5% III which gave 44.6-73.1% 5-halo derivatives with SOCl2 or Br. Treating RNHCOCH2C(SMe):NH·HI with EtO2Cl (55.-91.4% yields) and cyclizing the RNHCOCH:C(SMe)NHCO2Et in alk. solution gave 23.9-73.3% pyrimidinediones IV. These were halogenated in the 5 position (48.4-77.5% yields) and methylated (MeI) on the N3 position (70.4-81.4% yields).

Justus Liebigs Annalen der Chemie published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hoerlein, Ulrich published the artcileNonsymmetric N-substituted bispidine (3,7-diazabicyclo[3.3.1]nonane. I, Formula: C5H8N2O, the publication is European Journal of Medicinal Chemistry (1977), 12(4), 301-5, database is CAplus.

Bispidine derivatives I [R = R1 = Me, RR1 = (CH2)5, R2 = Me, Et, CH2Ph, R3 = H; RR1 = (CH2)4, R2 = Me, Et, R3 = H] were prepared by condensing RR1C:C(CN)CO2Et with R2NHCOCH2CN, hydrolyzing II, and reducing diimides with LiAlH4. I [R3 = acyl, 4-FC6H4CO(CH2)3, 8-chloro-10,11-dihydrobenzo[b,f]thiepin-10-yl] were prepared by substitution of I (R3 = H). I [RR1 = (CH2)5, (CH2)4, R2 = Me, R3 = COCH2Ph] had analgesic activities of the same magnitude as morphine. Some other I exhibited various pharmacol. activity, but only to a degree.

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Masaret, Ghada S. published the artcileSynthesis, Docking and Antihypertensive Activity of Pyridone Derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is ChemistrySelect (2020), 5(44), 13995-14003, database is CAplus.

A substituted 4-((5-cyano-1-ethyl-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl)benzene-sulfonamides were picked up via coupling of aromatic Diazonium salt for sulfonamide derivatives on 3-cyano-6-hydroxyl-2-pyridone derivative The produced derivatives were exposed to mol. docking to predict their antihypertensive activity toward protein databank identification number (PDB ID 6JP5) complexed with an amino acids consequent from the human Voltage-dependent L-type calcium channel (LCC) alpha-1S subunit. The docking studies outcomes endorsed to utilize these analogs in vivo antihypertensive effectiveness treatise. The Mean systolic blood pressure (SBP) of hypertensive rats injected by Dihydropyridine derivatives (DHPD) were evaluated in comparable with nifedipine that utilized as standard drug. Moreover, the vasorelaxant effectiveness of the synthesized derivatives were examined against the contraction induced by noradrenaline (0.1 mM, NA) on aorta rat rings.

ChemistrySelect published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

O’Callaghan, C. N. published the artcileReaction of ethyl cyanoacetate with 2-iminochromene derivatives, Name: 2-Cyano-N-ethylacetamide, the publication is Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science (1977), 77B(19-47), 533-8, database is CAplus.

The carbamoyliminochromones I (R = H, 8-MeO, 8-EtO, 6-Cl) condensed with EtO₂CCH₂CN to give the benzopyranopyridines II. The coumarins III was also formed by a competing reaction.

Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bianchi, Maria C. published the artcileSome Aliphatic Cyanoacetylamines, SDS of cas: 15029-36-4, the publication is Atti accad. sci. Torino (1913), 654-9, database is CAplus.

5 cc. CNCH₂CO₂Et in 35 cc. Et₂O + 20 cc. absolute alc. after a passage of an excess of NH₃ gave 3 g. NCCH₂CONH₂, crystals from MeOH, m. 124-5°. 7 g. CNCH₂CO₂Et in 25 cc. Et₂O + 17 cc. absolute alc. and 25 cc. of 20% MeNH₂ gave 5 g. of cyanoacetmethylamide, CNCH₂CONHMe, m. 104-5°, decompose with KOH, neutralized with HCl its solution becomes yellow. Similarly, the ethylamide, colorless prisms from EtOH, m. 74-50. CNCH₂CO₂Et (2 mol.) + propylenediamine (1 mol.) gives dicyanoacetopropylenediamide, (CNCH₂CONH)₂C₂H₆, m. 161-2°, with KMnO₄ gives HCN and the corresponding propyleneoxamic acid. Similarly the trimethylenediamide, CH₂(CH₂NHCOCH₂CN)₂, m. 163-5°, decompose 200-10°, giving NH₃, gives a neutral H₂O solution, gives HCN and the corresponding oxamic acid with KMnO₄.

Atti accad. sci. Torino published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Al-Etaibi, Alya M. published the artcileSynthesis and antimicrobial activity of some disperse dyes derived from pyridones, Related Products of amides-buliding-blocks, the publication is International Journal of ChemTech Research (2019), 12(5), 129-133, database is CAplus.

Pyridone derivatives 4a,b are prepared by reacting N-alkyl-2-cyanoacetamide 1a,b with Me propionylacetate. Compounds 4a,b are coupled with aromatic diazonium salts to produce the corresponding new azo disperse dyes 6a,b. The antimicrobial activity of the synthesized azo disperse dyes are evaluated.

International Journal of ChemTech Research published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mu, Ruixu published the artcileDiscovery of novel triazole compounds as selective IL-1β releasement inhibitors, HPLC of Formula: 15029-36-4, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128415, database is CAplus and MEDLINE.

Inflammation and immunity are closely related to the occurrence and development of a variety of immune diseases. Although IL-1β has been identified as a key cytokine in many immune diseases, safe and specific small mol. IL-1β releasement inhibitors are still scarce and urgently required in clinic. The investigation prospect of triazoleis limited by its complicated pharmacol. effect which exhibited inferior effects on IL-1β and TNF-α. Herein, 36 novel derivatives were designed and synthesized, and nearly half of the derivatives exhibited much better selectivity on IL-1β releasement inhibition as well as keep similar inhibitory activities to lead compound In 20 μM, compound 19 exhibited IL-1β releasement inhibitory activity (IC50 = 5.489 μM) which closed to the original compound, and 4.5-fold superior selectivity (SI = 4.71) to the lead compound (SI = 0.82). A probable SAR model of triazole derivatives for IL-1β releasement inhibition and selectivity was also proposed, which might promote the discovery of more effective and specific IL-1β releasement inhibitors in the future.

Bioorganic & Medicinal Chemistry Letters published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shaik, Jeelan Basha published the artcileSynthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase, Related Products of amides-buliding-blocks, the publication is Bioorganic Chemistry (2019), 102960, database is CAplus and MEDLINE.

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a-q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate anti-oxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the Aβ aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i (I; NR₁R₂ correspond to methanamine, cyclopropamine, cyclohexamine, benzenemethanamine, and α-methylbenzenemethanamine, resp.) with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 × 10⁴, 2.22 × 10⁴, 1.18 × 10⁴, 9.8 × 10³ and 3.2 × 10⁴ M^-1 and free energy change as -5.83, -5.91, -5.51, -5.41 and -6.12 kcal M^-1 at 25 °C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with I.

Bioorganic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C7H5ClN2S, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mallikarjuna, Rangisetty published the artcileSynthesis and biological evaluation of some new 3-cyano-2-amino substituted chromene derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Pharma Chemica (2015), 7(11), 117-129, database is CAplus.

Chromenes are the one of the important class of heterocyclic compounds which poses wide range of pharmaceutical and biol. importance. Different functional groups at different positions in the core structure of chromene deliberately yields novel derivatives which play a prominent role in in the field of medicinal chem. One pot synthesis of a few new series of 2-amino-3-cyano-4H-chromene derivatives were designed, synthesized, characterized and biol. activity like anti-bacterial and anti-fungal studies were screened, where most of the compounds showed good growth inhibition activity.

Pharma Chemica published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics