Reference of 149632-73-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 149632-73-5 as follows.
Under a nitrogen atmosphere, a solution of 3,6-difluoro-9-(oxiran-2-ylmethyl)-9H-carbazole(0.7 g) andtert-butyl (1-aminopropan-2-yl)carbamate(1.5 g) in ethanol (50 mL) was stirred at 70C for 16 hrs. The mixture was concentrated under reduced pressure and purified by silica gel column chromatography, eluting with a gradient of 0-20% methanol in dichloromethane to give an off-white foam (1.28 g). The product was used directly in the next step without additional purification:1H NMR (300 MHz, CDCl3): delta 7.67 (dd, 2H,J= 8.7, 2.7 Hz), 7.42-7.37 (m, 2H), 7.22 (td, 2H,J= 9.0, 2.7 Hz), 4.55-4.30 (m, 3H), 4.13 (m, 1H), 3.78 (br s, 1H), 2.88 and 2.82 (dd, 1H,J= 12.0, 3.6 Hz), 2.70-2.50 (m, 3H), 1.45 (s, 9H), 1.13 and 1.11 (d, 3H,J= 6.6 Hz). ESI (m/z): 434.0 (M+H).
According to the analysis of related databases, 149632-73-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Humphries, Paul S.; Bersot, Ross; Kincaid, John; Mabery, Eric; McCluskie, Kerryn; Park, Timothy; Renner, Travis; Riegler, Erin; Steinfeld, Tod; Turtle, Eric D.; Wei, Zhi-Liang; Willis, Erik; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 293 – 297;,
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