Category: 148017-28-1

Adding a certain compound to certain chemical reactions, such as: 148017-28-1, name is tert-Butyl sulfamoylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 148017-28-1, Computed Properties of C5H12N2O4S

(R)-(6-chloro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl trifluoromethanesulfonate (3 g 9.0 mmol), Boc-sulfamide (1.95 g, 10 mmol), and acetone (45 mL) were placed in a 300 mL round-bottomed flask equipped with a nitrogen inlet and a magnetic stir bar. Potassium carbonate (5 g, 36 mmol) was added to the resulting mixture and stirred for 0.75 h. The progress of reaction was monitored by TLC analysis on silica gel plates using EtOAc/Heptane (1:1) as the eluent. The resulting mixture was filtered to remove the solid carbonate and the filtrate was evaporated under reduced pressure to yield (S)-tert-Butyl (6-chloro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl(sulfamoyl) carbamate as an oily residue that solidified on standing at room temperature for 24 h.1H NMR (d6-DMSO): delta7.61 (s, 2H), 6.99 (d, J=1.6 Hz, 1H), 6.94-6.86 (m, 2H), 4.49-4.39 (m, 1H), 4.25 (dd, J1=2.3, J2=11.9 Hz, 1H), 4.07 (dd, J1=5.5, J2=11.9 Hz, 1H), 3.92 (dd, J1=7.0, J2=14.9 Hz, 1H), 3.79 (dd, J1=5.5, J2=14.9 Hz, 1H), 1.40 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl sulfamoylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Abdel-Magid, Ahmed; Mehrman, Steven J.; Ferraro, Caterina; US2009/182141; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148017-28-1, name is tert-Butyl sulfamoylcarbamate, This compound has unique chemical properties. The synthetic route is as follows., category: amides-buliding-blocks

Step b: fert-Butyl (aminosulf onyl) f r(3aR,4R<6R,6aR)-6-(6-chloro-9H-purin-9-yl)- 2,2-dimethyltetrahydrofuror3,4-rfiri31dioxol-4-yl1memyl)carbamate; [0237] (2R/3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (6.352g, 0.01944mol), N-Boc-sulfamide (5.717g, 0.02913mol) and triphenylphosphine (6.119g, 0.02333mol) were dissolved in ethyl acetate (20OmL) under nitrogen and diisopropyl azodicarboxylate (5.742mL, 0.02916mol) was added dropwise. The solution was stirred for 2h, and then concentrated in vacuo. The residue was purified by flash chromatography (Hex/EtOAc 25% to 65%) to afford 5.46Og of product as a white solid and 1.4Og of product with triphenylphosphine oxide impurity. This second batch was purified by flash chromatography (Hex/EtOAc 20% to 60%). The product was obtained as a white solid (6.16Og, 63%).[0238] LCMS: R.t. 1.66 min ES+ 505 (formic acid). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 148017-28-1. Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/84281; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148017-28-1, name is tert-Butyl sulfamoylcarbamate, A new synthetic method of this compound is introduced below., 148017-28-1

Example 16 N-(4-{4-[3-(2-sulfamoylaminoethoxy)azetidin-1-yl]phenylamino}-6-methoxypyridin-3-yl)acetamide (16a) N-(4-{4-[3-(2-tert-butoxycarbonylsulfamoylaminoethoxy)azetidin-1-yl]phenylamino}-6-methoxypyridin-3-yl)acetamide N-(4-{4-[3-(2-Hydroxyethoxy)azetidin-1-yl]phenylamino}-6-methoxypyridin-3-yl)acetamide (850 mg, 2.28 mmol) produced in Example 1 (1f), N-tert-butoxycarbonylsulfamoyl amine (0.67 g, 3.4 mmol), and triphenylphosphine (0.72 g, 2.7 mmol) were suspended in ethyl acetate:tetrahydrofuran (3:1, 15 mL), diethyl azodicarboxylate (0.74 mL, 3.4 mmol) was added, and the mixture was stirred at room temperature for 20 hr. The solvent of the reaction mixture was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (chloroform:methanol, 100:0?100:4, V/V). The solvent of the object fraction was evaporated under reduced pressure to give the title object compound as a pale-yellow foam-like powder (1.05 g, yield 84%). 1H-NMR (CDCl3, 400 MHz) delta: 1.55 (9H, s), 1.96 (1H, s), 2.24 (2H, s), 3.61 (2H, t, J=5.3 Hz), 3.66-3.74 (2H, m), 3.82 (2H, s), 3.85 (1H, s), 3.98 (2H, t, J=5.3 Hz), 4.00-4.08 (2H, m), 4.38-4.46 (1H, m), 5.44-5.55 (2H, br), 6.10 (0.35H, s), 6.12 (0.35H, s), 6.15 (0.65H, s), 6.34 (0.65H, s), 6.41-6.50 (2H, m), 6.54 (0.65H, s), 6.98-7.07 (2.35H, m), 7.78 (0.65H, s), 7.79 (0.35H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kyoto Pharmaceutical Industries, Ltd.; SHIRAHASE, Hiroaki; TAKAHASHI, Kenji; SHOJI, Yoshimichi; TAKEDA, Shigemitsu; (111 pag.)US2016/207883; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics