Category: 147962-41-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147962-41-2, name is N-Propylsulfamide, This compound has unique chemical properties. The synthetic route is as follows., category: amides-buliding-blocks

A.ii. N-(5-(4-bromophenyl)-6-chloropyrimidin-4-yl)propane-1-sulfamide:tBuOK (16.0 g; 0.14 mol; 1 eq.) was added to the above prepared cold (5C) solution of Intermediate A.i in DMSO. The resulting suspension was heated to 20C and stirred for 30 mi 5-(4-bromophenyl)-4,6-dichloropyrimidine (10.7 g; 0.035 mol; 0.25 eq.) was added portionwise and the mixture was heated to 50C for 1 h. Water was added. The pH of the solution was adjusted to 4-5 using 33% aq. HC1. The suspension was cooled to 0C and stirred for 30 mm. It was filtered off, rinsed with a solution of water and MeOH and dried under reduced pressure to yield the title compound as a white solid (12.6 g, 89% yield with respect to S -(4-bromophenyl)-4,6-dichloropyrimidine).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 147962-41-2.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; ABELE, Stefan; FUNEL, Jacques-Alexis; SCHINDELHOLZ, Ivan; WO2014/155304; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

147962-41-2, name is N-Propylsulfamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C3H10N2O2S

1, 8 ml of N, N-dimethylformamide, 100 g (724 mmol) of N-propylsulfamide, 26 g (1083 mmol) of sodium hydride were added to the 1 L three-necked reaction flask, and the mixture was stirred at 10 to 15 C for 30 min, (724 mmol) of 4-bromophenyl-4,6-dichloropyrimidine was stirred at 20-25 C for 8 h and then stirred at 35-40 C for 1 h, cooled to 10-15 C,22.3 g (35.9 mmol) of ethylene glycol was added,And p-toluenesulfonyl chloride (137 g, 71.9 mmol) were added and the temperature was raised to 85-95 C. The reaction was continued for 9 h, cooled to 0-10 C. The solution was crystallized by adding 10 wt% citric acid aqueous solution. The filter cake was washed with purified water neutral,The solid was collected and dried at 40-50 C under vacuum (vacuum ? 0.08 MPa) for 8 h to give 212.5 g of crude impurities and 73.9% yield. 2, to 212.5g impurity crude addition of ethyl acetate 700ml, 75-85 C heating and stirring dissolved, hot filter, the filtrate plus methanol 3000ml crystallization, filtration, filter cake with methanol amount of washing, collecting solid,At 40-50 under reduced pressure (vacuum ? 0.08MPa) dry 8h,A mixture of 1,2-bis [[N- [5- (4-bromophenyl)] – N’-propylsulfonamide-6-oxo] pyrimidinyl] ethyl dithioate was obtained in a yield of 76.5 %.

The synthetic route of 147962-41-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hefei Jiunuo Medical Technology Co., Ltd.; Wu, Biao; Tang, Shengguo; Tan, Hongchun; (10 pag.)CN106478522; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147962-41-2, name is N-Propylsulfamide, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C3H10N2O2S

The compound of Example 1 (10 g; 20.6 mmol), propylsulfamide (3.1 g; 22.6 mmol; 1.1 eq.; prepared as described in Bolli et al, J. Med. Chem. (2012), 55, 7849-7861), TBAF.3H20 (19.5 g; 61.7 mmol; 3 eq.) and potassium carbonate (8.5 g; 61.7 mmol; 3 eq.) were suspended in DMSO (100 mL). The mixture was heated to 100C for 1 h and then cooled to 20-25C. Water (100 mL) and DCM (100 mL) were added. The org. layer was washed 3 times with water (100 mL each time), 20% aq. citric acid (100 mL) and water (100 mL) before being concentrated under reduced pressure to dryness. The residue was suspended in EA (15 mL) and heated to reflux. Hept (30 mL) was added. The mixture was allowed to cool to 20-25C on its own. The precipitate was filtered off and rinsed with Hept (10 mL). The beige solid thus collected (11.0 g) was recrystallized from EA (30 mL) and Hept (25 mL) to afford the title compound as a white solid (6.4 g; 53% yield). (0323) The product had MS and NMR data equivalent to those reported in Bolli et al, J. Med. Chem. (2012), 55, 7849-7861. LC-MS (method 1): tR = 1.89 min; 100% a/a.

According to the analysis of related databases, 147962-41-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; ABELE, Stefan; FUNEL, Jacques-Alexis; SCHINDELHOLZ, Ivan; WO2015/121397; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

147962-41-2, name is N-Propylsulfamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 147962-41-2

General procedure: Under nitrogen atmosphere, a mixture of sulfonamide 2a-h (1 mmol), maleic anhydride derivatives (2 mmol), and H6P2W18O62 catalyst (2 mmol%) in acetonitrile (2 mL), was stirred at reflux. Reaction was monitored by TLC. After achieving the reaction, dichloromethane (2 ¡Á10 mL) was added and the catalyst was filtered; water (10 mL) was then added. The organic layers were combined and dried over anhydrous sodium sulfate and removed under reduced pressure. The residue obtained was purified by flash chromatography (Merck silica gel 60H, CH2Cl2/MeOH, 9:1) to afford the corresponding sulfonyl maleimide derivatives.

Statistics shows that 147962-41-2 is playing an increasingly important role. we look forward to future research findings about N-Propylsulfamide.

Reference:
Article; Bougheloum, Chafika; Guezane Lakoud, Samia; Belghiche, Robila; Messalhi, Abdelrani; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 10; (2016); p. 1344 – 1350;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics